Strain Name:
C57BL/6J-MtgxR6161Btlr
Stock Number:
044308-MU
Citation ID:
RRID:MMRRC_044308-MU
Other Names:
R6161 (G1)
Major Collection:

Gene Information

Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Rpa1
Name: replication protein A1
Synonyms: Rpa, RP-A, 5031405K23Rik, 70kDa, RF-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 68275
Homologene: 2208
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 208440
Homologene: 40996
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: IKK1, IKKalpha, IKK-1, Chuk1, IKK[a], IKK alpha, IKK-alpha, IKK 1, IkappaB kinase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105689
Homologene: 9005
Fbxw8
Name: F-box and WD-40 domain protein 8
Synonyms: FBXO29, FBW6, FBW8, 4930438M06Rik, Fbx29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231672
Homologene: 17731
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67724
Homologene: 41000
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233789
Homologene: 56697
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: mSin3A, Sin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20466
Homologene: 32124
Mc4r
Name: melanocortin 4 receptor
Synonyms: Pkcp, Fatboy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17202
VEGA: 18
HGNC: HGNC:6932
Homologene: 4320
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, 5230400C17Rik, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18711
Homologene: 32115
Sla
Name: src-like adaptor
Synonyms: Slap-1, Slap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20491
Homologene: 36206
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p67MBP, p160MBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73732
Homologene: 141193
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, N1, Motch A, 9930111A19Rik, Mis6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70584
Homologene: 4300
Abca16
Name: ATP-binding cassette, sub-family A (ABC1), member 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233810
Homologene: 132942
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: nephrocystin 3, pcy, D330020E01Rik, 3632410F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 665700
Homologene: 90772
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, Cchl1a1, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK, ASK1, 7420452D20Rik, Mekk5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, 9430076A06Rik, LOC234973, D430038H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270120
VEGA: 9
Homologene: 82252
Zfp646
Name: zinc finger protein 646
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233905
Homologene: 8802
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20849
Homologene: 20679
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Nqo2
Name: N-ribosyldihydronicotinamide quinone reductase 2
Synonyms: Ox2, NRH: quinone oxidoreductase, Ox-2, Nmor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18105
VEGA: 13
HGNC: HGNC:7856
Homologene: 696
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 236149
Lnx2
Name: ligand of numb-protein X 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 140887
Homologene: 17737
Nebl
Name: nebulette
Synonyms: A630080F05Rik, 1200007O21Rik, Lnebl, D830029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74103
Homologene: 128431
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, C030030G16Rik, Slack
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227632
Homologene: 11055
Zfp623
Name: zinc finger protein 623
Synonyms: 2610029D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 78834
VEGA: 15
Homologene: 15994
Rpap2
Name: RNA polymerase II associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231571
Homologene: 11733
Slc24a1
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214111
VEGA: 9
Homologene: 3472
Ube2q1
Name: ubiquitin-conjugating enzyme E2Q family member 1
Synonyms: NICE-5, PRO3094, 2310012M18Rik, 1110002C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70093
Homologene: 9730
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Trh4, CerS5, Lass5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71949
Homologene: 23634
Slc39a10
Name: solute carrier family 39 (zinc transporter), member 10
Synonyms: 2900042E17Rik, Zip10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227059
Homologene: 34076
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216188
Homologene: 51942
Klhl35
Name: kelch-like 35
Synonyms: 2810406K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72184
Homologene: 27849
Atxn7l1
Name: ataxin 7-like 1
Synonyms: Atxn7l4, 2810423G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 380753
Homologene: 53366
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192950
Homologene: 135717
Masp2
Name: mannan-binding lectin serine peptidase 2
Synonyms: MASP-2, MAp19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Ccl7
Name: chemokine (C-C motif) ligand 7
Synonyms: mcp3, marc, MCP-3, Scya7, fic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20306
Homologene: 133974
Stard4
Name: StAR-related lipid transfer (START) domain containing 4
Synonyms: 4632419C16Rik, 9030213J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 170459
Homologene: 15874
Wnt8a
Name: wingless-type MMTV integration site family, member 8A
Synonyms: Stra11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20890
VEGA: 18
Homologene: 7553
Cd3eap
Name: CD3E antigen, epsilon polypeptide associated protein
Synonyms: PAF49, 2610103M17Rik, Ase1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70333
Homologene: 17107
Sra1
Name: steroid receptor RNA activator 1
Synonyms: Srap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 24068
Homologene: 11906
Hao1
Name: hydroxyacid oxidase 1, liver
Synonyms: Hao-1, Gox1, GOX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15112
HGNC: HGNC:4809
Homologene: 6578
Syt1
Name: synaptotagmin I
Synonyms: G630098F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 20979
Homologene: 4122
Vmn1r159
Name: vomeronasal 1 receptor 159
Synonyms: Gm16507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 670857
Homologene: 104166
Pbx2
Name: pre B cell leukemia homeobox 2
Synonyms: G17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18515
HGNC: HGNC:8633
Homologene: 48115
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,167,352 bp
  • G to A, chromosome 1 at 46,827,407 bp
  • A to T, chromosome 1 at 52,074,677 bp
  • A to G, chromosome 1 at 65,216,043 bp
  • A to G, chromosome 2 at 17,730,830 bp
  • A to G, chromosome 2 at 25,903,385 bp
  • A to T, chromosome 2 at 26,468,731 bp
  • A to G, chromosome 2 at 31,356,254 bp
  • A to C, chromosome 2 at 82,987,257 bp
  • A to T, chromosome 2 at 125,369,801 bp
  • A to T, chromosome 2 at 134,505,625 bp
  • T to A, chromosome 3 at 89,781,360 bp
  • A to G, chromosome 4 at 148,041,754 bp
  • A to T, chromosome 4 at 148,614,012 bp
  • A to G, chromosome 5 at 107,620,670 bp
  • T to C, chromosome 5 at 118,092,675 bp
  • C to T, chromosome 5 at 147,042,026 bp
  • T to C, chromosome 6 at 119,057,302 bp
  • G to A, chromosome 7 at 19,357,633 bp
  • C to T, chromosome 7 at 22,843,187 bp
  • A to G, chromosome 7 at 28,565,267 bp
  • A to G, chromosome 7 at 99,473,337 bp
  • A to T, chromosome 7 at 118,163,330 bp
  • A to T, chromosome 7 at 120,540,711 bp
  • C to T, chromosome 7 at 127,878,725 bp
  • A to G, chromosome 9 at 16,377,522 bp
  • A to G, chromosome 9 at 18,647,818 bp
  • T to C, chromosome 9 at 57,095,424 bp
  • T to C, chromosome 9 at 64,937,263 bp
  • A to G, chromosome 9 at 95,865,319 bp
  • A to G, chromosome 9 at 104,031,906 bp
  • T to C, chromosome 10 at 20,000,575 bp
  • C to T, chromosome 10 at 83,520,338 bp
  • A to G, chromosome 10 at 108,631,807 bp
  • G to A, chromosome 11 at 6,600,902 bp
  • G to T, chromosome 11 at 72,446,012 bp
  • A to G, chromosome 11 at 75,314,895 bp
  • T to C, chromosome 11 at 82,046,586 bp
  • T to A, chromosome 12 at 33,358,663 bp
  • T to C, chromosome 13 at 9,647,007 bp
  • A to T, chromosome 13 at 24,971,414 bp
  • G to A, chromosome 13 at 33,979,651 bp
  • A to T, chromosome 14 at 103,298,747 bp
  • T to C, chromosome 15 at 34,526,310 bp
  • T to C, chromosome 15 at 66,782,598 bp
  • T to A, chromosome 15 at 75,948,621 bp
  • A to G, chromosome 15 at 99,738,663 bp
  • A to G, chromosome 17 at 34,593,600 bp
  • A to G, chromosome 18 at 33,209,056 bp
  • T to C, chromosome 18 at 34,545,546 bp
  • G to A, chromosome 18 at 36,670,283 bp
  • A to T, chromosome 18 at 66,859,180 bp
  • A to T, chromosome 19 at 7,786,447 bp
  • T to C, chromosome 19 at 44,082,637 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6161 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044308-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.