Strain Name:
C57BL/6J-MtgxR6250Btlr
Stock Number:
044367-MU
Citation ID:
RRID:MMRRC_044367-MU
Other Names:
R6250 (G1)
Major Collection:

Gene Information

Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
Synonyms: 2410004D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71978
VEGA: 14
HGNC: HGNC:9304
Homologene: 2035
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: p110beta, 1110001J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Ythdf1
Name: YTH N6-methyladenosine RNA binding protein 1
Synonyms: 2210410K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228994
Homologene: 9844
Commd10
Name: COMM domain containing 10
Synonyms: 2310003A05Rik, DRWMS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69456
VEGA: 18
Homologene: 9404
Kif1b
Name: kinesin family member 1B
Synonyms: A530096N05Rik, Kif1b alpha, Kif1b beta, D4Mil1e, KIF1Bp204, N-3 kinesin, KIF1Bp130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16561
Homologene: 99835
Epb41
Name: erythrocyte membrane protein band 4.1
Synonyms: Elp-1, Elp1, D4Ertd442e, 4.1R, Epb4.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269587
HGNC: HGNC:3377
Homologene: 44324
Ranbp3
Name: RAN binding protein 3
Synonyms: 2610024N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71810
VEGA: 17
HGNC: HGNC:9850
Homologene: 136516
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, D11Bwg0410e, Prp8, Sfprp8l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192159
Homologene: 4706
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: Gtl7, 6530416A09Rik, 2900005O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76246
Homologene: 133868
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Ipo13
Name: importin 13
Synonyms: Imp13, Kap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230673
Homologene: 40968
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Krt25
Name: keratin 25
Synonyms: mIRSa1, 4631426H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70810
Homologene: 77127
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 80913
Homologene: 69183
Rcor1
Name: REST corepressor 1
Synonyms: Rocr1, 6720480E22Rik, D12Wsu95e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217864
Homologene: 32246
Ccnd3
Name: cyclin D3
Synonyms: 9230106B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12445
HGNC: HGNC:1585
Homologene: 20419
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233904
Homologene: 52251
Lman1l
Name: lectin, mannose-binding 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235416
HGNC: HGNC:6632
Homologene: 11047
Mxra8
Name: matrix-remodelling associated 8
Synonyms: 1200013A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74761
HGNC: HGNC:7542
Homologene: 11500
Sdc4
Name: syndecan 4
Synonyms: syndecan-4, S4, Synd4, ryudocan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20971
Homologene: 31121
Rnf44
Name: ring finger protein 44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105239
Homologene: 8934
Hrob
Name: homologous recombination factor with OB-fold
Synonyms: BC030867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217216
Homologene: 69368
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ap3s1
Name: adaptor-related protein complex 3, sigma 1 subunit
Synonyms: [s]3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 11777
VEGA: 18
HGNC: HGNC:2013
Homologene: 4254
Cnbd1
Name: cyclic nucleotide binding domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435772
Homologene: 27843
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70853
Homologene: 27053
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, 6330504P12Rik, LTRPC3, melastatin 2, B930001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 637515
Homologene: 19080
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, MIBP1, Schnurri-2, Shn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Fbxo24
Name: F-box protein 24
Synonyms: 4933422D21Rik, Fbx24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71176
Homologene: 14131
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Pak5
Name: p21 (RAC1) activated kinase 5
Synonyms: Pak5, Pak7, 2900083L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241656
Homologene: 22211
Gucy2g
Name: guanylate cyclase 2g
Synonyms: GC-G, 2410077I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73707
Homologene: 44544
Ak9
Name: adenylate kinase 9
Synonyms: Akd1, Gm7127, Akd2, LOC215946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 633979
Homologene: 67934
Eps8l3
Name: EPS8-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99662
Homologene: 15878
Disp2
Name: dispatched RND tramsporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214240
Homologene: 24916
Olfr191
Name: olfactory receptor 191
Synonyms: MOR183-5P, GA_x54KRFPKG5P-55314632-55313703
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258035
Homologene: 128162
Olfr155
Name: olfactory receptor 155
Synonyms: OR37A, Olfr37a, MOR262-14, GA_x6K02T2N78B-16092200-16091241, mOR37a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29845
HGNC: HGNC:8276
Homologene: 84331
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 52372
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235527
Homologene: 23217
Zfp709
Name: zinc finger protein 709
Synonyms: GIOT-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 236193
Homologene: 136795
Jchain
Name: immunoglobulin joining chain
Synonyms: J chain, Jch, Igj, 9530090F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16069
HGNC: HGNC:5713
Homologene: 16958
Abhd12
Name: abhydrolase domain containing 12
Synonyms: 6330583M11Rik, 1500011G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76192
Homologene: 22910
Slc30a8
Name: solute carrier family 30 (zinc transporter), member 8
Synonyms: ZnT8, ZnT-8, C820002P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239436
Homologene: 13795
Olfr1381
Name: olfactory receptor 1381
Synonyms: MOR256-26, GA_x6K02T2QP88-5884501-5883566
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258461
Homologene: 72463
Rcor3
Name: REST corepressor 3
Synonyms: E130101E15Rik, 4921514E24Rik, C730034D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214742
Homologene: 135671
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Snx22
Name: sorting nexin 22
Synonyms: LOC382083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382083
VEGA: 9
Homologene: 11723
Vps9d1
Name: VPS9 domain containing 1
Synonyms: 2410004N05Rik, 1300018I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72325
Homologene: 21021
Faim
Name: Fas apoptotic inhibitory molecule
Synonyms: Faim-L, Faim-S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23873
Homologene: 8018
Rassf7
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Synonyms: 2400009B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66985
HGNC: HGNC:1166
Homologene: 2595
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240427
Homologene: 9192
Mfsd4b1
Name: major facilitator superfamily domain containing 4B1
Synonyms: AI317395
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215929
Homologene: 77426
Eef1a2
Name: eukaryotic translation elongation factor 1 alpha 2
Synonyms: S1, Eef1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13628
HGNC: HGNC:3192
Homologene: 121568
Glrx
Name: glutaredoxin
Synonyms: TTase, Grx1, D13Wsu156e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 93692
HGNC: HGNC:4330
Homologene: 37566
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: Fam75d3, 1700013B16Rik, Fam75d1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
B430218F22Rik
Name: RIKEN cDNA B430218F22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Sprr4
Name: small proline-rich protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,051,885 bp
  • T to A, chromosome 1 at 44,164,049 bp
  • G to T, chromosome 1 at 192,100,896 bp
  • A to T, chromosome 2 at 118,790,766 bp
  • T to C, chromosome 2 at 119,675,177 bp
  • T to C, chromosome 2 at 136,174,269 bp
  • T to C, chromosome 2 at 150,839,747 bp
  • A to T, chromosome 2 at 164,431,218 bp
  • T to C, chromosome 2 at 180,911,100 bp
  • A to G, chromosome 2 at 181,151,060 bp
  • G to T, chromosome 3 at 92,500,463 bp
  • A to T, chromosome 3 at 107,890,465 bp
  • T to A, chromosome 4 at 19,098,255 bp
  • T to C, chromosome 4 at 43,854,363 bp
  • A to G, chromosome 4 at 76,128,995 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • A to G, chromosome 4 at 117,912,154 bp
  • A to T, chromosome 4 at 131,989,873 bp
  • A to G, chromosome 4 at 149,213,643 bp
  • G to T, chromosome 4 at 155,841,089 bp
  • T to C, chromosome 5 at 88,526,175 bp
  • A to G, chromosome 5 at 121,339,498 bp
  • A to G, chromosome 5 at 137,621,281 bp
  • G to A, chromosome 6 at 87,111,212 bp
  • G to A, chromosome 7 at 28,150,714 bp
  • A to G, chromosome 7 at 127,791,299 bp
  • A to G, chromosome 7 at 141,217,243 bp
  • TCGACG to TCG, chromosome 8 at 71,890,708 bp
  • T to C, chromosome 8 at 123,248,208 bp
  • A to G, chromosome 9 at 57,615,624 bp
  • C to A, chromosome 9 at 66,069,641 bp
  • G to A, chromosome 9 at 92,484,828 bp
  • A to T, chromosome 9 at 98,992,123 bp
  • A to C, chromosome 9 at 99,094,598 bp
  • T to C, chromosome 10 at 14,131,759 bp
  • T to C, chromosome 10 at 40,003,110 bp
  • T to C, chromosome 10 at 41,389,034 bp
  • T to C, chromosome 10 at 80,325,592 bp
  • A to T, chromosome 11 at 49,551,884 bp
  • A to T, chromosome 11 at 71,181,799 bp
  • T to G, chromosome 11 at 75,493,508 bp
  • T to A, chromosome 11 at 99,321,163 bp
  • A to G, chromosome 11 at 102,255,062 bp
  • T to C, chromosome 12 at 8,744,755 bp
  • G to T, chromosome 12 at 111,111,877 bp
  • A to T, chromosome 13 at 54,682,107 bp
  • A to G, chromosome 13 at 59,701,801 bp
  • A to T, chromosome 13 at 75,840,110 bp
  • A to G, chromosome 13 at 118,387,408 bp
  • A to T, chromosome 14 at 67,038,954 bp
  • G to A, chromosome 15 at 52,335,149 bp
  • G to A, chromosome 16 at 59,085,832 bp
  • T to A, chromosome 17 at 47,597,562 bp
  • T to G, chromosome 17 at 56,677,208 bp
  • T to C, chromosome 18 at 46,754,447 bp
  • A to G, chromosome 18 at 46,963,688 bp
  • T to C, chromosome 18 at 78,858,002 bp
  • T to C, chromosome 18 at 80,756,521 bp
  • A to G, chromosome 19 at 22,910,054 bp
  • A to T, chromosome 19 at 55,217,424 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6250 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044367-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.