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Strain Name:
C57BL/6J-MtgxR6271Btlr/Mmmh
Stock Number:
044379-MU
Citation ID:
RRID:MMRRC_044379-MU
Other Names:
R6271 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, elf3, elf1, spectrin G, brain spectrin, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Serinc3
Name: serine incorporator 3
Synonyms: TMS-1, DIFF33, AIGP1, Tde1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26943
Homologene: 38230
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72103
Homologene: 49753
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Cisd2
Name: CDGSH iron sulfur domain 2
Synonyms: 1500031D15Rik, 1500026J14Rik, B630006A20Rik, 1500009M05Rik, Miner1, Zcd2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67006
Homologene: 36436
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C130057E09Rik, C030046E11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226089
Homologene: 13806
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Hyls1
Name: HYLS1, centriolar and ciliogenesis associated
Synonyms: 3010015K02Rik, hydrolethalus syndrome 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76832
Homologene: 82283
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Lhfpl3
Name: lipoma HMGIC fusion partner-like 3
Synonyms: A930031L14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269629
HGNC: HGNC:6589
Homologene: 26732
Babam2
Name: BRISC and BRCA1 A complex member 2
Synonyms: 6030405P19Rik, B830038C02Rik, Bre
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107976
HGNC: HGNC:1106
Homologene: 3604
Nop9
Name: NOP9 nucleolar protein
Synonyms: 2610027L16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67842
Homologene: 41678
Ldah
Name: lipid droplet associated hydrolase
Synonyms: 1110057K04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68832
VEGA: 12
Homologene: 41453
Prmt9
Name: protein arginine methyltransferase 9
Synonyms: Prmt10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102182
Homologene: 16298
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Piezo1, Fam38a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Tmprss3
Name: transmembrane protease, serine 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 140765
Homologene: 56985
B3gat2
Name: beta-1,3-glucuronyltransferase 2
Synonyms: GlcAT-S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 280645
HGNC: HGNC:922
Homologene: 50574
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, cHKA, Atp1al1, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Fer1l6
Name: fer-1 like family member 6
Synonyms: EG631797
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 631797
Homologene: 53396
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 333669
Homologene: 129891
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Ces2c
Name: carboxylesterase 2C
Synonyms: Ces2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234671
HGNC: HGNC:1864
Homologene: 138298
Parp10
Name: poly (ADP-ribose) polymerase family, member 10
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 671535
Homologene: 53133
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Or12k5
Name: olfactory receptor family 12 subfamily K member 5
Synonyms: GA_x6K02T2NLDC-33697309-33696317, MOR159-4, Olfr358
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227789
Homologene: 74157
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 408191
Homologene: 130042
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319719
Homologene: 131217
Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Synonyms: p450c17, Cyp17, steroid 17-alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13074
HGNC: HGNC:2593
Homologene: 73875
Fam234a
Name: family with sequence similarity 234, member A
Synonyms: Itfg3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106581
Homologene: 12932
Ltv1
Name: LTV1 ribosome biogenesis factor
Synonyms: 2610020N02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353258
VEGA: 10
Homologene: 6338
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Gm7196, Vmn2r-ps113
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 637021
Homologene: 115024
Or7g31
Name: olfactory receptor family 7 subfamily G member 31
Synonyms: GA_x6K02T2PVTD-13214162-13213224, MOR147-2, Olfr850
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258516
HGNC: HGNC:8466
Homologene: 121552
Kcna3
Name: potassium voltage-gated channel, shaker-related subfamily, member 3
Synonyms: Kv1.3, Kca1-3, Mk-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16491
HGNC: HGNC:6221
Homologene: 128570
Krt36
Name: keratin 36
Synonyms: HRa-1, Krt1-22, keratin 5, Krt1-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16673
HGNC: HGNC:6454
Homologene: 88459
Slc66a3
Name: solute carrier family 66 member 3
Synonyms: E030024M05Rik, Pqlc3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217430
Homologene: 16454
Or8c9
Name: olfactory receptor family 8 subfamily C member 9
Synonyms: MTPCR18, MOR170-4, GA_x6K02T2PVTD-32017922-32018863, Olfr25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18323
VEGA: 9
Oxct2b
Name: 3-oxoacid CoA transferase 2B
Synonyms: Scot-t2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 353371
Homologene: 137359
Or4c12b
Name: olfactory receptor family 4 subfamily C member 12B
Synonyms: GA_x6K02T2Q125-51257221-51258135, MOR232-4, Olfr1255
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258979
Homologene: 82298
Smyd2
Name: SET and MYND domain containing 2
Synonyms: Zmynd14, 1110020E07Rik, KMT3C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226830
Homologene: 32466
Mkx
Name: mohawk homeobox
Synonyms: 9430023B20Rik, Irxl1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 210719
Homologene: 72239
Preb
Name: prolactin regulatory element binding
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50907
HGNC: HGNC:9356
Homologene: 40877
Fv1
Name: Friend virus susceptibility 1
Synonyms: Rv-1, Fv-1, Rv1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14349
Ubiad1
Name: UbiA prenyltransferase domain containing 1
Synonyms: Tere1, 1200002M06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71707
Homologene: 8336
Pcdhga5
Name: protocadherin gamma subfamily A, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93713
HGNC: HGNC:8703
Homologene: 69263
Trav6-4
Name: T cell receptor alpha variable 6-4
Synonyms: Gm13945
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126463
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 23,815,261 bp
  • T to A, chromosome 1 at 32,545,491 bp
  • A to G, chromosome 1 at 189,883,852 bp
  • T to C, chromosome 2 at 37,005,542 bp
  • T to C, chromosome 2 at 89,816,562 bp
  • G to C, chromosome 2 at 163,630,976 bp
  • T to A, chromosome 3 at 107,037,606 bp
  • T to C, chromosome 3 at 135,408,866 bp
  • T to C, chromosome 4 at 49,792,516 bp
  • A to C, chromosome 4 at 88,643,845 bp
  • A to C, chromosome 4 at 118,595,759 bp
  • T to G, chromosome 4 at 123,117,715 bp
  • G to T, chromosome 4 at 133,064,724 bp
  • A to G, chromosome 4 at 147,870,017 bp
  • A to T, chromosome 4 at 148,436,626 bp
  • G to T, chromosome 5 at 22,746,244 bp
  • C to A, chromosome 5 at 30,958,051 bp
  • G to T, chromosome 5 at 32,001,362 bp
  • A to C, chromosome 5 at 108,174,887 bp
  • T to C, chromosome 6 at 4,730,015 bp
  • T to C, chromosome 6 at 87,646,248 bp
  • C to A, chromosome 7 at 46,252,040 bp
  • A to G, chromosome 7 at 66,307,103 bp
  • A to G, chromosome 7 at 112,087,056 bp
  • A to G, chromosome 8 at 77,577,463 bp
  • G to A, chromosome 8 at 104,852,116 bp
  • G to T, chromosome 8 at 122,494,932 bp
  • A to G, chromosome 9 at 19,478,041 bp
  • G to A, chromosome 9 at 35,561,184 bp
  • T to C, chromosome 9 at 38,330,282 bp
  • T to C, chromosome 10 at 5,234,652 bp
  • T to C, chromosome 10 at 13,179,701 bp
  • T to C, chromosome 10 at 27,023,329 bp
  • T to A, chromosome 10 at 75,995,809 bp
  • T to C, chromosome 10 at 128,250,724 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • G to T, chromosome 11 at 30,100,660 bp
  • A to T, chromosome 11 at 77,573,783 bp
  • A to G, chromosome 11 at 77,820,809 bp
  • G to A, chromosome 11 at 100,104,472 bp
  • G to A, chromosome 12 at 8,268,599 bp
  • T to C, chromosome 12 at 16,997,703 bp
  • C to A, chromosome 12 at 75,890,381 bp
  • C to T, chromosome 13 at 3,581,891 bp
  • G to T, chromosome 13 at 13,658,754 bp
  • T to G, chromosome 13 at 54,539,724 bp
  • A to G, chromosome 13 at 73,266,594 bp
  • A to T, chromosome 14 at 23,509,889 bp
  • A to T, chromosome 14 at 53,454,582 bp
  • A to C, chromosome 14 at 55,753,741 bp
  • A to G, chromosome 14 at 56,378,422 bp
  • T to A, chromosome 15 at 58,641,918 bp
  • T to C, chromosome 15 at 76,242,002 bp
  • A to T, chromosome 16 at 23,003,948 bp
  • A to G, chromosome 17 at 18,062,883 bp
  • T to C, chromosome 17 at 26,218,237 bp
  • G to A, chromosome 17 at 28,881,368 bp
  • T to C, chromosome 17 at 31,186,562 bp
  • A to T, chromosome 18 at 6,937,059 bp
  • T to C, chromosome 18 at 37,696,682 bp
  • A to T, chromosome 19 at 29,567,365 bp
  • A to G, chromosome 19 at 46,672,720 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6271 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044379-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.