Strain Name:
C57BL/6J-MtgxR6559Btlr/Mmmh
Stock Number:
044683-MU
Citation ID:
RRID:MMRRC_044683-MU
Other Names:
R6559 (G1)
Major Collection:

Strain Information

Actn4
Name: actinin alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Fcrl1
Name: Fc receptor-like 1
Synonyms: A230020G22Rik, Fcrh1, BXMAS1-like, mBXMH1, IFGP1, moFcRH1S, mIFGP1, moFcRH1, moFcRH1L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229499
Homologene: 50472
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, Grip1, TIF2/GRIP-1, D1Ertd433e, KAT13C, glucocorticoid receptor-interacting protein 1, bHLHe75, TIF2, TIF-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: Fv-2, Fv2, STK, CDw136, PTK8, friend virus susceptibility 2, Ron
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Cdkl3
Name: cyclin dependent kinase like 3
Synonyms: B230379H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213084
Homologene: 49467
Tnfaip3
Name: tumor necrosis factor, alpha-induced protein 3
Synonyms: zinc finger protein A20, Tnfip3, A20
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21929
Homologene: 4582
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: Armc4, 4930463I21Rik, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Myo1c
Name: myosin IC
Synonyms: mm1beta, C80397, myr2, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Teddm1a
Name: transmembrane epididymal protein 1A
Synonyms: Epdd1, Teddm1, e9-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240819
Homologene: 82370
Or8c10
Name: olfactory receptor family 8 subfamily C member 10
Synonyms: MOR170-14, MOR170-8, GA_x6K02T2PVTD-32060891-32061865, Olfr899, Olfr250, GA_x6K02T2MYUG-19447-18473
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404312
VEGA: 9
Homologene: 74151
4930522H14Rik
Name: RIKEN cDNA 4930522H14 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67646
Homologene: 49856
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Or6c215
Name: olfactory receptor family 6 subfamily C member 215
Synonyms: Olfr811, MOR110-6, GA_x6K02T2PULF-11481207-11480248
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258545
Homologene: 133725
Klhl3
Name: kelch-like 3
Synonyms: EG627648, 7530408C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Lipi
Name: lipase, member I
Synonyms: lpd1, D930038D03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320355
Homologene: 77864
Ifit3
Name: interferon-induced protein with tetratricopeptide repeats 3
Synonyms: Ifi49
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15959
HGNC: HGNC:5411
Homologene: 1189
Zscan4-ps3
Name: zinc finger and SCAN domain containing 4, pseudogene 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043042
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 13,150,617 bp
  • A to T, chromosome 1 at 153,892,365 bp
  • A to G, chromosome 3 at 87,391,253 bp
  • C to T, chromosome 4 at 109,505,805 bp
  • T to C, chromosome 6 at 134,513,254 bp
  • A to G, chromosome 7 at 11,610,412 bp
  • C to T, chromosome 7 at 24,126,463 bp
  • T to C, chromosome 7 at 28,907,036 bp
  • G to C, chromosome 8 at 40,796,292 bp
  • A to G, chromosome 9 at 7,139,501 bp
  • A to G, chromosome 9 at 38,367,756 bp
  • A to G, chromosome 9 at 107,908,271 bp
  • A to G, chromosome 10 at 19,007,248 bp
  • A to T, chromosome 10 at 129,801,664 bp
  • A to G, chromosome 11 at 52,025,869 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • G to A, chromosome 11 at 116,155,446 bp
  • G to A, chromosome 13 at 58,016,476 bp
  • A to G, chromosome 15 at 99,944,475 bp
  • A to G, chromosome 16 at 75,541,094 bp
  • T to C, chromosome 16 at 94,422,349 bp
  • T to C, chromosome 18 at 7,223,664 bp
  • T to C, chromosome 19 at 34,587,114 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6559 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044683-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.