Strain Name:
C57BL/6J-MtgxR6678Btlr/Mmmh
Stock Number:
044797-MU
Citation ID:
RRID:MMRRC_044797-MU
Other Names:
R6678 (G1)
Major Collection:

Strain Information

Sf1
Name: splicing factor 1
Synonyms: WBP4, MZFM, Zfp162, CW17R
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22668
Homologene: 134065
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: GAT-1, Gabt1, Gabt, Xtrp1, XT-1, Gat1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232333
Homologene: 2290
Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: KShIIIB, C230009H10Rik, KV4, Kcr2-1, Kv3.1, NGK2, Shaw
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: HSP110, hsp-E7I, hsp110/105, Hsp105
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15505
Homologene: 21322
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Ndel1
Name: nudE neurodevelopment protein 1 like 1
Synonyms: 2600006O07Rik, mNudel
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83431
Homologene: 32567
Rreb1
Name: ras responsive element binding protein 1
Synonyms: sao, B930013M22Rik, 1110037N09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Golga2
Name: golgin A2
Synonyms: GM130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99412
HGNC: HGNC:4425
Homologene: 3300
P2rx6
Name: purinergic receptor P2X, ligand-gated ion channel, 6
Synonyms: P2xm, P2rxl1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18440
HGNC: HGNC:8538
Homologene: 3975
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, CD91, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: 4921531P07Rik, Dnahc12, DHC3, HL19, DLP12, HL-19, Hdhc3, Dnahc7l, LOC380889
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: G7c, D17H6S56E-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27762
Homologene: 11895
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9430004C13Rik, 9630046L06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Wdpcp
Name: WD repeat containing planar cell polarity effector
Synonyms: AV249152, homoloc-13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216560
Homologene: 9299
Ttc22
Name: tetratricopeptide repeat domain 22
Synonyms: 4732467L16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230576
Homologene: 89253
Gramd4
Name: GRAM domain containing 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223752
Homologene: 18199
Plcl1
Name: phospholipase C-like 1
Synonyms: PLC-L, C230017K02Rik, PRIP-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Or5al1
Name: olfactory receptor family 5 subfamily AL member 1
Synonyms: GA_x6K02T2Q125-47629317-47628376, MOR185-10, Olfr1042
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257941
Homologene: 133665
Zyg11a
Name: zyg-11 family member A, cell cycle regulator
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230590
Homologene: 66294
Gdap1l1
Name: ganglioside-induced differentiation-associated protein 1-like 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228858
HGNC: HGNC:4213
Homologene: 11426
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 2610014F08Rik, 1700048E19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19731
Homologene: 9039
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Vmn1r113
Name: vomeronasal 1 receptor 113
Synonyms: Gm5748
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436135
Homologene: 104166
Spata31e4
Name: spermatogenesis associated 31 subfamily E member 4
Synonyms: Gm8765
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 667693
Homologene: 134512
Ms4a13
Name: membrane-spanning 4-domains, subfamily A, member 13
Synonyms: 1700060E18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73466
Homologene: 77851
Dap
Name: death-associated protein
Synonyms: 4921531N22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223453
HGNC: HGNC:2672
Homologene: 3235
Prelp
Name: proline arginine-rich end leucine-rich repeat
Synonyms: SLRR2A, 7330409J17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116847
HGNC: HGNC:9357
Homologene: 2041
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78749
Homologene: 37121
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Klhl41
Name: kelch-like 41
Synonyms: Kbtbd10, LOC228003
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228003
Homologene: 4421
Gm43302
Name: predicted gene 43302
Type: Gene
Species: Mouse
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,460,810 bp
  • A to G, chromosome 1 at 55,695,776 bp
  • C to T, chromosome 1 at 133,914,775 bp
  • T to C, chromosome 1 at 152,524,724 bp
  • T to C, chromosome 2 at 32,299,060 bp
  • G to A, chromosome 2 at 59,862,631 bp
  • T to G, chromosome 2 at 69,670,844 bp
  • A to T, chromosome 2 at 86,160,185 bp
  • T to A, chromosome 2 at 163,438,654 bp
  • C to A, chromosome 3 at 116,753,320 bp
  • T to A, chromosome 4 at 106,623,045 bp
  • A to G, chromosome 4 at 108,189,681 bp
  • A to G, chromosome 5 at 23,499,295 bp
  • G to T, chromosome 5 at 105,290,954 bp
  • A to C, chromosome 5 at 149,618,497 bp
  • A to G, chromosome 6 at 114,307,776 bp
  • G to A, chromosome 7 at 20,787,978 bp
  • A to G, chromosome 7 at 46,397,805 bp
  • A to G, chromosome 7 at 101,832,270 bp
  • A to C, chromosome 8 at 25,833,777 bp
  • T to A, chromosome 10 at 11,166,545 bp
  • G to A, chromosome 10 at 127,560,136 bp
  • A to G, chromosome 11 at 21,721,105 bp
  • T to C, chromosome 11 at 68,833,413 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • G to T, chromosome 13 at 37,899,699 bp
  • A to G, chromosome 13 at 50,701,910 bp
  • G to A, chromosome 14 at 26,735,692 bp
  • C to T, chromosome 15 at 31,273,250 bp
  • T to C, chromosome 15 at 78,908,514 bp
  • A to T, chromosome 15 at 86,091,503 bp
  • G to C, chromosome 15 at 86,091,504 bp
  • C to A, chromosome 16 at 17,570,956 bp
  • T to C, chromosome 16 at 57,569,970 bp
  • G to A, chromosome 17 at 33,575,845 bp
  • C to A, chromosome 17 at 35,019,800 bp
  • C to T, chromosome 18 at 37,731,202 bp
  • T to A, chromosome 19 at 6,374,513 bp
  • T to C, chromosome 19 at 11,183,858 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6678 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044797-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.