Strain Name:
C57BL/6J-MtgxR6837Btlr/Mmmh
Stock Number:
044945-MU
Citation ID:
RRID:MMRRC_044945-MU
Other Names:
R6837 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269132
Homologene: 22865
Npy5r
Name: neuropeptide Y receptor Y5
Synonyms: Y5R
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18168
HGNC: HGNC:7958
Homologene: 21241
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Stx16
Name: syntaxin 16
Synonyms: 5430410K23Rik, SYN16, 6330500A18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228960
Homologene: 2791
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, D15F32S1h, D7H15F32S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Yars1
Name: tyrosyl-tRNA synthetase 1
Synonyms: Yars
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107271
Homologene: 2730
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: Rbbp1, A630067N03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Fas
Name: Fas cell surface death receptor
Synonyms: Tnfrsf6, APO-1, CD95, TNFR6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14102
VEGA: 19
Homologene: 27
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Sla
Name: src-like adaptor
Synonyms: Slap, Slap-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20491
Homologene: 36206
Prune2
Name: prune homolog 2
Synonyms: Olfaxin, A330102H22Rik, A230083H22Rik, 6330414G02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, Mtap2, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Mtnap1
Name: mitochondrial nucleoid associated protein 1
Synonyms: D11Wsu47e, Gm57859
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276852
Homologene: 9928
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: TRPP2, PC2, C030034P18Rik, polycystin-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Dpysl3
Name: dihydropyrimidinase-like 3
Synonyms: Ulip1, 9430041P20Rik, Ulip, CRMP4, TUC4, CRMP-4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22240
HGNC: HGNC:3015
Homologene: 20361
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5/6A, PC6, b2b1549Clo, SPC6, PC5A, b2b585Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Gm10267
Name: predicted gene 10267
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100042855
Homologene: 104911
Rasal3
Name: RAS protein activator like 3
Synonyms: A430107D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320484
Homologene: 18901
Ntsr2
Name: neurotensin receptor 2
Synonyms: NTRL, NT2R
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18217
VEGA: 12
HGNC: HGNC:8040
Homologene: 7452
Anxa8
Name: annexin A8
Synonyms: Anx8
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11752
Homologene: 20393
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 666002
Homologene: 86604
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: Kv3.2, KShIIIA
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Tmf1
Name: TATA element modulatory factor 1
Synonyms: 7030402D04Rik, LOC232286
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232286
Homologene: 133801
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244962
Homologene: 17823
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29816
Homologene: 78348
Slc5a4b
Name: solute carrier family 5 (neutral amino acid transporters, system A), member 4b
Synonyms: SAAT1, pSGLT2, SGLT3b, 2010104G07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64454
Homologene: 56968
Hhla1
Name: HERV-H LTR-associating 1
Synonyms: F930104E18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 654498
HGNC: HGNC:4904
Homologene: 129987
Hdac9
Name: histone deacetylase 9
Synonyms: Hdac7b, Mitr, D030072B18Rik, HDRP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 79221
Homologene: 128578
Hcfc2
Name: host cell factor C2
Synonyms: 1700129L13Rik, fkls
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67933
Homologene: 8337
Maip1
Name: matrix AAA peptidase interacting protein 1
Synonyms: 9430016H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68115
Homologene: 11565
Tuba4a
Name: tubulin, alpha 4A
Synonyms: M[a]4, Tuba4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22145
Homologene: 68496
Pex13
Name: peroxisomal biogenesis factor 13
Synonyms: 2610008O20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72129
HGNC: HGNC:8855
Homologene: 1967
Aup1
Name: ancient ubiquitous protein 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11993
HGNC: HGNC:891
Homologene: 7239
Or51f1d
Name: olfactory receptor family 51 subfamily F member 1D
Synonyms: Olfr583, MOR14-6, GA_x6K02T2PBJ9-5762668-5763618
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258752
Homologene: 133721
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 57,415,732 bp
  • T to C, chromosome 1 at 66,414,572 bp
  • T to C, chromosome 1 at 75,217,394 bp
  • C to T, chromosome 1 at 152,506,828 bp
  • G to A, chromosome 2 at 174,094,002 bp
  • A to G, chromosome 3 at 98,070,854 bp
  • T to A, chromosome 4 at 129,209,751 bp
  • A to T, chromosome 5 at 96,726,973 bp
  • T to G, chromosome 5 at 104,477,043 bp
  • A to G, chromosome 5 at 123,998,865 bp
  • C to T, chromosome 6 at 83,057,298 bp
  • G to A, chromosome 6 at 97,176,581 bp
  • T to G, chromosome 7 at 56,189,841 bp
  • G to C, chromosome 7 at 100,448,746 bp
  • T to A, chromosome 7 at 103,051,722 bp
  • T to A, chromosome 8 at 66,681,740 bp
  • C to T, chromosome 9 at 67,910,222 bp
  • C to T, chromosome 9 at 88,380,223 bp
  • A to T, chromosome 10 at 76,062,386 bp
  • A to T, chromosome 10 at 82,739,196 bp
  • A to G, chromosome 10 at 112,458,502 bp
  • A to G, chromosome 11 at 23,649,527 bp
  • A to G, chromosome 11 at 113,688,613 bp
  • T to A, chromosome 12 at 16,659,709 bp
  • T to C, chromosome 12 at 34,287,464 bp
  • G to A, chromosome 12 at 53,141,262 bp
  • A to G, chromosome 12 at 71,075,515 bp
  • G to A, chromosome 13 at 46,694,051 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • A to T, chromosome 14 at 34,092,554 bp
  • T to C, chromosome 15 at 65,948,485 bp
  • T to C, chromosome 15 at 66,696,135 bp
  • A to T, chromosome 15 at 66,787,090 bp
  • G to A, chromosome 15 at 73,557,693 bp
  • T to C, chromosome 17 at 23,310,202 bp
  • T to C, chromosome 17 at 32,403,070 bp
  • A to G, chromosome 18 at 43,437,882 bp
  • T to C, chromosome 18 at 44,158,308 bp
  • A to T, chromosome 19 at 17,178,928 bp
  • T to C, chromosome 19 at 17,439,084 bp
  • A to T, chromosome 19 at 34,307,164 bp
  • A to T, chromosome 19 at 37,922,956 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044945-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.