Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6843Btlr/Mmmh
Stock Number:
044949-MU
Citation ID:
RRID:MMRRC_044949-MU
Other Names:
R6843 (G1)
Major Collection:

Strain Information

Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Hdac1
Name: histone deacetylase 1
Synonyms: RPD3, HD1, MommeD5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Bcl2l13
Name: BCL2 like 13
Synonyms: BCL-RAMBO, Mil1, E430016C20Rik, Mil-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94044
Homologene: 9111
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: liprin beta 2, Cclp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Cep85
Name: centrosomal protein 85
Synonyms: 2410030J07Rik, Ccdc21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70012
Homologene: 11254
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 133,274,878 bp
  • C to A, chromosome 2 at 26,373,599 bp
  • T to G, chromosome 2 at 103,092,489 bp
  • T to C, chromosome 2 at 111,912,915 bp
  • A to T, chromosome 2 at 119,325,994 bp
  • T to A, chromosome 2 at 121,027,685 bp
  • T to C, chromosome 2 at 122,784,980 bp
  • G to T, chromosome 2 at 122,809,295 bp
  • A to G, chromosome 2 at 181,715,754 bp
  • A to C, chromosome 3 at 27,372,527 bp
  • G to A, chromosome 3 at 85,673,045 bp
  • T to A, chromosome 3 at 88,985,388 bp
  • T to A, chromosome 3 at 116,924,215 bp
  • A to G, chromosome 4 at 128,463,794 bp
  • A to G, chromosome 4 at 129,542,590 bp
  • C to G, chromosome 4 at 134,155,856 bp
  • C to T, chromosome 4 at 135,917,589 bp
  • T to C, chromosome 5 at 110,008,715 bp
  • T to C, chromosome 5 at 135,852,281 bp
  • A to G, chromosome 6 at 68,807,686 bp
  • G to A, chromosome 6 at 120,848,617 bp
  • A to T, chromosome 6 at 121,638,401 bp
  • T to A, chromosome 7 at 10,274,765 bp
  • A to G, chromosome 7 at 102,554,721 bp
  • C to T, chromosome 7 at 107,727,731 bp
  • G to T, chromosome 7 at 116,143,320 bp
  • G to A, chromosome 7 at 127,814,979 bp
  • T to A, chromosome 8 at 105,290,097 bp
  • A to T, chromosome 9 at 64,187,691 bp
  • T to C, chromosome 10 at 28,591,982 bp
  • T to C, chromosome 10 at 78,612,057 bp
  • C to A, chromosome 10 at 79,169,668 bp
  • T to A, chromosome 10 at 90,948,598 bp
  • A to G, chromosome 10 at 129,647,179 bp
  • T to G, chromosome 11 at 51,276,249 bp
  • A to G, chromosome 11 at 59,759,728 bp
  • A to G, chromosome 13 at 4,575,214 bp
  • G to T, chromosome 13 at 33,492,917 bp
  • A to G, chromosome 14 at 72,441,211 bp
  • T to G, chromosome 15 at 95,654,459 bp
  • G to A, chromosome 16 at 10,447,020 bp
  • T to A, chromosome 16 at 33,719,526 bp
  • G to A, chromosome 16 at 59,559,796 bp
  • T to A, chromosome 17 at 28,775,453 bp
  • A to G, chromosome 17 at 31,678,173 bp
  • C to T, chromosome 17 at 73,923,130 bp
  • A to G, chromosome 18 at 37,756,325 bp
  • A to T, chromosome 18 at 37,941,954 bp
  • A to T, chromosome 19 at 6,353,447 bp
  • A to G, chromosome 19 at 10,421,771 bp
  • G to T, chromosome 19 at 12,998,998 bp
  • T to C, chromosome 19 at 56,380,219 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6843 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044949-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.