Strain Name:
C57BL/6J-MtgxR6922Btlr/Mmmh
Stock Number:
045041-MU
Citation ID:
RRID:MMRRC_045041-MU
Other Names:
R6922 (G1)
Major Collection:

Strain Information

Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: 4933403M19Rik, PKUalpha, protein kinase U-alpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, repro8, G1-419-52, eIF4GII, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Ago2
Name: argonaute RISC catalytic subunit 2
Synonyms: 2310051F07Rik, argonaute 2, Eif2c2, 1110029L17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239528
HGNC: HGNC:3263
Homologene: 81825
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, Prp8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192159
Homologene: 4706
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 1110031N14Rik, 2810429C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Asb4
Name: ankyrin repeat and SOCS box-containing 4
Synonyms: 8430401O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65255
Homologene: 9392
Hapstr1
Name: HUWE1 associated protein modifying stress responses
Synonyms: 1810013L24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69053
VEGA: 16
Homologene: 105712
Tmprss4
Name: transmembrane protease, serine 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214523
Homologene: 80930
Steap3
Name: STEAP family member 3
Synonyms: 1010001D01Rik, pHyde
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68428
Homologene: 10084
Rdh10
Name: retinol dehydrogenase 10 (all-trans)
Synonyms: D1Ertd762e, 3110069K09Rik, m366Asp, 4921506A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98711
Homologene: 14061
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Camta2
Name: calmodulin binding transcription activator 2
Synonyms: Kiaa0909-hp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216874
Homologene: 9021
Ttll7
Name: tubulin tyrosine ligase-like family, member 7
Synonyms: 1110049N09Rik, 4921517B04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70892
Homologene: 41578
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Birc1f, Naip-rs4A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: AGO, 1110001A17Rik, Fbxo30, SEL-10, Fbxw6, Cdc4, Fbw7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50754
Homologene: 117451
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Or2d36
Name: olfactory receptor family 2 subfamily D member 36
Synonyms: GA_x6K02T2PBJ9-9497411-9498355, MOR260-2, Olfr716
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258597
Homologene: 121514
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Ephb1
Name: Eph receptor B1
Synonyms: Net, Elkh, Elk, C130099E04Rik, Hek6, Cek6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Nuggc
Name: nuclear GTPase, germinal center associated
Synonyms: LOC239151, Gm600, SLIP-GC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100503545
Homologene: 72641
Pld2
Name: phospholipase D2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: 2610209L14Rik, Snf2l2, brm
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
Lhfpl2
Name: lipoma HMGIC fusion partner-like 2
Synonyms: vgim
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218454
HGNC: HGNC:6588
Homologene: 4222
Upf3a
Name: UPF3 regulator of nonsense transcripts homolog A (yeast)
Synonyms: 4930546M19Rik, UPF3, RENT3A, 2600001C03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67031
Homologene: 23395
B3galt4
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Synonyms: Gal-T2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54218
HGNC: HGNC:919
Homologene: 2805
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54201
Homologene: 69231
Cox4i2
Name: cytochrome c oxidase subunit 4I2
Synonyms: Cox IV-2, Cox4b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 84682
Homologene: 13082
Or5w12
Name: olfactory receptor family 5 subfamily W member 12
Synonyms: MOR177-2, GA_x6K02T2Q125-49177531-49176599, Olfr1135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258654
Homologene: 17331
Cd200l1
Name: CD200 molecule like 1
Synonyms: LOC385647, Gm609, iSEC1, LOC208166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208166
Homologene: 86707
Nsun5
Name: NOL1/NOP2/Sun domain family, member 5
Synonyms: Nol1r, 9830109N13Rik, Wbscr20a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100609
Homologene: 6828
Prokr1
Name: prokineticin receptor 1
Synonyms: Pkr1, Gpr73, EG-VEGFR1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58182
HGNC: HGNC:4524
Homologene: 10968
Nim1k
Name: NIM1 serine/threonine protein kinase
Synonyms: Nim1, E130304F04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 245269
VEGA: 13
Homologene: 25286
Pcdhga7
Name: protocadherin gamma subfamily A, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93715
HGNC: HGNC:8705
Homologene: 36377
Gm29106
Name: predicted gene 29106
Type: Gene
Species: Mouse
Chromosome: 1
Eif1ad18
Name: eukaryotic translation initiation factor 1A domain containing 18
Synonyms: Gm16368
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039226
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 16,106,031 bp
  • A to T, chromosome 1 at 118,199,794 bp
  • A to T, chromosome 1 at 120,243,894 bp
  • G to A, chromosome 2 at 76,774,436 bp
  • T to A, chromosome 2 at 87,671,453 bp
  • G to T, chromosome 2 at 152,757,095 bp
  • A to T, chromosome 3 at 84,972,416 bp
  • A to G, chromosome 3 at 146,909,614 bp
  • C to A, chromosome 4 at 82,922,269 bp
  • C to T, chromosome 4 at 138,097,335 bp
  • A to C, chromosome 5 at 135,370,192 bp
  • A to T, chromosome 5 at 143,253,525 bp
  • T to C, chromosome 6 at 5,398,304 bp
  • T to G, chromosome 6 at 48,987,574 bp
  • C to A, chromosome 6 at 87,588,473 bp
  • A to G, chromosome 7 at 107,148,083 bp
  • G to T, chromosome 8 at 13,791,911 bp
  • A to T, chromosome 9 at 32,152,687 bp
  • A to G, chromosome 9 at 45,185,922 bp
  • C to A, chromosome 9 at 101,929,264 bp
  • T to A, chromosome 9 at 103,335,846 bp
  • A to G, chromosome 11 at 70,553,447 bp
  • A to C, chromosome 11 at 70,674,138 bp
  • A to G, chromosome 11 at 75,490,736 bp
  • T to C, chromosome 11 at 105,256,953 bp
  • A to G, chromosome 12 at 85,303,537 bp
  • T to A, chromosome 12 at 88,083,832 bp
  • C to A, chromosome 13 at 12,435,075 bp
  • G to T, chromosome 13 at 94,174,521 bp
  • G to A, chromosome 13 at 100,302,198 bp
  • C to T, chromosome 13 at 119,727,727 bp
  • A to G, chromosome 14 at 61,211,425 bp
  • T to C, chromosome 14 at 64,030,385 bp
  • T to C, chromosome 14 at 65,617,643 bp
  • T to C, chromosome 15 at 73,113,752 bp
  • T to C, chromosome 15 at 100,193,843 bp
  • A to G, chromosome 16 at 8,830,689 bp
  • A to T, chromosome 16 at 45,443,931 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • T to A, chromosome 17 at 33,950,847 bp
  • T to C, chromosome 17 at 71,707,134 bp
  • G to A, chromosome 18 at 10,547,482 bp
  • A to G, chromosome 18 at 37,715,657 bp
  • A to T, chromosome 19 at 3,605,301 bp
  • A to G, chromosome 19 at 26,691,349 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6922 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045041-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.