Strain Name:
C57BL/6J-MtgxR6961Btlr/Mmmh
Stock Number:
045071-MU
Citation ID:
RRID:MMRRC_045071-MU
Other Names:
R6961 (G1)
Major Collection:

Strain Information

Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, Fam188a, 2310047O13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), 9430023P16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Clcn7
Name: chloride channel, voltage-sensitive 7
Synonyms: ClC-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26373
HGNC: HGNC:2025
Homologene: 56546
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Ptbp1
Name: polypyrimidine tract binding protein 1
Synonyms: Ptb, hnRNP I
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19205
HGNC: HGNC:9583
Homologene: 49188
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Cep120
Name: centrosomal protein 120
Synonyms: Ccdc100
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225523
VEGA: 18
Homologene: 27415
Clec1a
Name: C-type lectin domain family 1, member a
Synonyms: 5930406N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243653
Homologene: 9549
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83691
Homologene: 12857
Itsn2
Name: intersectin 2
Synonyms: Ese2, Sh3p18, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Timm17a
Name: translocase of inner mitochondrial membrane 17a
Synonyms: mTim17a, 17kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21854
Homologene: 115910
Hmg20a
Name: high mobility group 20A
Synonyms: Hmgxb1, 1200004E06Rik, 5730490E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66867
VEGA: 9
HGNC: HGNC:5001
Homologene: 32399
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Klhl8
Name: kelch-like 8
Synonyms: D5Ertd431e, 2310001P09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246293
Homologene: 10819
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf181, nmf252, nmf112, ahl, mdfw, USH1D, bob, sals, 4930542A03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: Pla2epsilon, 2310026J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329502
Homologene: 65339
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Slc45a1
Name: solute carrier family 45, member 1
Synonyms: Dnb5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242773
Homologene: 44908
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Gababrbp, Marlin-1, 5830437M04Rik, C330021K24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: D430008P04Rik, tie-1, TIE
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21846
Homologene: 3957
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Fut1
Name: fucosyltransferase 1
Synonyms: H transferase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14343
HGNC: HGNC:4012
Homologene: 120
Or52s19
Name: olfactory receptor family 52 subfamily S member 19
Synonyms: Olfr601, GA_x6K02T2PBJ9-6068534-6067590, MOR24-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258311
Homologene: 64851
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: C230078M14Rik, Caspr5-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Or52b1
Name: olfactory receptor family 52 subfamily B member 1
Synonyms: GA_x6K02T2PBJ9-7959171-7958224, MOR31-2, Olfr690
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56860
Homologene: 10653
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Baiap2l2
Name: BAI1-associated protein 2-like 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207495
Homologene: 11811
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53791
Homologene: 20698
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Ttc29
Name: tetratricopeptide repeat domain 29
Synonyms: 1700031F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73301
Homologene: 12918
Cd200l1
Name: CD200 molecule like 1
Synonyms: LOC208166, Gm609, LOC385647, iSEC1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208166
Homologene: 86707
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: IL15Rbeta, CD122, IL-2/15Rbeta, IL-15Rbeta, IL-15 receptor beta chain, Il-2Rbeta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Or4c115
Name: olfactory receptor family 4 subfamily C member 115
Synonyms: GA_x6K02T2Q125-50579531-50578596, Olfr1220, MOR233-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258902
Homologene: 74242
Or2y3
Name: olfactory receptor family 2 subfamily Y member 3
Synonyms: GA_x6K02T2PSCP-2531299-2530355, Olfr131, MOR256-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258867
Homologene: 105889
Napa
Name: N-ethylmaleimide sensitive fusion protein attachment protein alpha
Synonyms: a-SNAP, SNARE, hyh, RA81, 1500039N14Rik, SNAPA
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108124
HGNC: HGNC:7641
Homologene: 2839
Nudt21
Name: nudix hydrolase 21
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 21, 5730530J16Rik, Cpsf5, 25kDa, 3110048P04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68219
Homologene: 5090
Or56a41
Name: olfactory receptor family 56 subfamily A member 41, pseudogene 1
Synonyms: MOR40-10P, Olfr680, GA_x6K02T2PBJ9-7720330-7719479
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257981
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgfb-2, Tgf-beta2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21808
Homologene: 2432
Cldn12
Name: claudin 12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64945
HGNC: HGNC:2034
Homologene: 40809
Atp6v0d1
Name: ATPase, H+ transporting, lysosomal V0 subunit D1
Synonyms: lysosomal 38kDa, Vma6, P39, Ac39, Atp6d
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11972
Homologene: 3444
Pate13
Name: prostate and testis expressed 13
Synonyms: 9230113P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77908
Gm29106
Name: predicted gene 29106
Type: Gene
Species: Mouse
Chromosome: 1
Or6c7
Name: olfactory receptor family 6 subfamily C member 7
Synonyms: GA_x6K02T2PULF-11165842-11166815, MOR111-9P, Olfr789, Olfr789-ps1, MOR111-13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258148
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 17,762,141 bp
  • A to G, chromosome 1 at 100,274,472 bp
  • A to T, chromosome 1 at 118,200,398 bp
  • A to G, chromosome 1 at 135,311,078 bp
  • A to T, chromosome 1 at 152,841,583 bp
  • C to T, chromosome 1 at 182,973,511 bp
  • A to T, chromosome 1 at 186,649,835 bp
  • C to A, chromosome 2 at 12,396,178 bp
  • A to G, chromosome 2 at 22,245,558 bp
  • T to A, chromosome 2 at 89,097,805 bp
  • G to T, chromosome 2 at 120,174,370 bp
  • T to A, chromosome 3 at 36,050,617 bp
  • C to T, chromosome 4 at 118,486,205 bp
  • T to C, chromosome 4 at 150,629,653 bp
  • A to T, chromosome 5 at 5,507,707 bp
  • A to G, chromosome 5 at 21,543,742 bp
  • T to C, chromosome 5 at 37,173,353 bp
  • A to C, chromosome 5 at 74,519,541 bp
  • A to G, chromosome 5 at 76,876,301 bp
  • T to C, chromosome 5 at 103,870,569 bp
  • T to A, chromosome 6 at 48,463,877 bp
  • C to T, chromosome 6 at 129,429,983 bp
  • T to C, chromosome 7 at 3,825,125 bp
  • C to T, chromosome 7 at 16,109,109 bp
  • A to T, chromosome 7 at 45,619,539 bp
  • A to G, chromosome 7 at 97,541,190 bp
  • A to G, chromosome 7 at 103,358,582 bp
  • A to T, chromosome 7 at 105,092,771 bp
  • A to T, chromosome 7 at 105,329,706 bp
  • G to A, chromosome 8 at 15,117,741 bp
  • A to C, chromosome 8 at 78,276,916 bp
  • A to C, chromosome 8 at 94,028,880 bp
  • A to G, chromosome 8 at 105,529,217 bp
  • G to A, chromosome 9 at 35,908,444 bp
  • T to C, chromosome 9 at 56,488,728 bp
  • A to G, chromosome 10 at 41,455,175 bp
  • G to C, chromosome 10 at 60,650,114 bp
  • T to C, chromosome 10 at 79,859,277 bp
  • T to C, chromosome 10 at 89,413,291 bp
  • T to C, chromosome 10 at 129,487,462 bp
  • T to A, chromosome 12 at 4,673,420 bp
  • T to C, chromosome 12 at 103,112,915 bp
  • T to A, chromosome 15 at 78,485,824 bp
  • A to G, chromosome 15 at 79,284,635 bp
  • T to A, chromosome 15 at 99,940,201 bp
  • T to A, chromosome 16 at 45,444,003 bp
  • A to T, chromosome 17 at 20,268,384 bp
  • C to T, chromosome 17 at 25,157,214 bp
  • T to A, chromosome 17 at 38,082,205 bp
  • A to T, chromosome 18 at 20,038,222 bp
  • C to A, chromosome 18 at 53,703,205 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6961 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045071-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.