Strain Name:
C57BL/6J-MtgxR7042Btlr/Mmmh
Stock Number:
045141-MU
Citation ID:
RRID:MMRRC_045141-MU
Other Names:
R7042 (G1)
Major Collection:

Strain Information

Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Pax6
Name: paired box 6
Synonyms: Pax-6, Dey, Dickie's small eye, 1500038E17Rik, AEY11, Gsfaey11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: CLC-K1, Clcnk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12733
Homologene: 65
Hcrtr1
Name: hypocretin (orexin) receptor 1
Synonyms: OX1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230777
HGNC: HGNC:4848
Homologene: 37492
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Etf1
Name: eukaryotic translation termination factor 1
Synonyms: SUP45L1, TB3-1, ERF1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225363
HGNC: HGNC:3477
Homologene: 3475
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22323
Homologene: 7592
Dhx38
Name: DEAH-box helicase 38
Synonyms: Prp16, Ddx38, 5730550P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64340
Homologene: 8512
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: LL5A, D330037A14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, 3830418C19Rik, Smc6l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms: Kir3.1, GIRK1, Kcnf3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16519
HGNC: HGNC:6264
Homologene: 1687
Klrk1
Name: killer cell lectin-like receptor subfamily K, member 1
Synonyms: NKG2-D, Nkg2d, D6H12S2489E
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27007
Homologene: 7209
Wdr18
Name: WD repeat domain 18
Synonyms: 2310012I10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216156
VEGA: 10
Homologene: 32573
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: D430033N04Rik, Wdr60, Dync2l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Sec22a
Name: SEC22 homolog A, vesicle trafficking protein
Synonyms: 1810005C06Rik, Sec22l2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 317717
Homologene: 8246
Ier3ip1
Name: immediate early response 3 interacting protein 1
Synonyms: 1110057H19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66191
Homologene: 41106
Ebf1
Name: early B cell factor 1
Synonyms: Olf-1, O/E-1, Olf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13591
HGNC: HGNC:3126
Homologene: 7297
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: FATP2, VLCS, FATP2, Vlacs, Vlac, ACSVL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26458
Homologene: 37830
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Ttc39d
Name: tetratricopeptide repeat domain 39D
Synonyms: 4930560E09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67737
Homologene: 65053
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-1, Aox-2, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Fmo2
Name: flavin containing monooxygenase 2
Synonyms: 2310008D08Rik, 2310042I22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 55990
HGNC: HGNC:3770
Homologene: 86882
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Or8d23
Name: olfactory receptor family 8 subfamily D member 23
Synonyms: GA_x6K02T2PVTD-32626123-32627049, MOR171-46, Olfr930
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258269
VEGA: 9
HGNC: HGNC:8481
Homologene: 138304
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75453
Homologene: 49919
Rem2
Name: rad and gem related GTP binding protein 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140743
Homologene: 11222
Ppp3cc
Name: protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms: PP2BA gamma, Calnc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19057
VEGA: 14
HGNC: HGNC:9316
Homologene: 68475
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
Synonyms: 1700061G19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78625
Homologene: 28378
Spice1
Name: spindle and centriole associated protein 1
Synonyms: D16Ertd480e, Ccdc52
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212514
Homologene: 16931
Vcpip1
Name: valosin containing protein (p97)/p47 complex interacting protein 1
Synonyms: 5730421J18Rik, 5730538E15Rik, Vcip135
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70675
Homologene: 11814
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Nlrp5
Name: NLR family, pyrin domain containing 5
Synonyms: Op1, Mater, Nalp5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23968
Homologene: 65105
Plscr1
Name: phospholipid scramblase 1
Synonyms: MmTRA1b, MmTRA1a, NOR1, TRA1, Tras2, Tras1, MuPLSCR2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22038
HGNC: HGNC:9092
Homologene: 41418
Or5w12
Name: olfactory receptor family 5 subfamily W member 12
Synonyms: GA_x6K02T2Q125-49177531-49176599, MOR177-2, Olfr1135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258654
Homologene: 17331
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: 9130206P09Rik, RIP11, GAF1, D6Ertd32e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52055
Homologene: 9158
Pgc
Name: progastricsin (pepsinogen C)
Synonyms: Upg-1, Upg1, 2210410L06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 109820
HGNC: HGNC:8890
Homologene: 55669
Foxl2
Name: forkhead box L2
Synonyms: Pfrk
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26927
HGNC: HGNC:1092
Homologene: 74992
Ifi209
Name: interferon activated gene 209
Synonyms: Ifix, Pyhin1, Pyhin-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 236312
HGNC: HGNC:5395
Homologene: 115929
Dcxr
Name: dicarbonyl L-xylulose reductase
Synonyms: 1810027P18Rik, 0610038K04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67880
Homologene: 22964
Gpr61
Name: G protein-coupled receptor 61
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229714
Homologene: 12910
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Or8b3
Name: olfactory receptor family 8 subfamily B member 3
Synonyms: M3, GA_x6K02T2PVTD-32098059-32099003, MOR164-1, Olfr147
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258869
VEGA: 9
Homologene: 128279
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Pick1
Name: protein interacting with C kinase 1
Synonyms: Prkcabp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18693
HGNC: HGNC:9394
Homologene: 7470
Gm3404
Name: predicted gene 3404
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041554
Homologene: 86127
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: GA_x6K02T2Q125-49911636-49910701, MOR225-9P, Olfr1181
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Qpctl
Name: glutaminyl-peptide cyclotransferase-like
Synonyms: 1810019P04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67369
Homologene: 9765
Cst8
Name: cystatin 8 (cystatin-related epididymal spermatogenic)
Synonyms: Cst-rs1, Cres
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13012
HGNC: HGNC:2480
Homologene: 4011
Slfn14
Name: schlafen 14
Synonyms: LOC237890, Slfn14-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237890
Homologene: 19082
Mfsd4b4
Name: major facilitator superfamily domain containing 4B4
Synonyms: AA474331
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213332
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 9,748,153 bp
  • A to T, chromosome 1 at 33,777,393 bp
  • A to T, chromosome 1 at 58,102,600 bp
  • A to G, chromosome 1 at 162,880,657 bp
  • G to A, chromosome 1 at 173,481,242 bp
  • G to A, chromosome 1 at 173,642,670 bp
  • A to T, chromosome 2 at 55,594,865 bp
  • T to C, chromosome 2 at 67,513,289 bp
  • A to T, chromosome 2 at 87,671,591 bp
  • T to A, chromosome 2 at 88,423,402 bp
  • A to T, chromosome 2 at 105,696,373 bp
  • C to T, chromosome 2 at 126,567,780 bp
  • T to A, chromosome 2 at 148,799,876 bp
  • A to T, chromosome 3 at 95,750,745 bp
  • G to A, chromosome 3 at 108,151,331 bp
  • A to G, chromosome 4 at 130,130,860 bp
  • A to G, chromosome 4 at 141,391,380 bp
  • A to G, chromosome 5 at 6,770,042 bp
  • T to A, chromosome 5 at 120,663,960 bp
  • A to T, chromosome 5 at 146,526,159 bp
  • A to G, chromosome 6 at 85,374,128 bp
  • A to T, chromosome 6 at 129,616,771 bp
  • T to C, chromosome 7 at 19,147,018 bp
  • A to G, chromosome 7 at 19,262,021 bp
  • A to G, chromosome 7 at 23,417,480 bp
  • G to T, chromosome 8 at 88,315,750 bp
  • A to T, chromosome 8 at 109,556,985 bp
  • T to A, chromosome 8 at 129,085,249 bp
  • G to T, chromosome 9 at 38,402,900 bp
  • A to G, chromosome 9 at 38,930,326 bp
  • A to G, chromosome 9 at 44,694,424 bp
  • A to G, chromosome 9 at 92,271,535 bp
  • T to A, chromosome 9 at 98,955,662 bp
  • T to A, chromosome 10 at 39,892,518 bp
  • A to T, chromosome 10 at 79,966,110 bp
  • A to T, chromosome 10 at 105,370,616 bp
  • T to A, chromosome 11 at 44,991,511 bp
  • T to A, chromosome 11 at 83,276,604 bp
  • T to C, chromosome 11 at 120,727,015 bp
  • T to A, chromosome 12 at 11,309,300 bp
  • T to C, chromosome 12 at 115,623,289 bp
  • T to C, chromosome 12 at 116,254,441 bp
  • T to A, chromosome 14 at 54,478,091 bp
  • T to G, chromosome 14 at 70,225,019 bp
  • T to C, chromosome 15 at 79,248,765 bp
  • T to A, chromosome 16 at 35,329,515 bp
  • T to C, chromosome 16 at 44,385,680 bp
  • T to C, chromosome 17 at 19,080,922 bp
  • C to A, chromosome 17 at 47,733,820 bp
  • A to G, chromosome 17 at 56,885,098 bp
  • C to A, chromosome 17 at 80,216,462 bp
  • T to C, chromosome 17 at 83,461,570 bp
  • T to C, chromosome 18 at 34,910,166 bp
  • T to A, chromosome 18 at 76,930,132 bp
  • T to C, chromosome 18 at 79,086,855 bp
  • T to C, chromosome 19 at 42,104,898 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7042 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045141-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.