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Strain Name:
C57BL/6J-MtgxR7042Btlr/Mmmh
Stock Number:
045141-MU
Citation ID:
RRID:MMRRC_045141-MU
Other Names:
R7042 (G1)
Major Collection:

Strain Information

Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Pax6
Name: paired box 6
Synonyms: Pax-6, Dey, Dickie's small eye, 1500038E17Rik, AEY11, Gsfaey11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: CLC-K1, Clcnk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12733
Homologene: 65
Hcrtr1
Name: hypocretin (orexin) receptor 1
Synonyms: OX1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230777
HGNC: HGNC:4848
Homologene: 37492
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Etf1
Name: eukaryotic translation termination factor 1
Synonyms: SUP45L1, TB3-1, ERF1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225363
HGNC: HGNC:3477
Homologene: 3475
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22323
Homologene: 7592
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 9,748,153 bp
  • A to T, chromosome 1 at 33,777,393 bp
  • A to T, chromosome 1 at 58,102,600 bp
  • A to G, chromosome 1 at 162,880,657 bp
  • G to A, chromosome 1 at 173,481,242 bp
  • G to A, chromosome 1 at 173,642,670 bp
  • A to T, chromosome 2 at 55,594,865 bp
  • T to C, chromosome 2 at 67,513,289 bp
  • A to T, chromosome 2 at 87,671,591 bp
  • T to A, chromosome 2 at 88,423,402 bp
  • A to T, chromosome 2 at 105,696,373 bp
  • C to T, chromosome 2 at 126,567,780 bp
  • T to A, chromosome 2 at 148,799,876 bp
  • A to T, chromosome 3 at 95,750,745 bp
  • G to A, chromosome 3 at 108,151,331 bp
  • A to G, chromosome 4 at 130,130,860 bp
  • A to G, chromosome 4 at 141,391,380 bp
  • A to G, chromosome 5 at 6,770,042 bp
  • T to A, chromosome 5 at 120,663,960 bp
  • A to T, chromosome 5 at 146,526,159 bp
  • A to G, chromosome 6 at 85,374,128 bp
  • A to T, chromosome 6 at 129,616,771 bp
  • T to C, chromosome 7 at 19,147,018 bp
  • A to G, chromosome 7 at 19,262,021 bp
  • A to G, chromosome 7 at 23,417,480 bp
  • G to T, chromosome 8 at 88,315,750 bp
  • A to T, chromosome 8 at 109,556,985 bp
  • T to A, chromosome 8 at 129,085,249 bp
  • G to T, chromosome 9 at 38,402,900 bp
  • A to G, chromosome 9 at 38,930,326 bp
  • A to G, chromosome 9 at 44,694,424 bp
  • A to G, chromosome 9 at 92,271,535 bp
  • T to A, chromosome 9 at 98,955,662 bp
  • T to A, chromosome 10 at 39,892,518 bp
  • A to T, chromosome 10 at 79,966,110 bp
  • A to T, chromosome 10 at 105,370,616 bp
  • T to A, chromosome 11 at 44,991,511 bp
  • T to A, chromosome 11 at 83,276,604 bp
  • T to C, chromosome 11 at 120,727,015 bp
  • T to A, chromosome 12 at 11,309,300 bp
  • T to C, chromosome 12 at 115,623,289 bp
  • T to C, chromosome 12 at 116,254,441 bp
  • T to A, chromosome 14 at 54,478,091 bp
  • T to G, chromosome 14 at 70,225,019 bp
  • T to C, chromosome 15 at 79,248,765 bp
  • T to A, chromosome 16 at 35,329,515 bp
  • T to C, chromosome 16 at 44,385,680 bp
  • T to C, chromosome 17 at 19,080,922 bp
  • C to A, chromosome 17 at 47,733,820 bp
  • A to G, chromosome 17 at 56,885,098 bp
  • C to A, chromosome 17 at 80,216,462 bp
  • T to C, chromosome 17 at 83,461,570 bp
  • T to C, chromosome 18 at 34,910,166 bp
  • T to A, chromosome 18 at 76,930,132 bp
  • T to C, chromosome 18 at 79,086,855 bp
  • T to C, chromosome 19 at 42,104,898 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7042 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045141-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.