Strain Name:
C57BL/6J-MtgxR6923Btlr/Mmmh
Stock Number:
045381-MU
Citation ID:
RRID:MMRRC_045381-MU
Other Names:
R6923 (G1)
Major Collection:

Strain Information

Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: Su(Fu), 2810026F04Rik, b2b273Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24069
Homologene: 9262
Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Fkbp2
Name: FK506 binding protein 2
Synonyms: mFKBP2, mFKBP13, 13kDa
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14227
VEGA: 19
HGNC: HGNC:3718
Homologene: 40604
Pax4
Name: paired box 4
Synonyms: Pax-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18506
HGNC: HGNC:8618
Homologene: 4515
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: C330013D05Rik, MTGR1, Cbfa2t2h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, Prkwnk1, 6430573H23Rik, EG406236
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Prpf38a
Name: PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
Synonyms: 2410002M20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230596
Homologene: 13146
Scamp2
Name: secretory carrier membrane protein 2
Synonyms: Sc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24044
VEGA: 9
Homologene: 4163
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Orc2
Name: origin recognition complex, subunit 2
Synonyms: Orc2l
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18393
HGNC: HGNC:8488
Homologene: 4512
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Nkapd1
Name: NKAP domain containing 1
Synonyms: LOC270156, AU019823
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270156
Homologene: 41233
Atg16l1
Name: autophagy related 16 like 1
Synonyms: APG16L, WDR30, 1500009K01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77040
Homologene: 41786
Cenpa
Name: centromere protein A
Synonyms: Cenp-A, centrosomin A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12615
HGNC: HGNC:1851
Homologene: 1369
Jph3
Name: junctophilin 3
Synonyms: JP-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57340
Homologene: 10762
Syt2
Name: synaptotagmin II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20980
Homologene: 22516
Yy1
Name: YY1 transcription factor
Synonyms: UCRBP transcription factor, NF-E1, delta transcription factor, Yin Yang 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22632
Homologene: 2556
Bloc1s5
Name: biogenesis of lysosomal organelles complex-1, subunit 5, muted
Synonyms: BLOC-1 subunit, 1810074A19Rik, mu, Muted
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17828
VEGA: 13
Homologene: 16374
Firrm
Name: FIGNL1 interacting regulator of recombination and mitosis
Synonyms: FLIP, BC055324
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381306
Homologene: 10058
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Tfeb
Name: transcription factor EB
Synonyms: Tcfeb, bHLHe35, TFEB
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21425
Homologene: 5182
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 620779
Homologene: 51847
Ap4b1
Name: adaptor-related protein complex AP-4, beta 1
Synonyms: AP-4 beta-4, 1810038H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67489
HGNC: HGNC:572
Homologene: 38203
Me3
Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms: 1700020C08Rik, B230207H15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109264
HGNC: HGNC:6985
Homologene: 100773
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 1700012M13Rik, 4933432K11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71313
Homologene: 12390
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Albfm1
Name: albumin superfamily member 1
Synonyms: ARG, 5830473C10Rik, Gm17754
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622307
Homologene: 129803
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, Pla2g1br, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Or5b94
Name: olfactory receptor family 5 subfamily B member 94
Synonyms: MOR202-9, GA_x6K02T2RE5P-3000589-3001527, Olfr1442
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258692
Homologene: 138315
Zc3h15
Name: zinc finger CCCH-type containing 15
Synonyms: FM22, 2610312B22Rik, 1700006A17Rik, Ierepo4, 1810012H02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69082
Homologene: 10216
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277667
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I beta, A230068P09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69922
Homologene: 55966
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: 4930558F19Rik, LOC100045280, 9130422H11Rik, Ih
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50770
Homologene: 75050
Gm4922
Name: predicted gene 4922
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237300
VEGA: 10
Homologene: 50497
Capn5
Name: calpain 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12337
HGNC: HGNC:1482
Homologene: 31212
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Or5b97
Name: olfactory receptor family 5 subfamily B member 97
Synonyms: Olfr1447, GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258698
HGNC: HGNC:8324
Homologene: 74233
Gbp2b
Name: guanylate binding protein 2b
Synonyms: Gbp1, Gbp-1, Mag-1, Mpa1, Mpa-1, LIMIT
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14468
Homologene: 137233
Gpatch3
Name: G patch domain containing 3
Synonyms: D930035B09Rik, Gpatc3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242691
Homologene: 11122
Semp2l2b
Name: SUMO/sentrin specific peptidase 2-like 2B
Synonyms: 4930444G20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114671
Homologene: 130042
Chit1
Name: chitinase 1
Synonyms: 2300002L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Hdac1-ps
Name: histone deacetylase 1, pseudogene
Synonyms: Gm10093, EG15181
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15181
VEGA: 17
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
Spem2
Name: SPEM family member 2
Synonyms: 4933402P03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108803
Homologene: 52178
Cd3d
Name: CD3 antigen, delta polypeptide
Synonyms: T3d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12500
VEGA: 9
HGNC: HGNC:1673
Homologene: 585
Msantd5l
Name: Myb/SANT DNA binding domain containing 5 like
Synonyms: BC049762
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193286
Homologene: 77615
S100z
Name: S100 calcium binding protein, zeta
Synonyms: LOC268686
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268686
VEGA: 13
Homologene: 15633
Rdh16f1
Name: RDH16 family member 1
Synonyms: Gm28046
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,500,375 bp
  • A to T, chromosome 1 at 87,774,356 bp
  • A to T, chromosome 1 at 134,149,425 bp
  • T to C, chromosome 1 at 134,746,763 bp
  • A to G, chromosome 1 at 163,986,885 bp
  • A to C, chromosome 1 at 173,884,698 bp
  • A to G, chromosome 2 at 52,186,064 bp
  • G to A, chromosome 2 at 57,355,788 bp
  • C to T, chromosome 2 at 60,514,966 bp
  • A to G, chromosome 2 at 83,657,056 bp
  • G to A, chromosome 2 at 118,249,913 bp
  • C to T, chromosome 2 at 154,534,983 bp
  • T to A, chromosome 3 at 103,812,214 bp
  • C to T, chromosome 3 at 133,479,341 bp
  • T to C, chromosome 3 at 142,600,559 bp
  • T to C, chromosome 4 at 96,769,816 bp
  • G to T, chromosome 4 at 108,570,204 bp
  • C to T, chromosome 4 at 133,582,525 bp
  • A to T, chromosome 4 at 143,699,106 bp
  • A to G, chromosome 5 at 30,672,462 bp
  • A to G, chromosome 5 at 90,577,793 bp
  • A to G, chromosome 6 at 28,447,119 bp
  • A to T, chromosome 6 at 119,965,678 bp
  • T to G, chromosome 7 at 79,691,853 bp
  • C to A, chromosome 7 at 89,845,885 bp
  • T to A, chromosome 7 at 98,129,254 bp
  • C to T, chromosome 7 at 141,637,540 bp
  • A to G, chromosome 8 at 12,856,949 bp
  • G to A, chromosome 8 at 85,518,052 bp
  • A to G, chromosome 8 at 121,753,371 bp
  • T to C, chromosome 9 at 44,985,859 bp
  • T to A, chromosome 9 at 50,610,310 bp
  • T to G, chromosome 9 at 57,581,612 bp
  • T to A, chromosome 9 at 70,574,610 bp
  • T to C, chromosome 10 at 18,783,868 bp
  • C to A, chromosome 10 at 22,067,755 bp
  • T to A, chromosome 10 at 127,788,868 bp
  • G to A, chromosome 11 at 26,489,893 bp
  • C to T, chromosome 11 at 51,253,981 bp
  • C to T, chromosome 11 at 69,735,961 bp
  • T to A, chromosome 11 at 69,817,777 bp
  • C to G, chromosome 11 at 74,929,343 bp
  • T to A, chromosome 11 at 78,274,626 bp
  • A to T, chromosome 12 at 108,793,668 bp
  • T to A, chromosome 13 at 38,631,064 bp
  • T to A, chromosome 13 at 95,478,582 bp
  • G to T, chromosome 14 at 57,603,711 bp
  • T to G, chromosome 16 at 22,011,576 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • T to A, chromosome 17 at 47,786,983 bp
  • T to A, chromosome 17 at 58,092,350 bp
  • A to G, chromosome 17 at 78,492,914 bp
  • G to A, chromosome 17 at 91,088,233 bp
  • C to T, chromosome 18 at 37,342,469 bp
  • A to G, chromosome 19 at 6,979,169 bp
  • T to A, chromosome 19 at 12,675,045 bp
  • T to C, chromosome 19 at 12,901,312 bp
  • A to T, chromosome 19 at 25,095,606 bp
  • A to G, chromosome 19 at 46,450,966 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6923 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045381-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.