Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7485Btlr/Mmmh
Stock Number:
045559-MU
Citation ID:
RRID:MMRRC_045559-MU
Other Names:
R7485 (G1)
Major Collection:

Strain Information

Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Fam131a
Name: family with sequence similarity 131, member A
Synonyms: 2900046G09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78408
Homologene: 82234
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: nucling, 2700059D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,274,189 bp
  • A to G, chromosome 1 at 40,480,980 bp
  • G to A, chromosome 1 at 67,139,857 bp
  • A to G, chromosome 1 at 79,614,301 bp
  • G to T, chromosome 1 at 92,876,657 bp
  • A to G, chromosome 1 at 191,396,335 bp
  • T to C, chromosome 2 at 13,216,875 bp
  • A to G, chromosome 2 at 25,584,141 bp
  • T to A, chromosome 2 at 36,734,638 bp
  • T to A, chromosome 2 at 66,534,217 bp
  • A to T, chromosome 2 at 70,531,765 bp
  • T to A, chromosome 2 at 158,443,355 bp
  • A to G, chromosome 2 at 181,423,719 bp
  • T to A, chromosome 3 at 95,495,348 bp
  • A to T, chromosome 3 at 103,833,413 bp
  • T to C, chromosome 4 at 107,165,655 bp
  • T to C, chromosome 4 at 107,297,677 bp
  • T to C, chromosome 4 at 139,784,569 bp
  • G to A, chromosome 4 at 140,027,738 bp
  • A to G, chromosome 4 at 141,840,316 bp
  • A to G, chromosome 5 at 5,508,008 bp
  • A to G, chromosome 5 at 87,327,680 bp
  • A to T, chromosome 5 at 113,279,635 bp
  • G to T, chromosome 5 at 115,663,786 bp
  • T to A, chromosome 5 at 121,495,061 bp
  • T to A, chromosome 5 at 123,786,956 bp
  • T to A, chromosome 6 at 28,531,450 bp
  • T to C, chromosome 6 at 41,202,927 bp
  • A to G, chromosome 6 at 57,581,104 bp
  • C to T, chromosome 6 at 83,116,207 bp
  • C to T, chromosome 6 at 83,189,905 bp
  • A to G, chromosome 6 at 91,270,161 bp
  • C to T, chromosome 7 at 5,359,441 bp
  • T to C, chromosome 7 at 15,833,938 bp
  • T to A, chromosome 7 at 20,023,950 bp
  • C to T, chromosome 7 at 24,611,264 bp
  • G to T, chromosome 7 at 25,380,611 bp
  • C to A, chromosome 7 at 48,811,355 bp
  • A to T, chromosome 7 at 76,589,493 bp
  • T to C, chromosome 7 at 81,900,358 bp
  • T to C, chromosome 7 at 90,223,930 bp
  • A to T, chromosome 7 at 98,498,207 bp
  • C to T, chromosome 7 at 105,749,544 bp
  • C to A, chromosome 7 at 108,255,838 bp
  • A to C, chromosome 7 at 114,245,485 bp
  • C to A, chromosome 7 at 131,228,833 bp
  • T to A, chromosome 7 at 140,610,178 bp
  • C to T, chromosome 8 at 13,140,279 bp
  • A to T, chromosome 8 at 13,386,732 bp
  • A to T, chromosome 8 at 14,829,952 bp
  • T to C, chromosome 8 at 41,084,553 bp
  • A to T, chromosome 8 at 80,613,336 bp
  • A to T, chromosome 9 at 14,782,541 bp
  • A to T, chromosome 9 at 15,863,294 bp
  • T to C, chromosome 9 at 37,315,278 bp
  • A to C, chromosome 9 at 58,884,543 bp
  • G to A, chromosome 9 at 60,846,000 bp
  • A to G, chromosome 9 at 63,508,317 bp
  • T to C, chromosome 9 at 99,661,012 bp
  • A to T, chromosome 10 at 76,039,241 bp
  • A to T, chromosome 10 at 76,221,004 bp
  • C to T, chromosome 10 at 80,606,400 bp
  • T to A, chromosome 10 at 128,632,582 bp
  • C to A, chromosome 11 at 8,965,148 bp
  • C to T, chromosome 11 at 57,513,689 bp
  • A to G, chromosome 11 at 58,978,637 bp
  • C to T, chromosome 11 at 75,508,912 bp
  • A to G, chromosome 11 at 77,973,885 bp
  • A to G, chromosome 11 at 99,948,974 bp
  • A to G, chromosome 11 at 101,337,403 bp
  • T to A, chromosome 11 at 115,354,719 bp
  • T to C, chromosome 12 at 55,712,672 bp
  • T to A, chromosome 13 at 23,855,849 bp
  • A to G, chromosome 13 at 27,574,085 bp
  • T to C, chromosome 13 at 100,283,851 bp
  • A to G, chromosome 14 at 21,792,423 bp
  • A to T, chromosome 14 at 24,148,322 bp
  • A to T, chromosome 14 at 24,177,839 bp
  • A to T, chromosome 15 at 8,330,295 bp
  • A to T, chromosome 15 at 43,867,365 bp
  • A to T, chromosome 15 at 66,696,588 bp
  • T to C, chromosome 15 at 76,537,913 bp
  • T to A, chromosome 15 at 85,868,700 bp
  • C to T, chromosome 16 at 20,701,694 bp
  • G to T, chromosome 16 at 38,588,296 bp
  • A to T, chromosome 16 at 59,345,324 bp
  • A to T, chromosome 16 at 76,291,450 bp
  • T to A, chromosome 16 at 97,545,718 bp
  • G to T, chromosome 17 at 20,029,475 bp
  • A to T, chromosome 17 at 24,249,258 bp
  • T to C, chromosome 17 at 25,826,127 bp
  • G to A, chromosome 17 at 32,335,571 bp
  • A to G, chromosome 18 at 24,506,832 bp
  • T to C, chromosome 18 at 58,071,840 bp
  • T to A, chromosome 18 at 69,969,013 bp
  • A to G, chromosome 18 at 71,420,246 bp
  • C to T, chromosome 19 at 12,999,558 bp
  • A to T, chromosome 19 at 37,410,624 bp
  • A to T, chromosome 19 at 37,951,491 bp
  • A to T, chromosome 19 at 39,807,606 bp
  • A to G, chromosome 19 at 58,300,312 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7485 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045559-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.