Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7765Btlr/Mmmh
Stock Number:
045821-MU
Citation ID:
RRID:MMRRC_045821-MU
Other Names:
R7765 (G1)
Major Collection:

Strain Information

Ntsr1
Name: neurotensin receptor 1
Synonyms: NT-1R, Ntsr1, NTR-1, NTR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: InsP6, 1200016D08Rik, Ihpk1, InsP6k1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27399
Homologene: 56602
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Lefty1
Name: left right determination factor 1
Synonyms: lefty-1, Stra3, Lefty, Ebaf
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Ddx27
Name: DEAD box helicase 27
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228889
Homologene: 6431
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,275,694 bp
  • C to T, chromosome 1 at 75,216,359 bp
  • T to G, chromosome 1 at 107,079,782 bp
  • T to G, chromosome 1 at 121,499,313 bp
  • T to A, chromosome 1 at 130,874,288 bp
  • G to A, chromosome 1 at 156,524,784 bp
  • A to T, chromosome 1 at 173,524,836 bp
  • A to G, chromosome 1 at 180,936,547 bp
  • T to A, chromosome 2 at 86,978,194 bp
  • G to A, chromosome 2 at 109,306,940 bp
  • A to G, chromosome 2 at 153,843,190 bp
  • T to A, chromosome 2 at 167,027,959 bp
  • T to A, chromosome 2 at 180,538,817 bp
  • T to C, chromosome 3 at 20,091,483 bp
  • T to A, chromosome 3 at 84,444,599 bp
  • A to G, chromosome 3 at 122,275,945 bp
  • T to A, chromosome 4 at 117,760,615 bp
  • T to C, chromosome 4 at 141,874,575 bp
  • T to G, chromosome 5 at 108,314,054 bp
  • A to T, chromosome 5 at 121,662,129 bp
  • T to C, chromosome 6 at 54,298,152 bp
  • G to A, chromosome 7 at 44,909,736 bp
  • T to C, chromosome 7 at 72,090,331 bp
  • T to G, chromosome 7 at 139,651,564 bp
  • A to G, chromosome 8 at 64,051,449 bp
  • A to G, chromosome 8 at 72,204,425 bp
  • C to A, chromosome 8 at 75,000,808 bp
  • A to C, chromosome 9 at 35,669,901 bp
  • A to G, chromosome 9 at 39,470,316 bp
  • A to T, chromosome 9 at 45,941,575 bp
  • A to G, chromosome 9 at 108,032,089 bp
  • A to G, chromosome 9 at 119,609,904 bp
  • A to G, chromosome 10 at 42,574,437 bp
  • C to T, chromosome 10 at 43,464,632 bp
  • C to T, chromosome 10 at 62,665,999 bp
  • A to G, chromosome 10 at 91,023,782 bp
  • T to A, chromosome 10 at 116,113,253 bp
  • A to G, chromosome 11 at 49,327,744 bp
  • C to T, chromosome 11 at 59,758,221 bp
  • T to A, chromosome 11 at 67,303,655 bp
  • A to T, chromosome 11 at 84,994,408 bp
  • T to A, chromosome 11 at 116,053,082 bp
  • T to C, chromosome 12 at 30,958,869 bp
  • T to C, chromosome 12 at 79,803,270 bp
  • A to G, chromosome 12 at 89,813,484 bp
  • T to G, chromosome 13 at 13,709,532 bp
  • T to A, chromosome 13 at 55,415,087 bp
  • G to T, chromosome 14 at 26,897,761 bp
  • T to C, chromosome 14 at 66,059,896 bp
  • C to T, chromosome 14 at 68,609,106 bp
  • A to T, chromosome 15 at 78,405,616 bp
  • A to G, chromosome 15 at 98,852,334 bp
  • CTCTTCTTCTTCTTC to CTCTTCTTCTTC, chromosome 16 at 10,790,701 bp
  • C to T, chromosome 16 at 20,594,611 bp
  • T to C, chromosome 16 at 44,219,063 bp
  • A to G, chromosome 17 at 21,882,003 bp
  • C to T, chromosome 17 at 23,994,618 bp
  • A to T, chromosome 18 at 12,195,048 bp
  • A to G, chromosome 18 at 37,519,105 bp
  • A to T, chromosome 18 at 75,605,644 bp
  • C to T, chromosome 19 at 17,329,359 bp
  • GCGAACG to GCG, chromosome 19 at 25,411,205 bp
  • G to A, chromosome X at 155,054,178 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7765 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045821-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.