Strain Name:
C57BL/6J-MtgxR7795Btlr/Mmmh
Stock Number:
045851-MU
Citation ID:
RRID:MMRRC_045851-MU
Other Names:
R7795 (G1)
Major Collection:

Strain Information

Rgs11
Name: regulator of G-protein signaling 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50782
HGNC: HGNC:9993
Homologene: 77719
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: 0610010D24Rik, Daple
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Pecam1
Name: platelet/endothelial cell adhesion molecule 1
Synonyms: PECAM-1, Cd31
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18613
HGNC: HGNC:8823
Homologene: 47925
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Exoc2
Name: exocyst complex component 2
Synonyms: Gm29675, 2410030I24Rik, Sec5l1, Sec5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66482
Homologene: 10122
Thoc1
Name: THO complex 1
Synonyms: NMP-84, 3110002N20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, Fam208a, MommeD6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Epcam
Name: epithelial cell adhesion molecule
Synonyms: EGP-2, EpCAM, Ly74, GA733-2, Egp314, panepithelial glycoprotein 314, Ep-CAM, EpCAM1, TROP1, CD326, Tacstd1, gp40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17075
VEGA: 17
Homologene: 1764
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Nbr1
Name: NBR1, autophagy cargo receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17966
HGNC: HGNC:6746
Homologene: 7438
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Mettl8
Name: methyltransferase 8, methylcytidine
Synonyms: TIP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228019
Homologene: 11706
Synj2bp
Name: synaptojanin 2 binding protein
Synonyms: activin receptor interacting protein 2, D12Wsu118e, ARIP2, OMP25
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24071
Homologene: 10161
Nkx6-1
Name: NK6 homeobox 1
Synonyms: NKX6A, Nkx6.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18096
HGNC: HGNC:7839
Homologene: 4495
Bmf
Name: BCL2 modifying factor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 171543
Homologene: 14130
Fcer2a
Name: Fc receptor, IgE, low affinity II, alpha polypeptide
Synonyms: low-affinity IgE receptor, Fce2, CD23, FC epsilon RII, Ly-42
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14128
HGNC: HGNC:3612
Homologene: 1517
Pcdh10
Name: protocadherin 10
Synonyms: OL-pc, Olpc, 6430521D13Rik, 6430703F07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18526
Homologene: 74967
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, Gm13190, 2700017I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: GA_x6K02T2QD9B-18838170-18837232, Olfr1341, MOR258-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258852
Homologene: 27281
Itga1
Name: integrin alpha 1
Synonyms: CD49A, Vla1, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Extl1
Name: exostosin-like glycosyltransferase 1
Synonyms: D430033M16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56219
HGNC: HGNC:3515
Homologene: 3277
Shc4
Name: SHC (Src homology 2 domain containing) family, member 4
Synonyms: 9930029B02Rik, LOC271849, 6230417E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271849
Homologene: 19567
Miip
Name: migration and invasion inhibitory protein
Synonyms: D4Wsu114e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 28010
Homologene: 15879
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Nlrp5
Name: NLR family, pyrin domain containing 5
Synonyms: Mater, Nalp5, Op1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23968
Homologene: 65105
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241158
Homologene: 9561
Or13a21
Name: olfactory receptor family 13 subfamily A member 21
Synonyms: MOR251-1, Olfr532, GA_x6K02T2PBJ9-42570051-42569122
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259028
Homologene: 133605
Ankle1
Name: ankyrin repeat and LEM domain containing 1
Synonyms: Ankrd41, 8430438L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234396
Homologene: 17562
Lrrc24
Name: leucine rich repeat containing 24
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 378937
Homologene: 86785
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252910
Homologene: 74352
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: D0H6S2654E, XAP-5-like, X5L
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Pccb
Name: propionyl Coenzyme A carboxylase, beta polypeptide
Synonyms: 1300012P06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66904
HGNC: HGNC:8654
Homologene: 447
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Or1j10
Name: olfactory receptor family 1 subfamily J member 10
Synonyms: GA_x6K02T2NLDC-33070879-33071799, MOR136-5, Olfr338
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258949
Homologene: 133647
Gal3st4
Name: galactose-3-O-sulfotransferase 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330217
Homologene: 11633
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: PLF-RP, Plfr, PRP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18814
Homologene: 7894
Vps45
Name: vacuolar protein sorting 45
Synonyms: mVps45
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22365
Homologene: 5250
Or3a1c
Name: olfactory receptor family 3 subfamily A member 1C
Synonyms: Olfr402, GA_x6K02T2P1NL-4307199-4308146, MOR255-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258703
HGNC: HGNC:8282
Homologene: 1915
Samd15
Name: sterile alpha motif domain containing 15
Synonyms: Gm263, LOC238333
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238333
Homologene: 52875
Mcidas
Name: multiciliate differentiation and DNA synthesis associated cell cycle protein
Synonyms: Gm6320, multicilin, Mcin, Idas, Mci
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 622408
VEGA: 13
Homologene: 83681
Defa27
Name: defensin, alpha, 27
Synonyms: Gm15299, ENSMUSG00000074438
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041811
Homologene: 113382
Igkv4-68
Name: immunoglobulin kappa variable 4-68
Synonyms: LOC232058, LOC384515
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384515
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 92,883,848 bp
  • G to T, chromosome 1 at 181,097,157 bp
  • G to A, chromosome 2 at 4,590,695 bp
  • A to G, chromosome 2 at 36,377,441 bp
  • T to C, chromosome 2 at 70,981,899 bp
  • A to G, chromosome 2 at 118,546,877 bp
  • T to A, chromosome 2 at 125,723,365 bp
  • T to C, chromosome 3 at 45,380,222 bp
  • A to G, chromosome 3 at 96,019,624 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • C to A, chromosome 4 at 118,709,658 bp
  • T to A, chromosome 4 at 134,364,679 bp
  • C to T, chromosome 4 at 147,862,918 bp
  • T to A, chromosome 5 at 32,944,103 bp
  • G to A, chromosome 5 at 92,919,649 bp
  • A to T, chromosome 5 at 101,663,762 bp
  • T to C, chromosome 5 at 138,270,838 bp
  • A to G, chromosome 6 at 69,304,912 bp
  • A to G, chromosome 7 at 10,748,209 bp
  • G to A, chromosome 7 at 23,418,794 bp
  • A to G, chromosome 7 at 140,419,114 bp
  • T to A, chromosome 8 at 3,682,910 bp
  • A to G, chromosome 8 at 21,316,338 bp
  • T to C, chromosome 8 at 71,408,693 bp
  • T to C, chromosome 9 at 100,999,263 bp
  • T to A, chromosome 10 at 58,483,907 bp
  • T to A, chromosome 11 at 74,156,018 bp
  • T to A, chromosome 11 at 101,569,328 bp
  • C to A, chromosome 11 at 106,695,832 bp
  • G to A, chromosome 12 at 81,502,148 bp
  • A to G, chromosome 12 at 87,200,732 bp
  • G to A, chromosome 12 at 100,923,311 bp
  • A to T, chromosome 13 at 27,709,280 bp
  • G to A, chromosome 13 at 30,876,773 bp
  • G to A, chromosome 13 at 34,747,101 bp
  • G to A, chromosome 13 at 112,998,987 bp
  • T to C, chromosome 13 at 115,012,236 bp
  • T to C, chromosome 14 at 27,481,383 bp
  • C to A, chromosome 14 at 35,321,685 bp
  • T to C, chromosome 14 at 60,691,842 bp
  • A to G, chromosome 15 at 76,718,048 bp
  • A to G, chromosome 17 at 26,207,578 bp
  • T to C, chromosome 17 at 87,643,555 bp
  • T to C, chromosome 18 at 9,986,300 bp
  • C to T, chromosome 18 at 19,966,231 bp
  • A to T, chromosome 18 at 86,461,073 bp
  • C to G, chromosome 19 at 4,749,012 bp
  • G to A, chromosome 19 at 39,876,219 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7795 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045851-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.