Strain Name:
C57BL/6J-MtgxR7856Btlr/Mmmh
Stock Number:
045909-MU
Citation ID:
RRID:MMRRC_045909-MU
Other Names:
R7856 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: T-type Cav3.2, alpha13.2, Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: 2500002E12Rik, A330076K04Rik, 1100001C18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Sh3p17, EHSH1, Intersectin-L, Ese1, Eh domain, SH3 domain regulator of endocytosis 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Gtse1
Name: G two S phase expressed protein 1
Synonyms: Gtse-1, B99
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24128
Homologene: 6927
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Ccdc34
Name: coiled-coil domain containing 34
Synonyms: 2810027O19Rik, 4930522P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68201
Homologene: 12245
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Rars1
Name: arginyl-tRNA synthetase 1
Synonyms: 2610011N19Rik, 2610037E21Rik, Rars
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104458
HGNC: HGNC:9870
Homologene: 68281
Ppp1r7
Name: protein phosphatase 1, regulatory subunit 7
Synonyms: 2310014J01Rik, SDS22
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66385
HGNC: HGNC:9295
Homologene: 2032
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: LOC382100, D030002L11Rik, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20850
Homologene: 20680
Yif1b
Name: Yip1 interacting factor homolog B (S. cerevisiae)
Synonyms: 9430029K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77254
Homologene: 60114
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Mx1
Name: MX dynamin-like GTPase 1
Synonyms: Mx-1, myxovirus (influenza) resistance 1 polypeptide, Mx
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17857
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226604
Homologene: 101040
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Slc4a9
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 9
Synonyms: D630024F24Rik, AE4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240215
VEGA: 18
Homologene: 23732
Or6c1b
Name: olfactory receptor family 6 subfamily C member 1B
Synonyms: Olfr786, GA_x6K02T2PULF-11116958-11117896, MOR111-5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258542
HGNC: HGNC:8355
Homologene: 133582
Or5m3
Name: olfactory receptor family 5 subfamily M member 3
Synonyms: MOR199-1, GA_x6K02T2Q125-47485813-47486745, Olfr1032
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258572
Homologene: 17299
Ces3b
Name: carboxylesterase 3B
Synonyms: Gm4738, ES31L
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13909
HGNC: HGNC:1865
Homologene: 84407
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: B230114P05Rik, ADAMTSL6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207596
Homologene: 49796
Ccdc63
Name: coiled-coil domain containing 63
Synonyms: 4921511C16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330188
Homologene: 45136
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245174
Homologene: 136215
Hook3
Name: hook microtubule tethering protein 3
Synonyms: 5830454D03Rik, E330005F07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320191
Homologene: 13022
Kti12
Name: KTI12 homolog, chromatin associated
Synonyms: 1110001A12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100087
Homologene: 6347
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239318
Homologene: 45574
Zfp850
Name: zinc finger protein 850
Synonyms: C130069I09Rik, Gm4636
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043772
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Dusp7
Name: dual specificity phosphatase 7
Synonyms: PYST2, MKP-X
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235584
HGNC: HGNC:3073
Homologene: 1468
Ttc34
Name: tetratricopeptide repeat domain 34
Synonyms: B230396O12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242800
Homologene: 130480
Tlx1
Name: T cell leukemia, homeobox 1
Synonyms: Hox-11, Hox11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21908
HGNC: HGNC:5056
Homologene: 4031
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,350,346 bp
  • A to T, chromosome 1 at 166,634,826 bp
  • T to A, chromosome 2 at 86,008,296 bp
  • T to A, chromosome 2 at 110,044,227 bp
  • T to G, chromosome 2 at 147,068,473 bp
  • T to C, chromosome 2 at 150,239,547 bp
  • T to C, chromosome 4 at 34,585,647 bp
  • A to C, chromosome 4 at 108,848,246 bp
  • G to T, chromosome 4 at 108,848,247 bp
  • T to C, chromosome 4 at 154,861,286 bp
  • T to A, chromosome 5 at 110,666,584 bp
  • A to G, chromosome 5 at 122,129,943 bp
  • A to T, chromosome 6 at 14,718,026 bp
  • A to G, chromosome 7 at 27,990,474 bp
  • A to G, chromosome 7 at 29,244,620 bp
  • T to C, chromosome 8 at 26,035,221 bp
  • G to A, chromosome 8 at 104,966,382 bp
  • A to G, chromosome 8 at 105,093,262 bp
  • A to T, chromosome 9 at 60,002,861 bp
  • C to A, chromosome 9 at 104,167,485 bp
  • C to A, chromosome 9 at 106,368,868 bp
  • A to G, chromosome 10 at 8,729,708 bp
  • T to C, chromosome 10 at 128,736,664 bp
  • A to G, chromosome 10 at 129,437,016 bp
  • A to G, chromosome 11 at 35,808,585 bp
  • T to C, chromosome 11 at 100,883,902 bp
  • A to T, chromosome 15 at 4,517,099 bp
  • C to T, chromosome 15 at 85,864,141 bp
  • A to G, chromosome 16 at 91,659,258 bp
  • T to A, chromosome 16 at 91,908,487 bp
  • A to G, chromosome 16 at 97,455,535 bp
  • T to C, chromosome 17 at 25,389,477 bp
  • C to T, chromosome 18 at 36,528,698 bp
  • T to C, chromosome 19 at 8,063,333 bp
  • C to T, chromosome 19 at 45,155,988 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7856 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045909-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.