Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7964Btlr/Mmmh
Stock Number:
046007-MU
Citation ID:
RRID:MMRRC_046007-MU
Other Names:
R7964 (G1)
Major Collection:

Strain Information

Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, bNOS, Nos-1, NO, 2310005C01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235469
Homologene: 17151
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: 5033402L14Rik, SNAT2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67760
VEGA: 15
Homologene: 23132
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: mBLVR1, Bolvr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 139,480,686 bp
  • A to G, chromosome 2 at 40,598,511 bp
  • T to C, chromosome 2 at 89,752,814 bp
  • A to G, chromosome 2 at 181,378,481 bp
  • A to G, chromosome 3 at 116,687,335 bp
  • T to C, chromosome 3 at 146,068,776 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to G, chromosome 4 at 128,523,510 bp
  • T to A, chromosome 4 at 131,891,233 bp
  • T to C, chromosome 4 at 143,397,240 bp
  • A to G, chromosome 5 at 100,698,911 bp
  • T to A, chromosome 5 at 117,900,542 bp
  • G to A, chromosome 6 at 42,629,706 bp
  • T to C, chromosome 6 at 118,523,199 bp
  • C to T, chromosome 6 at 139,882,060 bp
  • A to G, chromosome 7 at 4,010,804 bp
  • A to C, chromosome 7 at 5,328,528 bp
  • A to T, chromosome 7 at 18,565,199 bp
  • A to G, chromosome 7 at 18,647,211 bp
  • T to C, chromosome 7 at 114,846,473 bp
  • A to C, chromosome 7 at 128,140,418 bp
  • G to T, chromosome 7 at 131,298,234 bp
  • T to C, chromosome 8 at 22,625,352 bp
  • T to A, chromosome 8 at 40,755,539 bp
  • G to T, chromosome 8 at 40,796,907 bp
  • A to G, chromosome 8 at 46,170,200 bp
  • T to A, chromosome 8 at 47,526,944 bp
  • T to A, chromosome 9 at 41,991,401 bp
  • A to G, chromosome 9 at 53,931,576 bp
  • T to A, chromosome 9 at 72,322,458 bp
  • A to G, chromosome 10 at 27,223,981 bp
  • A to G, chromosome 10 at 80,068,351 bp
  • C to A, chromosome 10 at 80,730,057 bp
  • T to C, chromosome 10 at 115,452,174 bp
  • C to A, chromosome 10 at 127,575,044 bp
  • A to T, chromosome 11 at 9,316,146 bp
  • T to C, chromosome 11 at 24,163,353 bp
  • G to T, chromosome 11 at 53,464,322 bp
  • A to G, chromosome 11 at 53,470,174 bp
  • C to A, chromosome 11 at 68,533,739 bp
  • T to C, chromosome 11 at 69,126,536 bp
  • A to G, chromosome 12 at 13,356,895 bp
  • A to G, chromosome 12 at 28,470,319 bp
  • C to A, chromosome 12 at 85,339,013 bp
  • T to C, chromosome 12 at 111,540,174 bp
  • G to A, chromosome 15 at 96,692,572 bp
  • T to C, chromosome 16 at 48,951,905 bp
  • T to A, chromosome 17 at 24,402,436 bp
  • C to A, chromosome 18 at 37,444,818 bp
  • C to T, chromosome 19 at 20,700,007 bp
  • C to T, chromosome 19 at 20,716,042 bp
  • T to C, chromosome 19 at 21,798,430 bp
  • A to T, chromosome Y at 1,316,914 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7964 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046007-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.