Strain Name:
C57BL/6J-MtgxR7964Btlr/Mmmh
Stock Number:
046007-MU
Citation ID:
RRID:MMRRC_046007-MU
Other Names:
R7964 (G1)
Major Collection:

Strain Information

Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: Nos-1, nNOS, 2310005C01Rik, bNOS, NO
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235469
Homologene: 17151
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: SNAT2, 5033402L14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67760
VEGA: 15
Homologene: 23132
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: Bolvr, mBLVR1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: 2810011H21Rik, D12Ertd549e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 2A-HUB, 6430549P11Rik, 2310047C04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224170
Homologene: 8771
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: Sfrs4, SRp75, 5730499P16Rik, MNCb-2616
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57317
Homologene: 25624
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: 2900010L19Rik, mSorLA, LR11, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Cfap97
Name: cilia and flagella associated protein 97
Synonyms: 4933411K20Rik, 1110068E21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66756
Homologene: 12026
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232339
Homologene: 45968
Hpse
Name: heparanase
Synonyms: Hpa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15442
HGNC: HGNC:5164
Homologene: 68528
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: Abc3, ABC-C, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Insc
Name: INSC spindle orientation adaptor protein
Synonyms: Inscuteable, 3830422K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233752
Homologene: 78662
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dnai3
Name: dynein axonemal intermediate chain 3
Synonyms: 4931433A13Rik, IC140, Wdr63, Ida7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242253
Homologene: 44922
Pramel1
Name: PRAME like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83491
Homologene: 87078
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Elmod1
Name: ELMO/CED-12 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270162
VEGA: 9
Homologene: 10280
Or4a80
Name: olfactory receptor family 4 subfamily A member 80
Synonyms: Olfr1253-ps1, Olfr1559-ps1, GA_x6K02T2Q125-51193814-51192857, MOR231-19P, Olfr1253, MOR231-19P, MOR231-18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258370
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nbs1, Nalp2, PYPAF2, E330007A02Rik, Pan1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p87PIKAP, p84 Pikap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104709
Homologene: 46215
Pcdhb13
Name: protocadherin beta 13
Synonyms: PcdhbM, Pcdbh6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Shroom1
Name: shroom family member 1
Synonyms: Shrm1, 1300007L22Rik, Apx
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71774
Homologene: 12411
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26358
HGNC: HGNC:402
Homologene: 137245
Psg21
Name: pregnancy-specific beta-1-glycoprotein 21
Synonyms: cea8, 1600026N13Rik, 1600025N01Rik, 1600019C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72242
Homologene: 110989
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 107868
Homologene: 68408
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CR4, CD11C (p150) alpha polypeptide
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: D7Bwg0421e, mLair-1, Lair-1, 5133400O11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52855
Homologene: 48097
Psg27
Name: pregnancy-specific beta-1-glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545925
Homologene: 110989
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Dkk4
Name: dickkopf WNT signaling pathway inhibitor 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234130
HGNC: HGNC:2894
Homologene: 8680
Zgpat
Name: zinc finger, CCCH-type with G patch domain
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229007
Homologene: 41874
Bcl11a
Name: BCL11 transcription factor A
Synonyms: D930021L15Rik, mouse myeloid leukemia gene, COUP-TF interacting protein 1, CTIP1, 2810047E18Rik, Evi9, Evi9a, Evi9b, Evi9c
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14025
Homologene: 11284
Dcdc2c
Name: doublecortin domain containing 2C
Synonyms: 1110015M06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68511
Homologene: 131934
Slc35a3
Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
Synonyms: 2310050P13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229782
Homologene: 40826
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23801
Homologene: 8013
Gm9837
Name: predicted gene 9837
Type: Gene
Species: Mouse
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 139,480,686 bp
  • A to G, chromosome 2 at 40,598,511 bp
  • T to C, chromosome 2 at 89,752,814 bp
  • A to G, chromosome 2 at 181,378,481 bp
  • A to G, chromosome 3 at 116,687,335 bp
  • T to C, chromosome 3 at 146,068,776 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to G, chromosome 4 at 128,523,510 bp
  • T to A, chromosome 4 at 131,891,233 bp
  • T to C, chromosome 4 at 143,397,240 bp
  • A to G, chromosome 5 at 100,698,911 bp
  • T to A, chromosome 5 at 117,900,542 bp
  • G to A, chromosome 6 at 42,629,706 bp
  • T to C, chromosome 6 at 118,523,199 bp
  • C to T, chromosome 6 at 139,882,060 bp
  • A to G, chromosome 7 at 4,010,804 bp
  • A to C, chromosome 7 at 5,328,528 bp
  • A to T, chromosome 7 at 18,565,199 bp
  • A to G, chromosome 7 at 18,647,211 bp
  • T to C, chromosome 7 at 114,846,473 bp
  • A to C, chromosome 7 at 128,140,418 bp
  • G to T, chromosome 7 at 131,298,234 bp
  • T to C, chromosome 8 at 22,625,352 bp
  • T to A, chromosome 8 at 40,755,539 bp
  • G to T, chromosome 8 at 40,796,907 bp
  • A to G, chromosome 8 at 46,170,200 bp
  • T to A, chromosome 8 at 47,526,944 bp
  • T to A, chromosome 9 at 41,991,401 bp
  • A to G, chromosome 9 at 53,931,576 bp
  • T to A, chromosome 9 at 72,322,458 bp
  • A to G, chromosome 10 at 27,223,981 bp
  • A to G, chromosome 10 at 80,068,351 bp
  • C to A, chromosome 10 at 80,730,057 bp
  • T to C, chromosome 10 at 115,452,174 bp
  • C to A, chromosome 10 at 127,575,044 bp
  • A to T, chromosome 11 at 9,316,146 bp
  • T to C, chromosome 11 at 24,163,353 bp
  • G to T, chromosome 11 at 53,464,322 bp
  • A to G, chromosome 11 at 53,470,174 bp
  • C to A, chromosome 11 at 68,533,739 bp
  • T to C, chromosome 11 at 69,126,536 bp
  • A to G, chromosome 12 at 13,356,895 bp
  • A to G, chromosome 12 at 28,470,319 bp
  • C to A, chromosome 12 at 85,339,013 bp
  • T to C, chromosome 12 at 111,540,174 bp
  • G to A, chromosome 15 at 96,692,572 bp
  • T to C, chromosome 16 at 48,951,905 bp
  • T to A, chromosome 17 at 24,402,436 bp
  • C to A, chromosome 18 at 37,444,818 bp
  • C to T, chromosome 19 at 20,700,007 bp
  • C to T, chromosome 19 at 20,716,042 bp
  • T to C, chromosome 19 at 21,798,430 bp
  • A to T, chromosome Y at 1,316,914 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7964 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046007-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.