Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7970Btlr/Mmmh
Stock Number:
046013-MU
Citation ID:
RRID:MMRRC_046013-MU
Other Names:
R7970 (G1)
Major Collection:

Strain Information

Evl
Name: Ena-vasodilator stimulated phosphoprotein
Synonyms: b2b2600Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14026
VEGA: 12
Homologene: 56752
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Arrdc4
Name: arrestin domain containing 4
Synonyms: 2410003C09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66412
Homologene: 41636
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
B3gnt2
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms: B3Galt6, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53625
Homologene: 4797
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,951,795 bp
  • G to T, chromosome 1 at 34,182,747 bp
  • T to C, chromosome 1 at 40,726,214 bp
  • T to C, chromosome 1 at 63,304,171 bp
  • T to A, chromosome 1 at 106,173,285 bp
  • T to A, chromosome 1 at 126,025,021 bp
  • A to G, chromosome 1 at 134,993,985 bp
  • T to C, chromosome 2 at 25,273,287 bp
  • A to T, chromosome 2 at 66,675,829 bp
  • T to C, chromosome 2 at 70,752,300 bp
  • A to T, chromosome 2 at 88,005,825 bp
  • A to T, chromosome 2 at 166,051,357 bp
  • T to C, chromosome 3 at 83,837,894 bp
  • A to G, chromosome 4 at 49,449,266 bp
  • A to T, chromosome 4 at 56,771,466 bp
  • G to A, chromosome 4 at 108,486,454 bp
  • T to A, chromosome 5 at 13,599,407 bp
  • T to C, chromosome 5 at 14,714,478 bp
  • A to G, chromosome 5 at 90,367,709 bp
  • AGG to AG, chromosome 5 at 114,015,209 bp
  • A to G, chromosome 5 at 114,263,007 bp
  • T to A, chromosome 5 at 151,063,261 bp
  • G to T, chromosome 6 at 29,447,526 bp
  • C to T, chromosome 6 at 59,353,165 bp
  • A to T, chromosome 6 at 91,786,532 bp
  • T to A, chromosome 6 at 115,617,308 bp
  • G to A, chromosome 7 at 24,916,881 bp
  • G to A, chromosome 7 at 68,741,072 bp
  • C to A, chromosome 7 at 105,091,349 bp
  • A to G, chromosome 7 at 135,678,319 bp
  • A to G, chromosome 8 at 34,855,926 bp
  • A to G, chromosome 8 at 35,815,647 bp
  • T to C, chromosome 8 at 63,345,715 bp
  • G to A, chromosome 8 at 105,951,605 bp
  • A to C, chromosome 8 at 110,309,091 bp
  • A to G, chromosome 9 at 65,839,016 bp
  • C to T, chromosome 9 at 102,723,769 bp
  • T to C, chromosome 10 at 53,699,325 bp
  • T to C, chromosome 11 at 22,836,255 bp
  • T to G, chromosome 11 at 32,722,101 bp
  • C to T, chromosome 11 at 74,842,210 bp
  • A to T, chromosome 11 at 102,437,866 bp
  • T to C, chromosome 11 at 116,690,343 bp
  • A to T, chromosome 12 at 72,308,874 bp
  • C to T, chromosome 12 at 108,681,524 bp
  • T to C, chromosome 12 at 112,964,200 bp
  • A to T, chromosome 13 at 49,609,266 bp
  • A to G, chromosome 13 at 63,033,160 bp
  • A to G, chromosome 14 at 54,920,503 bp
  • CAGCTGGAGGAGC to CAGC, chromosome 15 at 78,436,913 bp
  • T to C, chromosome 15 at 99,933,586 bp
  • G to A, chromosome 16 at 23,357,835 bp
  • T to A, chromosome 16 at 94,457,364 bp
  • T to C, chromosome 17 at 23,311,212 bp
  • G to A, chromosome 17 at 28,550,728 bp
  • A to G, chromosome 17 at 34,150,598 bp
  • A to G, chromosome 17 at 56,849,728 bp
  • T to A, chromosome 19 at 13,027,694 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7970 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046013-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.