Strain Name:
C57BL/6J-MtgxR8114Btlr/Mmmh
Stock Number:
067543-MU
Citation ID:
RRID:MMRRC_067543-MU
Other Names:
R8114 (G1)
Major Collection:

Strain Information

Snx17
Name: sorting nexin 17
Synonyms: 5830447M19Rik, b2b1625.1Clo, D5Ertd260e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 266781
Homologene: 8838
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245945
Homologene: 36932
Gdi2
Name: GDP dissociation inhibitor 2
Synonyms: GDIB, GDI-B, GDI beta, Gdi3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14569
VEGA: 13
HGNC: HGNC:4227
Homologene: 37488
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: A630020C16Rik, 4930502N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Arih1
Name: ariadne RBR E3 ubiquitin protein ligase 1
Synonyms: UIP77
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23806
HGNC: HGNC:689
Homologene: 111871
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Tmem39a
Name: transmembrane protein 39a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67846
Homologene: 9985
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Platr25
Name: pluripotency associated transcript 25
Synonyms: 6720490N10Rik, Gm5665
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435366
Surf6
Name: surfeit gene 6
Synonyms: Surf-6, D2Wsu129e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20935
Homologene: 133981
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Adam12
Name: ADAM metallopeptidase domain 12
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Cd274
Name: CD274 antigen
Synonyms: PD-L1, B7-H1, Pdcd1lg1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 60533
Homologene: 8560
Tiprl
Name: TIP41, TOR signalling pathway regulator-like (S. cerevisiae)
Synonyms: 1810011K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226591
Homologene: 7140
Ldah
Name: lipid droplet associated hydrolase
Synonyms: 1110057K04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68832
VEGA: 12
Homologene: 41453
Cul2
Name: cullin 2
Synonyms: 1300003D18Rik, 4932411N15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71745
HGNC: HGNC:2552
Homologene: 2662
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, A330015D16Rik, 4930473A06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320226
Homologene: 27942
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, A430109M19Rik, ZFYVE2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Ythdc2
Name: YTH domain containing 2
Synonyms: 3010002F02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240255
Homologene: 11265
Trpc7
Name: transient receptor potential cation channel, subfamily C, member 7
Synonyms: TRP7, Trrp8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26946
Homologene: 22689
Tns2
Name: tensin 2
Synonyms: nep, Tenc1, nph
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1565Clo, b2b3491Clo, Mdnah5, b2b1154Clo, b2b1537Clo, Dnahc5, b2b1134Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Sim2
Name: single-minded family bHLH transcription factor 2
Synonyms: bHLHe15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20465
VEGA: 16
Homologene: 3716
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Oas1e
Name: 2'-5' oligoadenylate synthetase 1E
Synonyms: 2'-5' oligoadenylate synthetase-like 7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231699
HGNC: HGNC:8086
Homologene: 110815
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319800
Homologene: 77136
Slc34a2
Name: solute carrier family 34 (sodium phosphate), member 2
Synonyms: D5Ertd227e, type IIb Na/Picotransporter, Npt2b, NaPi-2b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20531
Homologene: 2297
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20419
Homologene: 32123
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Or8k53
Name: olfactory receptor family 8 subfamily K member 53
Synonyms: Olfr1055, GA_x6K02T2Q125-47819205-47818258, MOR186-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259023
Homologene: 131140
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: C230094A16Rik, 2900083P10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Cdcp2
Name: CUB domain containing protein 2
Synonyms: D030010E02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242603
Homologene: 138406
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Zfp959
Name: zinc finger protein 959
Synonyms: BC011426
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224893
Homologene: 138295
Daglb
Name: diacylglycerol lipase, beta
Synonyms: E330036I19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231871
Homologene: 34715
Serpinb3c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 3C
Synonyms: ovalbumin, 1110001H02Rik, Scca2, 1110013A16Rik, Serpinb4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381286
Homologene: 131278
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: Drapc1, EIG180
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Ccdc63
Name: coiled-coil domain containing 63
Synonyms: 4921511C16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330188
Homologene: 45136
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mel1b, Mt2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Odr4
Name: odr4 GPCR localization factor homolog
Synonyms: BC003331, 1810053E15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226499
Homologene: 41202
Or10al6
Name: olfactory receptor family 10 subfamily AL member 6
Synonyms: MOR263-10, GA_x6K02T2PSCP-2230932-2231897, Olfr122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258285
Homologene: 122777
Trdn
Name: triadin
Synonyms: triadin-2, triadin 2, triadin-3, triadin 3, triadin 1, 2310045H21Rik, triadin-1, EG432451
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Ccdc121rt3
Name: coiled-coil domain containing 121, retrogene 3
Synonyms: Gm6583
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625424
Homologene: 116059
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Or10v9
Name: olfactory receptor family 10 subfamily V member 9
Synonyms: GA_x6K02T2RE5P-2207258-2206302, Olfr1418, MOR266-5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258227
Homologene: 79372
Fgl1
Name: fibrinogen-like protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234199
HGNC: HGNC:3695
Homologene: 37927
A630010A05Rik
Name: RIKEN cDNA A630010A05 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545280
Cfap298
Name: cilia and flagella associate protien 298
Synonyms: 1110004E09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68001
HGNC: HGNC:1301
Homologene: 10941
Klhl3
Name: kelch-like 3
Synonyms: EG627648, 7530408C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 107,276,304 bp
  • A to T, chromosome 1 at 150,388,557 bp
  • A to G, chromosome 1 at 165,228,422 bp
  • G to A, chromosome 2 at 26,892,368 bp
  • A to T, chromosome 2 at 52,325,722 bp
  • A to T, chromosome 2 at 86,347,186 bp
  • G to A, chromosome 2 at 120,704,430 bp
  • A to G, chromosome 3 at 116,881,776 bp
  • A to G, chromosome 4 at 83,696,300 bp
  • A to T, chromosome 4 at 107,105,358 bp
  • A to T, chromosome 5 at 31,197,702 bp
  • G to A, chromosome 5 at 53,068,359 bp
  • T to C, chromosome 5 at 66,026,853 bp
  • C to A, chromosome 5 at 112,355,697 bp
  • T to C, chromosome 5 at 120,786,643 bp
  • G to T, chromosome 5 at 122,113,181 bp
  • A to G, chromosome 5 at 143,478,463 bp
  • A to G, chromosome 6 at 121,413,499 bp
  • A to T, chromosome 7 at 41,861,968 bp
  • A to T, chromosome 7 at 85,155,889 bp
  • A to G, chromosome 7 at 97,516,525 bp
  • A to G, chromosome 7 at 112,093,187 bp
  • T to C, chromosome 7 at 133,967,888 bp
  • T to A, chromosome 8 at 4,767,930 bp
  • A to G, chromosome 8 at 41,191,583 bp
  • A to T, chromosome 8 at 45,943,103 bp
  • A to G, chromosome 9 at 15,874,267 bp
  • A to G, chromosome 9 at 59,396,553 bp
  • T to C, chromosome 10 at 33,083,628 bp
  • T to C, chromosome 10 at 80,009,040 bp
  • G to T, chromosome 10 at 95,994,989 bp
  • C to T, chromosome 11 at 29,754,910 bp
  • A to G, chromosome 12 at 8,284,039 bp
  • T to C, chromosome 12 at 112,774,729 bp
  • T to C, chromosome 13 at 3,548,906 bp
  • T to C, chromosome 13 at 56,804,598 bp
  • C to T, chromosome 13 at 58,013,863 bp
  • T to C, chromosome 13 at 62,673,924 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • A to T, chromosome 15 at 28,239,976 bp
  • G to C, chromosome 15 at 102,111,390 bp
  • G to T, chromosome 16 at 14,589,227 bp
  • A to G, chromosome 16 at 37,042,215 bp
  • C to A, chromosome 16 at 38,590,996 bp
  • T to G, chromosome 16 at 38,590,997 bp
  • T to C, chromosome 16 at 90,934,657 bp
  • T to C, chromosome 16 at 94,122,644 bp
  • T to C, chromosome 17 at 37,771,989 bp
  • T to C, chromosome 17 at 50,687,787 bp
  • A to G, chromosome 17 at 55,898,496 bp
  • A to T, chromosome 18 at 3,426,164 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • G to T, chromosome 18 at 31,965,624 bp
  • A to G, chromosome 18 at 44,877,740 bp
  • A to G, chromosome 18 at 62,950,056 bp
  • A to G, chromosome 18 at 78,030,150 bp
  • A to T, chromosome 19 at 8,404,540 bp
  • G to A, chromosome 19 at 11,855,102 bp
  • T to C, chromosome 19 at 29,384,128 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8114 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067543-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.