Strain Name:
C57BL/6J-MtgxR8142Btlr/Mmmh
Stock Number:
067570-MU
Citation ID:
RRID:MMRRC_067570-MU
Other Names:
R8142 (G1)
Major Collection:

Strain Information

Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Listerin, Zfp294, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Stk38l
Name: serine/threonine kinase 38 like
Synonyms: 4930473A22Rik, Ndr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232533
Homologene: 56299
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: Psa, MP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Dusp5
Name: dual specificity phosphatase 5
Synonyms: LOC240672
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240672
HGNC: HGNC:3071
Homologene: 3256
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Bmpr2
Name: bone morphogenetic protein receptor type 2
Synonyms: BMPR-II, BMPRII, BMP-2, 2610024H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12168
HGNC: HGNC:1078
Homologene: 929
Zbtb21
Name: zinc finger and BTB domain containing 21
Synonyms: B430213I24Rik, 5430437K12Rik, Zfp295, Znf295
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 114565
VEGA: 16
Homologene: 10799
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, leptin receptor gene-related protein, LEPROT, Obr, obl, Modb1, obese-like
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Pon2
Name: paraoxonase 2
Synonyms: 6330405I24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330260
HGNC: HGNC:9205
Homologene: 385
Tmem201
Name: transmembrane protein 201
Synonyms: D4Ertd429e, Samp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230917
Homologene: 35319
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27215
Homologene: 8443
Stau2
Name: staufen double-stranded RNA binding protein 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29819
Homologene: 8666
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Uncx
Name: UNC homeobox
Synonyms: Uncx4.1, Chx4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22255
Homologene: 56598
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Marveld2
Name: MARVEL (membrane-associating) domain containing 2
Synonyms: Tric-c, Tric-a, Tricellulin, Tric-b, Tric, Mrvldc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218518
VEGA: 13
Homologene: 27037
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Vrtn
Name: vertebrae development associated
Synonyms: 7420416P09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432677
VEGA: 12
Homologene: 41236
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55963
Homologene: 20655
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, N-CAD, Ncad
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Ccno
Name: cyclin O
Synonyms: Ccnu, Ung2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218630
VEGA: 13
Homologene: 50171
Serpinb6c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6c
Synonyms: Spi3C, ovalbumin, SPIC
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97848
HGNC: HGNC:8950
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81840
Homologene: 56899
Marchf1
Name: membrane associated ring-CH-type finger 1
Synonyms: 2900024D24Rik, March1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72925
Homologene: 113749
Zbtb34
Name: zinc finger and BTB domain containing 34
Synonyms: LOC241311
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241311
Homologene: 19382
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Cyp2f2
Name: cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms: Cyp2f
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13107
Homologene: 73898
Atp6v1e2
Name: ATPase, H+ transporting, lysosomal V1 subunit E2
Synonyms: Atp6e1, lysosomal 31kDa, 4930500C14Rik, E1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74915
VEGA: 17
Homologene: 41770
Dtd2
Name: D-tyrosyl-tRNA deacylase 2
Synonyms: 4930578F06Rik, 6530401N04Rik, B830049N13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328092
Homologene: 12634
Nherf4
Name: NHERF family PDZ scaffold protein 4
Synonyms: Pdzk2, sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2, Pdzd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Fitm1
Name: fat storage-inducing transmembrane protein 1
Synonyms: 1110028A07Rik, Cg10671, Fit1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68680
Homologene: 41695
Mypop
Name: Myb-related transcription factor, partner of profilin
Synonyms: P42pop, Myodysa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232934
Homologene: 17083
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Epha10
Name: Eph receptor A10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230735
Homologene: 67804
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp1, Lsh, Ity1, Ity, Nramp, host resistance locus Bcg/Ity/Lsh, Bcg, ity
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18173
Homologene: 73884
Ifit3
Name: interferon-induced protein with tetratricopeptide repeats 3
Synonyms: Ifi49
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15959
HGNC: HGNC:5411
Homologene: 1189
Rnase13
Name: ribonuclease, RNase A family, 13 (non-active)
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 497071
VEGA: 14
Homologene: 79130
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: EG639426, AU024163, 4921506M07Rik, Gm9813, LOC217602
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Or6c63-ps1
Name: olfactory receptor family 6 subfamily C member 63, pseudogene 1
Synonyms: MOR115-2, GA_x6K02T2PULF-10749079-10748573, Olfr766-ps1, Olfr766, EG546487, EG544748
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 546487
Homologene: 67771
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 16,460,351 bp
  • T to C, chromosome 1 at 59,870,306 bp
  • T to C, chromosome 1 at 74,385,259 bp
  • G to C, chromosome 1 at 87,540,741 bp
  • T to C, chromosome 1 at 91,421,547 bp
  • G to T, chromosome 2 at 33,412,481 bp
  • A to T, chromosome 3 at 38,891,203 bp
  • G to T, chromosome 3 at 93,215,475 bp
  • C to A, chromosome 4 at 101,765,419 bp
  • T to A, chromosome 4 at 104,678,724 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • A to G, chromosome 4 at 124,885,846 bp
  • T to C, chromosome 4 at 149,718,657 bp
  • T to C, chromosome 5 at 36,062,614 bp
  • A to G, chromosome 5 at 124,408,545 bp
  • A to G, chromosome 5 at 139,546,900 bp
  • A to T, chromosome 6 at 5,266,239 bp
  • A to G, chromosome 6 at 146,758,572 bp
  • A to G, chromosome 7 at 3,736,843 bp
  • A to G, chromosome 7 at 19,001,126 bp
  • G to A, chromosome 7 at 27,129,253 bp
  • T to C, chromosome 7 at 120,060,966 bp
  • T to C, chromosome 8 at 66,456,126 bp
  • A to G, chromosome 9 at 44,250,781 bp
  • T to C, chromosome 9 at 44,354,555 bp
  • T to G, chromosome 9 at 74,139,667 bp
  • A to G, chromosome 9 at 118,049,407 bp
  • C to T, chromosome 10 at 59,049,383 bp
  • T to A, chromosome 10 at 129,064,650 bp
  • A to G, chromosome 11 at 20,307,890 bp
  • G to T, chromosome 11 at 97,218,572 bp
  • T to A, chromosome 12 at 51,999,810 bp
  • A to T, chromosome 12 at 57,697,472 bp
  • T to C, chromosome 12 at 84,650,621 bp
  • T to A, chromosome 13 at 33,880,113 bp
  • T to C, chromosome 13 at 100,600,940 bp
  • T to G, chromosome 13 at 112,988,955 bp
  • A to G, chromosome 14 at 51,414,107 bp
  • A to G, chromosome 14 at 51,922,436 bp
  • G to A, chromosome 14 at 55,073,438 bp
  • T to C, chromosome 14 at 55,575,790 bp
  • G to T, chromosome 15 at 28,384,373 bp
  • G to A, chromosome 15 at 44,514,931 bp
  • A to C, chromosome 16 at 87,381,641 bp
  • T to C, chromosome 16 at 97,951,475 bp
  • A to T, chromosome 17 at 86,944,655 bp
  • A to C, chromosome 18 at 16,601,734 bp
  • A to G, chromosome 18 at 37,721,113 bp
  • G to T, chromosome 19 at 34,587,501 bp
  • T to C, chromosome 19 at 53,537,481 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8142 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067570-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.