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Strain Name:
C57BL/6J-MtgxR8142Btlr/Mmmh
Stock Number:
067570-MU
Citation ID:
RRID:MMRRC_067570-MU
Other Names:
R8142 (G1)
Major Collection:

Strain Information

Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Stk38l
Name: serine/threonine kinase 38 like
Synonyms: 4930473A22Rik, Ndr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232533
Homologene: 56299
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Dusp5
Name: dual specificity phosphatase 5
Synonyms: LOC240672
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240672
HGNC: HGNC:3071
Homologene: 3256
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Bmpr2
Name: bone morphogenetic protein receptor type 2
Synonyms: BMPR-II, BMP-2, 2610024H22Rik, BMPRII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12168
HGNC: HGNC:1078
Homologene: 929
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 16,460,351 bp
  • T to C, chromosome 1 at 59,870,306 bp
  • T to C, chromosome 1 at 74,385,259 bp
  • G to C, chromosome 1 at 87,540,741 bp
  • T to C, chromosome 1 at 91,421,547 bp
  • G to T, chromosome 2 at 33,412,481 bp
  • A to T, chromosome 3 at 38,891,203 bp
  • G to T, chromosome 3 at 93,215,475 bp
  • C to A, chromosome 4 at 101,765,419 bp
  • T to A, chromosome 4 at 104,678,724 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • A to G, chromosome 4 at 124,885,846 bp
  • T to C, chromosome 4 at 149,718,657 bp
  • T to C, chromosome 5 at 36,062,614 bp
  • A to G, chromosome 5 at 124,408,545 bp
  • A to G, chromosome 5 at 139,546,900 bp
  • A to T, chromosome 6 at 5,266,239 bp
  • A to G, chromosome 6 at 146,758,572 bp
  • A to G, chromosome 7 at 3,736,843 bp
  • A to G, chromosome 7 at 19,001,126 bp
  • G to A, chromosome 7 at 27,129,253 bp
  • T to C, chromosome 7 at 120,060,966 bp
  • T to C, chromosome 8 at 66,456,126 bp
  • A to G, chromosome 9 at 44,250,781 bp
  • T to C, chromosome 9 at 44,354,555 bp
  • T to G, chromosome 9 at 74,139,667 bp
  • A to G, chromosome 9 at 118,049,407 bp
  • C to T, chromosome 10 at 59,049,383 bp
  • T to A, chromosome 10 at 129,064,650 bp
  • A to G, chromosome 11 at 20,307,890 bp
  • G to T, chromosome 11 at 97,218,572 bp
  • T to A, chromosome 12 at 51,999,810 bp
  • A to T, chromosome 12 at 57,697,472 bp
  • T to C, chromosome 12 at 84,650,621 bp
  • T to A, chromosome 13 at 33,880,113 bp
  • T to C, chromosome 13 at 100,600,940 bp
  • T to G, chromosome 13 at 112,988,955 bp
  • A to G, chromosome 14 at 51,414,107 bp
  • A to G, chromosome 14 at 51,922,436 bp
  • G to A, chromosome 14 at 55,073,438 bp
  • T to C, chromosome 14 at 55,575,790 bp
  • G to T, chromosome 15 at 28,384,373 bp
  • G to A, chromosome 15 at 44,514,931 bp
  • A to C, chromosome 16 at 87,381,641 bp
  • T to C, chromosome 16 at 97,951,475 bp
  • A to T, chromosome 17 at 86,944,655 bp
  • A to C, chromosome 18 at 16,601,734 bp
  • A to G, chromosome 18 at 37,721,113 bp
  • G to T, chromosome 19 at 34,587,501 bp
  • T to C, chromosome 19 at 53,537,481 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8142 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067570-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.