Strain Name:
C57BL/6J-MtgxR8147Btlr/Mmmh
Stock Number:
067575-MU
Citation ID:
RRID:MMRRC_067575-MU
Other Names:
R8147 (G1)
Major Collection:

Strain Information

Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67800
Homologene: 23580
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: BB001228, 2510010B09Rik, Cxxc6, D10Ertd17e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Ints6
Name: integrator complex subunit 6
Synonyms: DICE1, 2900075H24Rik, Ddx26, Notch2l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, Txnl2, PICOT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, 5730544L10Rik, C430013M08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228545
Homologene: 13302
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Mia3
Name: MIA SH3 domain ER export factor 3
Synonyms: B230399H06Rik, Tango, LOC385255, 9130229H14Rik, A930039G15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 338366
Homologene: 85165
Pafah1b2
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
Synonyms: PAF-AH 30, mus[b], Pafahb, PAF-AH alpha2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18475
VEGA: 9
HGNC: HGNC:8575
Homologene: 1932
Nus1
Name: NUS1 dehydrodolichyl diphosphate synthase subunit
Synonyms: 1600027K07Rik, D10Ertd438e, NgBR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52014
Homologene: 12719
Cert1
Name: ceramide transporter 1
Synonyms: GPBP, Cert, Col4a3bp, 9230101K08Rik, 2810404O15Rik, ceramide transport protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68018
VEGA: 13
HGNC: HGNC:2205
Homologene: 4173
Sympk
Name: symplekin
Synonyms: 4632415H16Rik, 1500016F02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68188
Homologene: 37969
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 9530009M10Rik, 1810037O03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Zfp808
Name: zinc finger protein 808
Synonyms: Gm7036
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 630579
Homologene: 134631
Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms: p52, NF kappaB2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18034
VEGA: 19
HGNC: HGNC:7795
Homologene: 1873
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Trim55
Name: tripartite motif-containing 55
Synonyms: D830041C10Rik, Murf2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381485
Homologene: 13205
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: Anubl1, 2810002D23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67492
VEGA: 6
Homologene: 18373
Aldh9a1
Name: aldehyde dehydrogenase 9, subfamily A1
Synonyms: TMABA-DH, ESTM40
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56752
HGNC: HGNC:412
Homologene: 55483
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Pold2
Name: polymerase (DNA directed), delta 2, regulatory subunit
Synonyms: 50kDa, po1D2, p50
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18972
HGNC: HGNC:9176
Homologene: 4538
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Prl8a8
Name: prolactin family 8, subfamily a, member 81
Synonyms: 1600032B14Rik, Prlpc3, PLP-Cgamma
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74188
Homologene: 137338
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76365
Homologene: 11384
Trim12c
Name: tripartite motif-containing 12C
Synonyms: Trim12-2, 9230105E10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319236
Homologene: 75345
Taar5
Name: trace amine-associated receptor 5
Synonyms: LOC215854
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215854
Homologene: 20850
Or2y14
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: Olfr1384, GA_x6K02T2QP88-5922712-5921756, MOR256-23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258464
Homologene: 74259
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4, NGL-3, Ngl3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272381
Homologene: 45681
Slc28a2
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Synonyms: 2010208B10Rik, CNT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269346
Homologene: 20891
Stat5b
Name: signal transducer and activator of transcription 5B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20851
Homologene: 55718
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Or4c31
Name: olfactory receptor family 4 subfamily C member 31
Synonyms: GA_x6K02T2Q125-49948903-49949814, Olfr1183, MOR230-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258522
Homologene: 128125
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93838
Homologene: 14143
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Senp5
Name: SUMO/sentrin specific peptidase 5
Synonyms: 6230429P13Rik, A730063F07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320213
Homologene: 17647
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: Nope, 9330155G14Rik, WI-16786, WI-18508
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22033
Homologene: 27079
Vgll3
Name: vestigial like family member 3
Synonyms: Vito-2, 1700110N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73569
VEGA: 16
Homologene: 53442
Or5aq1b
Name: olfactory receptor family 5 subfamily AQ member 1B
Synonyms: GA_x6K02T2Q125-48565383-48564445, Olfr1107, MOR172-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258841
Homologene: 131138
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Rpl18a
Name: ribosomal protein L18A
Synonyms: 2510019J09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76808
Homologene: 68104
Sycp3
Name: synaptonemal complex protein 3
Synonyms: Scp3, Cor1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20962
Homologene: 7964
Or4a79
Name: olfactory receptor family 4 subfamily A member 79
Synonyms: Olfr1252, MOR231-22_p, GA_x6K02T2Q125-51162884-51161940
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404331
Homologene: 128094
Fam81b
Name: family with sequence similarity 81, member B
Synonyms: LOC238726
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238726
Homologene: 17616
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,300,662 bp
  • T to C, chromosome 1 at 134,873,942 bp
  • T to A, chromosome 1 at 167,357,380 bp
  • A to T, chromosome 1 at 183,328,207 bp
  • G to T, chromosome 1 at 192,062,684 bp
  • C to T, chromosome 2 at 24,679,176 bp
  • T to A, chromosome 2 at 87,071,673 bp
  • T to C, chromosome 2 at 88,462,083 bp
  • T to A, chromosome 2 at 89,721,842 bp
  • G to A, chromosome 2 at 119,292,756 bp
  • A to G, chromosome 2 at 122,458,201 bp
  • A to G, chromosome 3 at 19,672,847 bp
  • A to G, chromosome 4 at 112,136,021 bp
  • A to G, chromosome 4 at 123,491,698 bp
  • A to T, chromosome 5 at 86,529,910 bp
  • G to A, chromosome 5 at 140,143,979 bp
  • T to C, chromosome 6 at 29,589,214 bp
  • T to C, chromosome 6 at 83,060,241 bp
  • T to A, chromosome 6 at 116,314,208 bp
  • G to A, chromosome 7 at 15,988,470 bp
  • T to C, chromosome 7 at 19,036,793 bp
  • A to G, chromosome 7 at 44,462,405 bp
  • C to A, chromosome 7 at 85,956,019 bp
  • C to T, chromosome 7 at 99,156,980 bp
  • A to T, chromosome 7 at 104,341,958 bp
  • G to A, chromosome 7 at 137,463,007 bp
  • G to T, chromosome 8 at 70,895,425 bp
  • C to T, chromosome 9 at 27,030,718 bp
  • A to G, chromosome 9 at 45,983,849 bp
  • A to T, chromosome 9 at 65,123,971 bp
  • C to T, chromosome 9 at 87,724,358 bp
  • T to A, chromosome 9 at 95,899,060 bp
  • T to C, chromosome 10 at 23,970,851 bp
  • T to C, chromosome 10 at 52,429,320 bp
  • A to G, chromosome 10 at 62,878,807 bp
  • T to C, chromosome 10 at 88,462,605 bp
  • A to T, chromosome 10 at 88,758,444 bp
  • T to C, chromosome 10 at 116,317,378 bp
  • T to C, chromosome 11 at 5,876,842 bp
  • C to T, chromosome 11 at 49,514,223 bp
  • A to G, chromosome 11 at 100,797,781 bp
  • A to T, chromosome 12 at 11,255,050 bp
  • A to T, chromosome 13 at 27,511,581 bp
  • A to G, chromosome 13 at 62,173,120 bp
  • A to C, chromosome 13 at 76,235,021 bp
  • C to T, chromosome 13 at 96,543,228 bp
  • T to C, chromosome 14 at 24,158,327 bp
  • T to C, chromosome 14 at 37,079,652 bp
  • C to T, chromosome 14 at 62,713,737 bp
  • A to T, chromosome 16 at 31,989,310 bp
  • A to T, chromosome 16 at 34,055,044 bp
  • T to C, chromosome 16 at 56,742,513 bp
  • T to C, chromosome 16 at 65,828,078 bp
  • A to G, chromosome 18 at 20,540,073 bp
  • A to T, chromosome 18 at 78,856,800 bp
  • A to G, chromosome 19 at 46,307,434 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8147 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067575-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.