Strain Name:
C57BL/6J-MtgxR8208Btlr/Mmmh
Stock Number:
067631-MU
Citation ID:
RRID:MMRRC_067631-MU
Other Names:
R8208 (G1)
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: 1200015E08Rik, D13Ertd524e, Lgals-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: C330012K04Rik, GalNAc-T10, Galnt9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms: HAC1, trls
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15166
HGNC: HGNC:4846
Homologene: 31022
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Tpst1
Name: protein-tyrosine sulfotransferase 1
Synonyms: Tango13a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22021
Homologene: 2667
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: Crk1, p38alpha, p38 MAP kinase alpha, p38MAPK, p38a, p38 MAP Kinase, p38 alpha, CSBP2, p38-alpha, Mxi2, Csbp1, p38, p38 MAPK
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Ptp4a2
Name: protein tyrosine phosphatase 4a2
Synonyms: Prl-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19244
HGNC: HGNC:9635
Homologene: 20744
Spop
Name: speckle-type BTB/POZ protein
Synonyms: TEF2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20747
Homologene: 68354
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Laptm4b
Name: lysosomal-associated protein transmembrane 4B
Synonyms: C330023P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 114128
VEGA: 15
Homologene: 10182
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: 4930430M16Rik, Bcrp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329559
Homologene: 11129
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Cola-2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Ccp4, EG244071, Nna1-l1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244071
Homologene: 17552
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Colec10
Name: collectin sub-family member 10
Synonyms: CL-L1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239447
VEGA: 15
HGNC: HGNC:2220
Homologene: 31381
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640524
Homologene: 41150
Slc26a2
Name: solute carrier family 26 (sulfate transporter), member 2
Synonyms: Dtd, ST-OB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13521
Homologene: 73876
Or5k3
Name: olfactory receptor family 5 subfamily K member 3
Synonyms: Olfr195, MOR184-5, GA_x54KRFPKG5P-55369823-55370749
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259000
Homologene: 128109
Folh1
Name: folate hydrolase 1
Synonyms: glutamate carboxypeptidase II, mopsm, GCP2, prostate-specific membrane antigen
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53320
Homologene: 55826
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Dennd4b
Name: DENN domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229541
Homologene: 28281
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Hirip3
Name: HIRA interacting protein 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233876
HGNC: HGNC:4917
Homologene: 18218
Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Synonyms: Cyp46, cholestrol 24-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13116
VEGA: 12
HGNC: HGNC:2641
Homologene: 134501
Or10ag53
Name: olfactory receptor family 10 subfamily AG member 53
Synonyms: GA_x6K02T2Q125-48736906-48737886, MOR273-4P, Olfr1530-ps1, Olfr1115, MOR273-4P, MOR264-20
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258294
Homologene: 27114
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, EMILIN-1, gp115
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100952
Homologene: 5117
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: 2810049L19Rik, Gcl, mglc-1, Btbd13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23885
Homologene: 8021
Serpina5
Name: serine (or cysteine) peptidase inhibitor, clade A, member 5
Synonyms: Pci, alpha-1 antiproteinase, antitrypsin, PAI-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268591
HGNC: HGNC:8723
Homologene: 20159
Or56a5
Name: olfactory receptor family 56 subfamily A member 5
Synonyms: Olfr683, GA_x6K02T2PBJ9-7773007-7772066, MOR40-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259047
Homologene: 133645
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546913
Homologene: 84037
Sec61a2
Name: SEC61 translocon subunit alpha 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57743
Homologene: 38481
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: MOR106-11, GA_x6K02T2PMLR-6361495-6362481, Olfr745
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Vmn1r200
Name: vomeronasal 1 receptor 200
Synonyms: V1rh3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171246
Homologene: 110880
Ndufaf1
Name: NADH:ubiquinone oxidoreductase complex assembly factor 1
Synonyms: CGI-65, 2410001M24Rik, CIA30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69702
Homologene: 32289
Hsfy2
Name: heat shock transcription factor, Y-linked 2
Synonyms: 4933413G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71066
Homologene: 134090
Rab2b
Name: RAB2B, member RAS oncogene family
Synonyms: D530043M21Rik, 4930528G15Rik, 1500012D09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76338
Homologene: 23789
Mxd4
Name: Max dimerization protein 4
Synonyms: bHLHc12, Mad4, 2810410A03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17122
Homologene: 4712
Mfsd7c
Name:
Type: Gene
Species: Mouse
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 56,637,151 bp
  • G to T, chromosome 1 at 188,874,793 bp
  • G to T, chromosome 2 at 5,876,998 bp
  • A to G, chromosome 2 at 31,887,414 bp
  • T to C, chromosome 2 at 76,725,848 bp
  • A to G, chromosome 2 at 87,252,663 bp
  • T to C, chromosome 2 at 113,842,939 bp
  • T to C, chromosome 2 at 119,660,346 bp
  • T to A, chromosome 2 at 120,047,845 bp
  • C to A, chromosome 2 at 164,893,616 bp
  • T to A, chromosome 3 at 90,270,971 bp
  • C to T, chromosome 4 at 129,842,692 bp
  • A to G, chromosome 5 at 30,917,516 bp
  • A to T, chromosome 5 at 34,177,726 bp
  • A to G, chromosome 5 at 130,101,910 bp
  • T to A, chromosome 6 at 4,515,260 bp
  • C to T, chromosome 6 at 28,526,055 bp
  • G to A, chromosome 6 at 58,665,242 bp
  • A to G, chromosome 6 at 86,721,399 bp
  • T to A, chromosome 6 at 123,637,485 bp
  • A to G, chromosome 7 at 12,601,395 bp
  • T to A, chromosome 7 at 76,720,168 bp
  • A to T, chromosome 7 at 86,725,917 bp
  • G to T, chromosome 7 at 92,649,523 bp
  • T to A, chromosome 7 at 105,143,418 bp
  • G to T, chromosome 7 at 126,864,423 bp
  • T to A, chromosome 8 at 91,037,263 bp
  • T to A, chromosome 10 at 79,730,944 bp
  • T to C, chromosome 11 at 30,124,972 bp
  • A to T, chromosome 11 at 57,645,572 bp
  • A to G, chromosome 11 at 69,520,852 bp
  • C to T, chromosome 11 at 95,491,824 bp
  • GTAGTGTATA to GTA, chromosome 12 at 85,803,148 bp
  • A to G, chromosome 12 at 104,105,273 bp
  • A to T, chromosome 12 at 108,351,912 bp
  • A to G, chromosome 13 at 12,453,374 bp
  • G to A, chromosome 13 at 22,395,300 bp
  • T to C, chromosome 14 at 50,642,631 bp
  • C to T, chromosome 14 at 52,264,767 bp
  • G to A, chromosome 15 at 34,277,445 bp
  • C to G, chromosome 15 at 54,462,300 bp
  • G to A, chromosome 15 at 80,858,700 bp
  • C to A, chromosome 16 at 59,149,019 bp
  • A to T, chromosome 17 at 28,724,833 bp
  • T to C, chromosome 17 at 50,608,315 bp
  • T to C, chromosome 18 at 10,510,703 bp
  • C to T, chromosome 18 at 61,198,734 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8208 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067631-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.