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Strain Name:
C57BL/6J-MtgxR8342Btlr/Mmmh
Stock Number:
067731-MU
Citation ID:
RRID:MMRRC_067731-MU
Other Names:
R8342 (G1)
Major Collection:

Strain Information

Eno1
Name: enolase 1, alpha non-neuron
Synonyms: 2-phospho-D-glycerate hydrolase, alpha-enolase, Eno-1, MBP-1, c-Myc promoter binding protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Ppm1a
Name: protein phosphatase 1A, magnesium dependent, alpha isoform
Synonyms: Mpp alpha, MMPa-2, MPPa-1, 2900017D14Rik, 2310003C21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19042
VEGA: 12
HGNC: HGNC:9275
Homologene: 56428
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Arrdc3
Name: arrestin domain containing 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105171
Homologene: 69318
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 72,652,460 bp
  • T to C, chromosome 1 at 88,095,251 bp
  • G to T, chromosome 2 at 15,633,224 bp
  • T to A, chromosome 2 at 23,257,005 bp
  • T to C, chromosome 2 at 37,146,766 bp
  • G to T, chromosome 2 at 66,536,282 bp
  • T to C, chromosome 2 at 76,889,441 bp
  • A to G, chromosome 2 at 91,488,445 bp
  • T to A, chromosome 2 at 91,606,362 bp
  • T to C, chromosome 2 at 116,880,253 bp
  • A to T, chromosome 2 at 180,603,390 bp
  • T to C, chromosome 3 at 37,079,901 bp
  • C to T, chromosome 3 at 60,086,734 bp
  • A to G, chromosome 3 at 119,314,803 bp
  • A to T, chromosome 4 at 101,910,384 bp
  • C to T, chromosome 4 at 111,119,027 bp
  • T to A, chromosome 4 at 143,994,239 bp
  • T to C, chromosome 4 at 149,222,348 bp
  • A to G, chromosome 4 at 150,245,236 bp
  • G to A, chromosome 5 at 5,740,816 bp
  • A to G, chromosome 5 at 18,003,840 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to G, chromosome 6 at 86,986,339 bp
  • A to T, chromosome 7 at 17,752,246 bp
  • A to T, chromosome 7 at 41,374,886 bp
  • A to T, chromosome 7 at 42,141,070 bp
  • A to T, chromosome 7 at 44,016,084 bp
  • A to T, chromosome 7 at 130,503,765 bp
  • T to C, chromosome 7 at 132,247,886 bp
  • A to T, chromosome 7 at 141,860,865 bp
  • A to C, chromosome 8 at 11,529,706 bp
  • C to A, chromosome 8 at 31,822,306 bp
  • A to G, chromosome 8 at 69,101,383 bp
  • C to A, chromosome 9 at 14,781,527 bp
  • A to G, chromosome 9 at 18,658,685 bp
  • A to T, chromosome 9 at 37,238,214 bp
  • A to C, chromosome 9 at 39,840,316 bp
  • A to G, chromosome 9 at 95,726,548 bp
  • A to G, chromosome 9 at 119,139,389 bp
  • T to C, chromosome 10 at 5,108,622 bp
  • G to A, chromosome 10 at 33,866,521 bp
  • A to T, chromosome 10 at 42,568,429 bp
  • A to T, chromosome 10 at 86,467,027 bp
  • G to A, chromosome 10 at 127,693,029 bp
  • C to T, chromosome 11 at 5,990,383 bp
  • C to T, chromosome 12 at 35,508,272 bp
  • A to T, chromosome 12 at 69,754,178 bp
  • G to A, chromosome 12 at 72,784,135 bp
  • T to C, chromosome 12 at 83,808,216 bp
  • T to C, chromosome 13 at 73,785,162 bp
  • A to G, chromosome 13 at 80,883,671 bp
  • T to A, chromosome 14 at 39,012,096 bp
  • T to C, chromosome 14 at 56,042,793 bp
  • C to A, chromosome 14 at 70,166,114 bp
  • A to T, chromosome 15 at 31,494,116 bp
  • A to G, chromosome 15 at 38,024,837 bp
  • T to C, chromosome 16 at 49,092,757 bp
  • C to T, chromosome 16 at 59,622,439 bp
  • A to T, chromosome 17 at 32,690,759 bp
  • A to G, chromosome 18 at 32,413,113 bp
  • C to T, chromosome 18 at 35,622,535 bp
  • G to A, chromosome 18 at 77,405,985 bp
  • C to A, chromosome 19 at 17,125,663 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067731-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.