Strain Name:
C57BL/6J-MtgxR8369Btlr/Mmmh
Stock Number:
067739-MU
Citation ID:
RRID:MMRRC_067739-MU
Other Names:
R8369 (G1)
Major Collection:

Strain Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: Grg4, ESTM13, ESTM14, Bce1, 5730411M05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70829
Homologene: 10393
Abcc4
Name: ATP-binding cassette, sub-family C member 4
Synonyms: D630049P08Rik, MOAT-B, MRP4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Tirap
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Synonyms: wyatt, MyD88-adapter-like, Mal, C130027E04Rik, Mal
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 117149
Homologene: 14285
Wwc1
Name: WW, C2 and coiled-coil domain containing 1
Synonyms: Kibra
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211652
Homologene: 69180
Txnrd1
Name: thioredoxin reductase 1
Synonyms: TrxR1, TR1, TR alpha, TR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50493
VEGA: 10
Homologene: 55733
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Cyb5r4
Name: cytochrome b5 reductase 4
Synonyms: B5+B5R, b5/b5r, 2810034J18Rik, Ncb5or
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 266690
Homologene: 69207
Ermard
Name: ER membrane associated RNA degradation
Synonyms: 2410011O22Rik, 2210404J11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381062
Homologene: 19936
Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Synonyms: Ercc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13870
HGNC: HGNC:3433
Homologene: 1501
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK-beta, IKK-2, IKK2, IKK[b], IKKbeta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Srek1ip1
Name: splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
Synonyms: 3110031B13Rik, Sfrs12ip1, Srsf12ip1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67288
Dcaf6
Name: DDB1 and CUL4 associated factor 6
Synonyms: PC326, 1200006M05Rik, Iqwd1, NRIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74106
Homologene: 10199
Arhgap44
Name: Rho GTPase activating protein 44
Synonyms: AU040829
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216831
Homologene: 65284
Zfp979
Name: zinc finger protein 979
Synonyms: 2610305D13Rik, Ssm1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 112422
Homologene: 133076
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Pcolce2
Name: procollagen C-endopeptidase enhancer 2
Synonyms: Pcpe2, 2400001O18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76477
HGNC: HGNC:8739
Homologene: 8357
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, D6Abb2e, wms, jog, Tmy, Gena300
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Naxe
Name: NAD(P)HX epimerase
Synonyms: ESTM37, APOA1BP, AI-BP, Apoa1bp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 246703
Homologene: 70948
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: Arhgap14, D130026O08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Tnfaip8l2
Name: tumor necrosis factor, alpha-induced protein 8-like 2
Synonyms: 1810019A08Rik, Tipe2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69769
Homologene: 56998
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Slc7a6
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Synonyms: LAT-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330836
Homologene: 62496
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, D10Bwg1379e, BIG3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Krt24
Name: keratin 24
Synonyms: 2310075C18Rik, 2310058N18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75706
Homologene: 10379
Epcip
Name: exosomal polycystin 1 interacting protein
Synonyms: 4932438H23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74387
HGNC: HGNC:1305
Homologene: 49594
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbccr1, Fam5a, Dbc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Zfp9
Name: zinc finger protein 9
Synonyms: Krox-4, Zfp-9, 1810048F22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22750
Homologene: 49280
Yod1
Name: YOD1 deubiquitinase
Synonyms: 9930028C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226418
Homologene: 13176
N4bp3
Name: NEDD4 binding protein 3
Synonyms: C330016O10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 212706
Homologene: 17124
Gcsam
Name: germinal center associated, signaling and motility
Synonyms: M17, Gcet2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14525
Homologene: 49157
Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Synonyms: 1300010A18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 79235
HGNC: HGNC:6685
Homologene: 3483
Thoc3
Name: THO complex 3
Synonyms: 2410044K02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73666
Homologene: 12505
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106648
Homologene: 80199
Dnajc5b
Name: DnaJ heat shock protein family (Hsp40) member C5 beta
Synonyms: 1700008A05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66326
Homologene: 32634
Sult2a6
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6
Synonyms: Gm6957
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629219
Homologene: 37741
Cygb
Name: cytoglobin
Synonyms: 3110001K20Rik, Staap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114886
Homologene: 12706
Sord
Name: sorbitol dehydrogenase
Synonyms: Sdh-1, Sodh-1, Sdh1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20322
Homologene: 56080
Misp3
Name: MISP family member 3
Synonyms: 2210011C24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70134
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 121,477,868 bp
  • T to G, chromosome 1 at 121,494,397 bp
  • A to G, chromosome 1 at 130,717,623 bp
  • T to C, chromosome 1 at 165,357,474 bp
  • T to A, chromosome 2 at 38,048,754 bp
  • T to A, chromosome 2 at 122,246,495 bp
  • G to A, chromosome 2 at 142,711,857 bp
  • C to A, chromosome 2 at 156,019,760 bp
  • A to G, chromosome 3 at 19,610,632 bp
  • T to A, chromosome 3 at 37,011,603 bp
  • T to C, chromosome 3 at 82,903,558 bp
  • T to C, chromosome 3 at 88,056,687 bp
  • T to A, chromosome 3 at 95,140,175 bp
  • A to T, chromosome 4 at 68,798,699 bp
  • T to A, chromosome 4 at 88,232,668 bp
  • T to C, chromosome 4 at 147,613,091 bp
  • G to A, chromosome 5 at 62,604,326 bp
  • A to G, chromosome 5 at 109,221,476 bp
  • A to C, chromosome 6 at 112,722,818 bp
  • C to T, chromosome 6 at 113,813,786 bp
  • C to A, chromosome 6 at 118,464,392 bp
  • A to C, chromosome 7 at 14,253,402 bp
  • T to A, chromosome 7 at 19,354,452 bp
  • T to C, chromosome 7 at 100,395,258 bp
  • T to A, chromosome 7 at 130,622,158 bp
  • A to G, chromosome 8 at 22,691,081 bp
  • T to A, chromosome 8 at 84,010,998 bp
  • G to A, chromosome 8 at 106,193,164 bp
  • T to C, chromosome 8 at 108,856,816 bp
  • A to G, chromosome 9 at 35,188,756 bp
  • A to T, chromosome 9 at 87,040,433 bp
  • A to T, chromosome 9 at 95,637,794 bp
  • A to T, chromosome 10 at 18,589,729 bp
  • A to G, chromosome 10 at 82,874,646 bp
  • G to A, chromosome 11 at 35,867,371 bp
  • A to G, chromosome 11 at 51,644,426 bp
  • A to T, chromosome 11 at 65,059,854 bp
  • A to T, chromosome 11 at 99,282,708 bp
  • G to A, chromosome 11 at 116,649,283 bp
  • A to G, chromosome 13 at 54,467,895 bp
  • A to T, chromosome 13 at 95,661,603 bp
  • A to G, chromosome 13 at 104,834,290 bp
  • A to T, chromosome 14 at 55,066,744 bp
  • T to G, chromosome 14 at 118,627,457 bp
  • T to A, chromosome 16 at 45,616,006 bp
  • G to A, chromosome 16 at 91,055,769 bp
  • T to C, chromosome 17 at 15,053,298 bp
  • T to A, chromosome 17 at 32,697,965 bp
  • G to T, chromosome 17 at 33,912,616 bp
  • T to C, chromosome 19 at 14,452,512 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8369 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067739-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.