Strain Name:
C57BL/6J-MtgxR8436Btlr/Mmmh
Stock Number:
067777-MU
Citation ID:
RRID:MMRRC_067777-MU
Other Names:
R8436 (G1)
Major Collection:

Strain Information

Sall4
Name: spalt like transcription factor 4
Synonyms: Tex20, 5730441M18Rik, C330011P20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99377
Homologene: 10716
Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms: 1700091C19Rik, 2900019G14Rik, Eaat2, GLT-1, GLT1, MGLT1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20511
Homologene: 3075
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Rnd1
Name: Rho family GTPase 1
Synonyms: A830014L09Rik, Arhs
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223881
Homologene: 8706
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kcr2-4, Kv3.4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
Nf1
Name: neurofibromin 1
Synonyms: Mhdadsk9, neurofibromin, Nf-1, Dsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: WSTF, Wbscr9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Vipas39
Name: VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Synonyms: SPE-39, Vipar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104799
VEGA: 12
Homologene: 41464
Tceanc2
Name: transcription elongation factor A (SII) N-terminal and central domain containing 2
Synonyms: Tdeanc2, 2210012G02Rik, 6330404A07Rik, 2210010B22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66526
Homologene: 11984
Chrdl2
Name: chordin-like 2
Synonyms: Chl2, 1810022C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69121
Homologene: 128795
Tmco1
Name: transmembrane and coiled-coil domains 1
Synonyms: 1190006A08Rik, ESTM39, 4930403O06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68944
Homologene: 10384
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Hisppd1, Vip2, Cfap160
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227399
Homologene: 49409
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 271377
Homologene: 8678
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Zscan21
Name: zinc finger and SCAN domain containing 21
Synonyms: Zfp-38, Zipro1, RU49, CTfin51, Zfp38
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22697
Homologene: 56530
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14789
Homologene: 8401
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Gm4884
Name: predicted gene 4884
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233164
Cdt1
Name: chromatin licensing and DNA replication factor 1
Synonyms: 2610318F11Rik, Ris2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67177
Homologene: 32650
Irs1
Name: insulin receptor substrate 1
Synonyms: G972R, IRS-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Ifngr1
Name: interferon gamma receptor 1
Synonyms: CD119, Ifgr, IFN-gamma R, IFN-gammaR, Ifngr, Nktar
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15979
HGNC: HGNC:5439
Homologene: 359
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: SZP, MSF, DOL54, lubricin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Irf2
Name: interferon regulatory factor 2
Synonyms: Irf-2, 9830146E22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16363
HGNC: HGNC:6117
Homologene: 1659
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Pdk2
Name: pyruvate dehydrogenase kinase, isoenzyme 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18604
HGNC: HGNC:8810
Homologene: 68265
Emcn
Name: endomucin
Synonyms: 0610012K22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59308
Homologene: 9438
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Cpb2
Name: carboxypeptidase B2
Synonyms: CPR, TAFI, thrombin-activatable fibrinolysis inhibitor, carboxypeptidase R, 4930405E17Rik, 1110032P04Rik, CPU, carboxypeptidase U
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56373
VEGA: 14
HGNC: HGNC:2300
Homologene: 55610
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Vmn1r86
Name: vomeronasal 1 receptor 86
Synonyms: Gm10301
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312473
Homologene: 74345
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Gm4353
Name: predicted gene 4353
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043313
VEGA: 7
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: Wdr20b, 4921538B03Rik, 4930427E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70948
VEGA: 12
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Prl2b1
Name: prolactin family 2, subfamily b, member 1
Synonyms: PLP-K, 2310047B08Rik, Prlpk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66392
Homologene: 11963
Mpi
Name: mannose phosphate isomerase
Synonyms: 1110002E17Rik, Mpi-1, Mpi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110119
HGNC: HGNC:7216
Homologene: 1825
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: 4930485B16Rik, Gm872, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Tnfsf12
Name: tumor necrosis factor (ligand) superfamily, member 12
Synonyms: APO3L, Tweak, DR3L
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21944
Homologene: 7979
Cfap99
Name: cilia and flagella associated protein 99
Synonyms: Gm21446
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862066
Homologene: 82544
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 82,290,249 bp
  • T to C, chromosome 1 at 97,755,888 bp
  • G to T, chromosome 1 at 150,455,567 bp
  • A to G, chromosome 1 at 167,308,685 bp
  • G to A, chromosome 2 at 102,755,953 bp
  • G to A, chromosome 2 at 168,755,910 bp
  • T to C, chromosome 2 at 178,362,968 bp
  • G to T, chromosome 3 at 107,458,768 bp
  • A to G, chromosome 3 at 137,423,467 bp
  • G to A, chromosome 4 at 58,044,053 bp
  • G to A, chromosome 4 at 107,177,581 bp
  • G to A, chromosome 4 at 154,265,192 bp
  • A to G, chromosome 5 at 34,311,682 bp
  • A to G, chromosome 5 at 109,363,783 bp
  • A to G, chromosome 5 at 121,308,358 bp
  • A to G, chromosome 5 at 121,343,147 bp
  • A to G, chromosome 5 at 135,237,967 bp
  • A to T, chromosome 5 at 138,117,916 bp
  • C to A, chromosome 6 at 124,851,078 bp
  • A to G, chromosome 7 at 13,102,844 bp
  • G to A, chromosome 7 at 41,043,386 bp
  • G to A, chromosome 7 at 100,027,733 bp
  • A to G, chromosome 7 at 116,083,629 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • C to T, chromosome 8 at 46,818,894 bp
  • C to T, chromosome 8 at 122,569,331 bp
  • A to T, chromosome 9 at 57,544,917 bp
  • T to C, chromosome 9 at 111,391,382 bp
  • T to C, chromosome 10 at 5,228,659 bp
  • T to C, chromosome 10 at 19,603,805 bp
  • A to T, chromosome 10 at 92,964,536 bp
  • T to C, chromosome 11 at 69,686,887 bp
  • A to G, chromosome 11 at 79,458,883 bp
  • C to T, chromosome 11 at 82,792,044 bp
  • A to T, chromosome 11 at 95,039,433 bp
  • T to A, chromosome 12 at 65,226,261 bp
  • T to A, chromosome 12 at 87,257,417 bp
  • T to C, chromosome 13 at 27,383,459 bp
  • C to A, chromosome 14 at 75,272,575 bp
  • A to T, chromosome 15 at 48,004,822 bp
  • C to T, chromosome 15 at 73,562,349 bp
  • A to G, chromosome 15 at 82,065,735 bp
  • T to A, chromosome 15 at 98,676,574 bp
  • T to A, chromosome 16 at 56,000,659 bp
  • A to C, chromosome 18 at 31,440,419 bp
  • A to G, chromosome 19 at 16,740,793 bp
  • C to T, chromosome 19 at 48,206,474 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8436 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067777-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.