Strain Name:
C57BL/6J-MtgxR8752Btlr/Mmmh
Stock Number:
068595-MU
Citation ID:
RRID:MMRRC_068595-MU
Other Names:
R8752 (G1)
Major Collection:

Strain Information

Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: PRCE, Cerp, PRCE, SSE, ESP1, separase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Sfpq
Name: splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
Synonyms: D4Ertd314e, 2810416M14Rik, 1110004P21Rik, REP1, 5730453G22Rik, PSF, 9030402K04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71514
Homologene: 3714
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: 9530001P15Rik, Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Id4
Name: inhibitor of DNA binding 4
Synonyms: Idb4, bHLHb27, Id4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15904
VEGA: 13
HGNC: HGNC:5363
Homologene: 1186
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: E230037B21Rik, p193, Adprtl1, VAULT3, C030027K23Rik, PH5P, VPARP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Hsf1
Name: heat shock factor 1
Synonyms: heat shock transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15499
VEGA: 15
HGNC: HGNC:5224
Homologene: 74556
Xpo5
Name: exportin 5
Synonyms: 2410004H11Rik, Exp5, 2700038C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72322
VEGA: 17
Homologene: 69316
Gata2
Name: GATA binding protein 2
Synonyms: Gata-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14461
HGNC: HGNC:4171
Homologene: 32030
Etv6
Name: ets variant 6
Synonyms: Tel, translocation-ets-leukemia
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14011
HGNC: HGNC:3495
Homologene: 37560
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Muc15
Name: mucin 15
Synonyms: D730046L02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269328
Homologene: 51680
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: calumin, asp4, 2610204L23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
Deptor
Name: DEP domain containing MTOR-interacting protein
Synonyms: D15Ertd336e, Depdc6, 9130412E02Rik, 4731402B04Rik, D15Ertd597e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 97998
Homologene: 32551
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Ndst3
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms: 4921531K01Rik, 4930511P15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83398
HGNC: HGNC:7682
Homologene: 3513
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1565Clo, b2b3491Clo, Mdnah5, b2b1154Clo, b2b1537Clo, Dnahc5, b2b1134Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: myoclonin1, mRib72-1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Mipol1
Name: mirror-image polydactyly 1
Synonyms: D12Ertd19e, 1700081O04Rik, 6030439O22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73490
Homologene: 16340
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: A930027I18Rik, Ifnm, IL-12RB2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Afm
Name: afamin
Synonyms: alpha albumin, Alf
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, steerin 3, unc53H3, 9630020C08Rik, 4732483H20Rik, POMFIL1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Nhsl1
Name: NHS like 1
Synonyms: D10Bwg0940e, A630035H13Rik, 5730409E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215819
Homologene: 27834
Nek11
Name: NIMA (never in mitosis gene a)-related expressed kinase 11
Synonyms: 4932416N14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208583
Homologene: 57008
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: CATSPERG, 1700067C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76718
Homologene: 10915
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: GA_x6K02T2QD9B-18838170-18837232, Olfr1341, MOR258-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258852
Homologene: 27281
Or4c111
Name: olfactory receptor family 4 subfamily C member 111
Synonyms: GA_x6K02T2Q125-50494588-50493653, Olfr1216, MOR233-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258895
Homologene: 74241
Vmn1r216
Name: vomeronasal 1 receptor 216
Synonyms: V1ri10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171279
Homologene: 110880
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-4, Es-1, Ces-N, Es1, Ee-1, Es-N
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Or5w20
Name: olfactory receptor family 5 subfamily W member 20
Synonyms: Olfr1153, MOR177-7, GA_x6K02T2Q125-49395950-49396882
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258633
Homologene: 27230
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232367
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Or2v1
Name: olfactory receptor family 2 subfamily V member 1
Synonyms: Olfr56, MOR276-1, GA_x6K02T2QP88-6300500-6299553, IF7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18356
HGNC: HGNC:8280
Homologene: 22608
Lcn11
Name: lipocalin 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227630
Homologene: 129702
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Adat2
Name: adenosine deaminase, tRNA-specific 2
Synonyms: Deadc1, 4933426M09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66757
Homologene: 6262
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Gpr45
Name: G protein-coupled receptor 45
Synonyms: 9230112G11Rik, PSP24alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93690
HGNC: HGNC:4503
Homologene: 5228
Vmn2r95
Name: vomeronasal 2, receptor 95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328759
Homologene: 115024
Mpp2
Name: membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Synonyms: Dlg2, Dlgh2, Pals4, D11Bwg0652e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50997
HGNC: HGNC:7220
Homologene: 3920
Foxd4
Name: forkhead box D4
Synonyms: Fkh2, FREAC5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14237
VEGA: 19
Homologene: 83248
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: 2310081N20Rik, acid ceramidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69324
Homologene: 78000
Or5p72
Name: olfactory receptor family 5 subfamily P member 72
Synonyms: GA_x6K02T2PBJ9-10752603-10753547, Olfr497, MOR204-9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258733
Homologene: 133602
Pla2g4d
Name: phospholipase A2, group IVD
Synonyms: 2610311B01Rik, Pla2delta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78390
Homologene: 52252
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Rhod
Name: ras homolog family member D
Synonyms: Arhd
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11854
HGNC: HGNC:670
Homologene: 22409
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Acad8
Name: acyl-Coenzyme A dehydrogenase family, member 8
Synonyms: 2310016C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66948
HGNC: HGNC:87
Homologene: 8662
Psmc2
Name: proteasome (prosome, macropain) 26S subunit, ATPase 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19181
HGNC: HGNC:9548
Homologene: 2096
Pramel52-ps
Name: PRAME like 52, pseudogene
Synonyms: AA792892
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100554
Homologene: 133359
Cd302
Name: CD302 antigen
Synonyms: 1110055L24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66205
Homologene: 8919
Dnajc4
Name: DnaJ heat shock protein family (Hsp40) member C4
Synonyms: Mcg18, Hspf2, 2010301J22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57431
VEGA: 19
HGNC: HGNC:5271
Homologene: 73264
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,989,468 bp
  • A to T, chromosome 1 at 43,032,682 bp
  • A to G, chromosome 1 at 46,672,541 bp
  • G to A, chromosome 1 at 181,628,016 bp
  • T to C, chromosome 2 at 25,778,126 bp
  • A to T, chromosome 2 at 29,158,980 bp
  • A to G, chromosome 2 at 60,272,185 bp
  • T to C, chromosome 2 at 87,896,247 bp
  • T to C, chromosome 2 at 89,013,887 bp
  • A to T, chromosome 2 at 110,731,413 bp
  • A to T, chromosome 2 at 120,268,767 bp
  • C to T, chromosome 3 at 123,549,035 bp
  • A to C, chromosome 4 at 118,709,886 bp
  • T to A, chromosome 4 at 127,026,176 bp
  • A to C, chromosome 4 at 128,585,687 bp
  • A to G, chromosome 5 at 21,796,535 bp
  • A to C, chromosome 5 at 90,552,565 bp
  • A to T, chromosome 5 at 94,381,495 bp
  • T to C, chromosome 6 at 67,351,281 bp
  • T to C, chromosome 6 at 88,200,531 bp
  • A to G, chromosome 6 at 124,224,059 bp
  • A to G, chromosome 6 at 134,266,428 bp
  • A to G, chromosome 7 at 8,367,806 bp
  • T to C, chromosome 7 at 29,705,319 bp
  • A to T, chromosome 7 at 39,408,503 bp
  • T to C, chromosome 7 at 51,546,869 bp
  • C to A, chromosome 7 at 75,206,094 bp
  • T to C, chromosome 7 at 108,423,273 bp
  • G to A, chromosome 8 at 41,360,277 bp
  • A to T, chromosome 8 at 55,872,293 bp
  • C to G, chromosome 8 at 93,120,336 bp
  • A to T, chromosome 9 at 26,985,557 bp
  • G to T, chromosome 9 at 105,348,008 bp
  • A to T, chromosome 10 at 13,556,860 bp
  • A to G, chromosome 10 at 18,531,365 bp
  • T to C, chromosome 10 at 109,760,304 bp
  • T to A, chromosome 11 at 49,134,678 bp
  • A to G, chromosome 11 at 75,169,380 bp
  • A to G, chromosome 11 at 102,085,303 bp
  • A to G, chromosome 11 at 106,204,992 bp
  • T to C, chromosome 11 at 109,813,570 bp
  • G to A, chromosome 12 at 57,325,581 bp
  • AAGGAG to AAG, chromosome 12 at 105,747,217 bp
  • G to T, chromosome 13 at 23,099,710 bp
  • A to T, chromosome 13 at 48,261,589 bp
  • A to T, chromosome 13 at 96,780,371 bp
  • C to A, chromosome 14 at 31,755,742 bp
  • G to T, chromosome 14 at 56,648,616 bp
  • A to G, chromosome 15 at 28,290,219 bp
  • A to T, chromosome 15 at 55,180,884 bp
  • C to A, chromosome 15 at 76,500,144 bp
  • A to G, chromosome 15 at 102,306,324 bp
  • T to C, chromosome 17 at 18,441,476 bp
  • C to T, chromosome 17 at 46,236,912 bp
  • T to A, chromosome 18 at 5,060,366 bp
  • G to T, chromosome 19 at 4,426,093 bp
  • C to T, chromosome 19 at 6,989,433 bp
  • T to A, chromosome 19 at 9,015,537 bp
  • A to T, chromosome 19 at 24,900,730 bp
  • C to T, chromosome 19 at 40,361,428 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8752 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068595-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.