Strain Name:
C57BL/6J-MtgxR8797Btlr/Mmmh
Stock Number:
068638-MU
Citation ID:
RRID:MMRRC_068638-MU
Other Names:
R8797 (G1)
Major Collection:

Strain Information

Baiap2
Name: brain-specific angiogenesis inhibitor 1-associated protein 2
Synonyms: IRSp53
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108100
HGNC: HGNC:947
Homologene: 9697
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214669
Homologene: 12882
Nf1
Name: neurofibromin 1
Synonyms: Mhdadsk9, neurofibromin, Nf-1, Dsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22323
Homologene: 7592
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, Iars, 2510016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: Nkcc1, mBSC2, sodium/potassium/chloride cotransporters, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: A330032P03Rik, 2700078H01Rik, RPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Spt16, Fact140, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Sgcb
Name: sarcoglycan, beta (dystrophin-associated glycoprotein)
Synonyms: beta-SG
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24051
Homologene: 195
Zc3h18
Name: zinc finger CCCH-type containing 18
Synonyms: 1190001B23Rik, 5830416A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76014
Homologene: 44894
Zfp981
Name: zinc finger protein 981
Synonyms: Gm13247
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041433
Homologene: 133076
Gpihbp1
Name: GPI-anchored HDL-binding protein 1
Synonyms: GPI-HBP1, 1110002J19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68453
Homologene: 136164
Rps3
Name: ribosomal protein S3
Synonyms: D7Ertd795e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27050
Homologene: 779
Lct
Name: lactase
Synonyms: LOC226413, LPH, Lphl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: b2b585Clo, PC6, SPC6, PC5/6A, PC5A, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
G6pc2
Name: glucose-6-phosphatase, catalytic, 2
Synonyms: IGRP, islet specific glucose-6-phosphatase, G6pc-rs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14378
Homologene: 41423
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Sla2
Name: Src-like-adaptor 2
Synonyms: SLAP2, A930009E21Rik, SLAP-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77799
Homologene: 49989
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Ccna1
Name: cyclin A1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12427
HGNC: HGNC:1577
Homologene: 31203
Psd4
Name: pleckstrin and Sec7 domain containing 4
Synonyms: EFA6B, SEC7 homolog
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215632
Homologene: 8261
Myrfl
Name: myelin regulatory factor-like
Synonyms: Gm239, LOC237558
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Nrg3
Name: neuregulin 3
Synonyms: ska
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18183
HGNC: HGNC:7999
Homologene: 32051
Saxo4
Name: stabilizer of axonemal microtubules 4
Synonyms: IIIG9S, IIIG9L, Ppp1r32, IIIG9, 4930579J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: Mitsugumin 56, Mg56, 1110011D13Rik, Gup1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Meis2
Name: Meis homeobox 2
Synonyms: Mrg1, Stra10, A430109D20Rik, Meis2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Ms4a13
Name: membrane-spanning 4-domains, subfamily A, member 13
Synonyms: 1700060E18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73466
Homologene: 77851
Or2y8
Name: olfactory receptor family 2 subfamily Y member 8
Synonyms: GA_x6K02T2QP88-3283154-3284089, MOR256-69_p, Olfr1373
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211472
Homologene: 72463
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272428
Homologene: 69242
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: Adamts-14, TS14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Or13j1
Name: olfactory receptor family 13 subfamily J member 1
Synonyms: GA_x6K02T2N78B-16230286-16231224, Olfr71, MOR262-4, mOR17
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56015
Homologene: 10460
Or6c65
Name: olfactory receptor family 6 subfamily C member 65
Synonyms: Olfr808, MOR112-2, GA_x6K02T2PULF-11446184-11447122
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258930
Homologene: 17438
Uqcrc2
Name: ubiquinol cytochrome c reductase core protein 2
Synonyms: 1500004O06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67003
Homologene: 37764
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: neuferricin, 9330151E16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192986
Homologene: 14701
H2bc4
Name: H2B clustered histone 4
Synonyms: Hist1h2bc, H2bfs, 2610022J01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68024
Homologene: 135944
Crygc
Name: crystallin, gamma C
Synonyms: Cryg-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12966
HGNC: HGNC:2410
Homologene: 36281
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,123,646 bp
  • C to T, chromosome 1 at 65,071,871 bp
  • T to C, chromosome 1 at 105,750,396 bp
  • T to C, chromosome 1 at 128,303,947 bp
  • T to A, chromosome 1 at 135,974,835 bp
  • C to A, chromosome 1 at 181,637,847 bp
  • A to T, chromosome 2 at 24,397,428 bp
  • A to G, chromosome 2 at 69,220,097 bp
  • T to C, chromosome 2 at 115,864,505 bp
  • A to G, chromosome 2 at 156,875,879 bp
  • G to A, chromosome 2 at 156,875,903 bp
  • T to A, chromosome 2 at 157,229,956 bp
  • G to A, chromosome 3 at 38,999,129 bp
  • C to T, chromosome 3 at 55,045,648 bp
  • T to C, chromosome 4 at 43,706,455 bp
  • T to A, chromosome 4 at 146,535,449 bp
  • A to G, chromosome 5 at 35,029,571 bp
  • G to T, chromosome 5 at 73,635,693 bp
  • A to G, chromosome 7 at 11,670,038 bp
  • T to C, chromosome 7 at 19,260,638 bp
  • A to G, chromosome 7 at 99,483,590 bp
  • C to A, chromosome 7 at 119,538,151 bp
  • A to G, chromosome 7 at 120,640,277 bp
  • A to T, chromosome 8 at 109,648,314 bp
  • T to C, chromosome 8 at 122,408,250 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • T to C, chromosome 9 at 35,478,635 bp
  • A to T, chromosome 9 at 121,790,899 bp
  • C to T, chromosome 10 at 61,271,002 bp
  • T to A, chromosome 10 at 67,224,837 bp
  • A to G, chromosome 10 at 74,584,146 bp
  • T to A, chromosome 10 at 84,697,015 bp
  • T to C, chromosome 10 at 116,777,420 bp
  • T to A, chromosome 10 at 129,767,805 bp
  • T to A, chromosome 11 at 52,145,513 bp
  • T to G, chromosome 11 at 72,778,836 bp
  • T to C, chromosome 11 at 79,475,885 bp
  • C to T, chromosome 11 at 102,676,860 bp
  • T to G, chromosome 11 at 118,101,375 bp
  • G to A, chromosome 11 at 120,006,375 bp
  • C to T, chromosome 13 at 23,684,569 bp
  • C to A, chromosome 13 at 49,688,262 bp
  • A to G, chromosome 14 at 30,896,572 bp
  • A to C, chromosome 14 at 38,371,286 bp
  • G to T, chromosome 14 at 52,172,503 bp
  • A to T, chromosome 15 at 75,597,979 bp
  • C to T, chromosome 15 at 81,685,414 bp
  • T to A, chromosome 18 at 57,879,383 bp
  • T to C, chromosome 19 at 10,478,238 bp
  • C to T, chromosome 19 at 11,183,836 bp
  • G to A, chromosome 19 at 17,466,108 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8797 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068638-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.