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Strain Name:
C57BL/6J-MtgxR8797Btlr/Mmmh
Stock Number:
068638-MU
Citation ID:
RRID:MMRRC_068638-MU
Other Names:
R8797 (G1)
Major Collection:

Strain Information

Baiap2
Name: brain-specific angiogenesis inhibitor 1-associated protein 2
Synonyms: IRSp53
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108100
HGNC: HGNC:947
Homologene: 9697
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214669
Homologene: 12882
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22323
Homologene: 7592
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,123,646 bp
  • C to T, chromosome 1 at 65,071,871 bp
  • T to C, chromosome 1 at 105,750,396 bp
  • T to C, chromosome 1 at 128,303,947 bp
  • T to A, chromosome 1 at 135,974,835 bp
  • C to A, chromosome 1 at 181,637,847 bp
  • A to T, chromosome 2 at 24,397,428 bp
  • A to G, chromosome 2 at 69,220,097 bp
  • T to C, chromosome 2 at 115,864,505 bp
  • A to G, chromosome 2 at 156,875,879 bp
  • G to A, chromosome 2 at 156,875,903 bp
  • T to A, chromosome 2 at 157,229,956 bp
  • G to A, chromosome 3 at 38,999,129 bp
  • C to T, chromosome 3 at 55,045,648 bp
  • T to C, chromosome 4 at 43,706,455 bp
  • T to A, chromosome 4 at 146,535,449 bp
  • A to G, chromosome 5 at 35,029,571 bp
  • G to T, chromosome 5 at 73,635,693 bp
  • A to G, chromosome 7 at 11,670,038 bp
  • T to C, chromosome 7 at 19,260,638 bp
  • A to G, chromosome 7 at 99,483,590 bp
  • C to A, chromosome 7 at 119,538,151 bp
  • A to G, chromosome 7 at 120,640,277 bp
  • A to T, chromosome 8 at 109,648,314 bp
  • T to C, chromosome 8 at 122,408,250 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • T to C, chromosome 9 at 35,478,635 bp
  • A to T, chromosome 9 at 121,790,899 bp
  • C to T, chromosome 10 at 61,271,002 bp
  • T to A, chromosome 10 at 67,224,837 bp
  • A to G, chromosome 10 at 74,584,146 bp
  • T to A, chromosome 10 at 84,697,015 bp
  • T to C, chromosome 10 at 116,777,420 bp
  • T to A, chromosome 10 at 129,767,805 bp
  • T to A, chromosome 11 at 52,145,513 bp
  • T to G, chromosome 11 at 72,778,836 bp
  • T to C, chromosome 11 at 79,475,885 bp
  • C to T, chromosome 11 at 102,676,860 bp
  • T to G, chromosome 11 at 118,101,375 bp
  • G to A, chromosome 11 at 120,006,375 bp
  • C to T, chromosome 13 at 23,684,569 bp
  • C to A, chromosome 13 at 49,688,262 bp
  • A to G, chromosome 14 at 30,896,572 bp
  • A to C, chromosome 14 at 38,371,286 bp
  • G to T, chromosome 14 at 52,172,503 bp
  • A to T, chromosome 15 at 75,597,979 bp
  • C to T, chromosome 15 at 81,685,414 bp
  • T to A, chromosome 18 at 57,879,383 bp
  • T to C, chromosome 19 at 10,478,238 bp
  • C to T, chromosome 19 at 11,183,836 bp
  • G to A, chromosome 19 at 17,466,108 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8797 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068638-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.