Strain Name:
C57BL/6J-MtgxR8910Btlr/Mmmh
Stock Number:
068701-MU
Citation ID:
RRID:MMRRC_068701-MU
Other Names:
R8910 (G1)
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: tn, Hrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Btc
Name: betacellulin, epidermal growth factor family member
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12223
HGNC: HGNC:1121
Homologene: 1309
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: Desrt, 5430435G07Rik, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Zbtb25
Name: zinc finger and BTB domain containing 25
Synonyms: Kup, 2900064P18Rik, Zfp-50, Zfp50, 2810462M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109929
Homologene: 5070
Tex21
Name: testis expressed gene 21
Synonyms: tsec-2, 4931412D23Rik, 4931421K24Rik, 4931406F04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80384
VEGA: 12
Homologene: 10510
Pelp1
Name: proline, glutamic acid and leucine rich protein 1
Synonyms: MNAR, 4930563C04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75273
Homologene: 8664
Ppp4r1
Name: protein phosphatase 4, regulatory subunit 1
Synonyms: Pp4r1, 3110001J10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70351
HGNC: HGNC:9320
Homologene: 81737
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: Tiul1, 8030445B08Rik, AIP5, SDRP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Ezr
Name: ezrin
Synonyms: p81, Vil2, ezrin, cytovillin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22350
Homologene: 55740
Akap12
Name: A kinase anchor protein 12
Synonyms: Tsga12, Srcs5, SSeCKS
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Fermt2
Name: fermitin family member 2
Synonyms: Plekhc1, Mig2, Kindlin-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218952
Homologene: 4976
Tppp3
Name: tubulin polymerization-promoting protein family member 3
Synonyms: 2700055K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67971
Homologene: 32659
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Taf6
Name: TATA-box binding protein associated factor 6
Synonyms: Taf2e, 80kDa, p80
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21343
Homologene: 7561
Wtip
Name: WT1 interacting protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101543
Homologene: 64353
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Unc5a
Name: unc-5 netrin receptor A
Synonyms: Unc5h1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107448
Homologene: 41474
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik, sao
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: 2810423A18Rik, GFAT1, GFAT, GFA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68449
Homologene: 9177
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74111
Homologene: 7158
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104570
Homologene: 68886
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: E330028L06Rik, DPD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Cd244a
Name: CD244 molecule A
Synonyms: Nmrk, F730046O15Rik, Cd244, C9.1, 2B4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18106
Homologene: 9493
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Gm10267
Name: predicted gene 10267
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100042855
Homologene: 104911
Gimap6
Name: GTPase, IMAP family member 6
Synonyms: 4833419H03Rik, Ian6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231931
Homologene: 11670
L3mbtl1
Name: L3MBTL1 histone methyl-lysine binding protein
Synonyms: L3MBTL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241764
Homologene: 41846
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: B930033A02Rik, ABC13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
H2-M2
Name: histocompatibility 2, M region locus 2
Synonyms: Thy19.4, H-2M2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14990
Homologene: 133732
Rad51d
Name: RAD51 paralog D
Synonyms: R51H3, Rad51l3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19364
HGNC: HGNC:9823
Homologene: 2156
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: DFF40, CPAN, CAD, caspase-activated DNase, 40kDa, 5730477D02Rik, Didff
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Cdh15
Name: cadherin 15
Synonyms: M cadherin, Mcad, Cdh14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Cep15
Name: centrosomal protein 15
Synonyms: 3830406C13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218734
VEGA: 14
Homologene: 10787
Or4b1b
Name: olfactory receptor family 4 subfamily B member 1B
Synonyms: Olfr1272, GA_x6K02T2Q125-51636504-51635578, MOR227-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258982
HGNC: HGNC:8290
Homologene: 133649
Slc7a15
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
Synonyms: 2010001P20Rik, Arpat, 9030221C07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328059
Homologene: 77627
Zfp444
Name: zinc finger protein 444
Synonyms: 2810031J10Rik, 6230401O10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72667
Homologene: 10139
Dlgap1
Name: DLG associated protein 1
Synonyms: 4933422O14Rik, GKAP/SAPAP, D17Bwg0511e, SAPAP1, DAP-1 beta, Gkap, Sapap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Cpne4
Name: copine IV
Synonyms: 4933406O10Rik, 3632411M23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74020
HGNC: HGNC:2317
Homologene: 26078
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49f, Ly49F
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16637
Homologene: 110821
Aldh5a1
Name: aldhehyde dehydrogenase family 5, subfamily A1
Synonyms: OTTMUSG00000000613, 6330403E24Rik, D630032B01Rik, SSADH
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214579
HGNC: HGNC:408
Homologene: 840
Fst
Name: follistatin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14313
VEGA: 13
HGNC: HGNC:3971
Homologene: 7324
Evx1
Name: even-skipped homeobox 1
Synonyms: Evx-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14028
HGNC: HGNC:3506
Homologene: 1507
Thap4
Name: THAP domain containing 4
Synonyms: 2010320B01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67026
Homologene: 12075
Fabp6
Name: fatty acid binding protein 6
Synonyms: I-BABP, Illbp, ILBP3, I-15P, gastrotropin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16204
HGNC: HGNC:3561
Homologene: 1108
Fam78a
Name: family with sequence similarity 78, member A
Synonyms: A130092J06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241303
Homologene: 14115
Zkscan14
Name: zinc finger with KRAB and SCAN domains 14
Synonyms: 2310046C23Rik, 2810437E14Rik, Zfp99
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67235
Homologene: 11342
Cept1
Name: choline/ethanolaminephosphotransferase 1
Synonyms: 9930118K05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99712
Homologene: 81624
Larp6
Name: La ribonucleoprotein 6, translational regulator
Synonyms: acheron, Achn, 5430431G03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67557
Homologene: 32408
Anxa2r1
Name: annexin A2 receptor 1
Synonyms: Gm21188
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100861753
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,714,944 bp
  • C to A, chromosome 1 at 171,559,373 bp
  • A to G, chromosome 2 at 22,574,268 bp
  • G to A, chromosome 2 at 32,069,669 bp
  • T to A, chromosome 2 at 65,508,539 bp
  • C to A, chromosome 2 at 90,296,504 bp
  • A to T, chromosome 2 at 162,970,293 bp
  • A to C, chromosome 3 at 106,539,249 bp
  • A to G, chromosome 3 at 118,610,518 bp
  • A to T, chromosome 4 at 19,627,741 bp
  • C to A, chromosome 4 at 82,950,457 bp
  • T to C, chromosome 4 at 153,972,959 bp
  • A to C, chromosome 5 at 91,360,812 bp
  • T to C, chromosome 5 at 96,567,996 bp
  • T to A, chromosome 5 at 120,133,779 bp
  • T to C, chromosome 5 at 138,184,454 bp
  • A to G, chromosome 5 at 145,195,380 bp
  • T to C, chromosome 6 at 23,344,224 bp
  • A to G, chromosome 6 at 48,702,454 bp
  • C to T, chromosome 6 at 52,316,761 bp
  • T to C, chromosome 6 at 87,053,805 bp
  • T to C, chromosome 6 at 106,655,536 bp
  • C to A, chromosome 6 at 116,412,549 bp
  • T to C, chromosome 6 at 130,016,684 bp
  • T to C, chromosome 7 at 6,184,027 bp
  • A to G, chromosome 7 at 29,071,915 bp
  • G to A, chromosome 7 at 34,132,638 bp
  • A to C, chromosome 7 at 105,683,697 bp
  • T to C, chromosome 7 at 127,207,766 bp
  • A to G, chromosome 8 at 105,468,292 bp
  • T to C, chromosome 8 at 122,848,501 bp
  • A to G, chromosome 9 at 60,713,243 bp
  • A to G, chromosome 9 at 104,922,507 bp
  • A to T, chromosome 10 at 4,313,822 bp
  • T to C, chromosome 10 at 28,492,997 bp
  • A to G, chromosome 10 at 68,098,278 bp
  • T to C, chromosome 11 at 6,518,009 bp
  • G to T, chromosome 11 at 29,196,290 bp
  • C to T, chromosome 11 at 43,601,508 bp
  • A to T, chromosome 11 at 70,396,635 bp
  • T to C, chromosome 11 at 82,882,967 bp
  • T to C, chromosome 11 at 110,298,204 bp
  • A to G, chromosome 11 at 115,797,426 bp
  • T to C, chromosome 11 at 120,478,376 bp
  • T to A, chromosome 12 at 8,539,117 bp
  • C to T, chromosome 12 at 76,216,759 bp
  • A to C, chromosome 12 at 76,349,134 bp
  • A to G, chromosome 13 at 24,918,616 bp
  • A to G, chromosome 13 at 37,948,765 bp
  • A to G, chromosome 13 at 55,003,588 bp
  • A to G, chromosome 13 at 77,323,649 bp
  • T to A, chromosome 13 at 114,453,709 bp
  • T to A, chromosome 13 at 120,046,820 bp
  • A to G, chromosome 14 at 12,285,444 bp
  • G to A, chromosome 14 at 45,464,932 bp
  • A to G, chromosome 15 at 4,931,373 bp
  • C to T, chromosome 15 at 76,002,995 bp
  • A to G, chromosome 17 at 6,755,900 bp
  • G to A, chromosome 17 at 37,481,522 bp
  • T to C, chromosome 17 at 65,837,773 bp
  • C to T, chromosome 17 at 70,786,820 bp
  • T to C, chromosome 18 at 13,844,176 bp
  • T to A, chromosome 18 at 44,156,444 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068701-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.