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Strain Name:
C57BL/6J-MtgxR8910Btlr/Mmmh
Stock Number:
068701-MU
Citation ID:
RRID:MMRRC_068701-MU
Other Names:
R8910 (G1)
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: Hrs, tn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Btc
Name: betacellulin, epidermal growth factor family member
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12223
HGNC: HGNC:1121
Homologene: 1309
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Zbtb25
Name: zinc finger and BTB domain containing 25
Synonyms: Zfp-50, Kup, 2810462M08Rik, Zfp50, 2900064P18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109929
Homologene: 5070
Tex21
Name: testis expressed gene 21
Synonyms: tsec-2, 4931412D23Rik, 4931406F04Rik, 4931421K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80384
VEGA: 12
Homologene: 10510
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,714,944 bp
  • C to A, chromosome 1 at 171,559,373 bp
  • A to G, chromosome 2 at 22,574,268 bp
  • G to A, chromosome 2 at 32,069,669 bp
  • T to A, chromosome 2 at 65,508,539 bp
  • C to A, chromosome 2 at 90,296,504 bp
  • A to T, chromosome 2 at 162,970,293 bp
  • A to C, chromosome 3 at 106,539,249 bp
  • A to G, chromosome 3 at 118,610,518 bp
  • A to T, chromosome 4 at 19,627,741 bp
  • C to A, chromosome 4 at 82,950,457 bp
  • T to C, chromosome 4 at 153,972,959 bp
  • A to C, chromosome 5 at 91,360,812 bp
  • T to C, chromosome 5 at 96,567,996 bp
  • T to A, chromosome 5 at 120,133,779 bp
  • T to C, chromosome 5 at 138,184,454 bp
  • A to G, chromosome 5 at 145,195,380 bp
  • T to C, chromosome 6 at 23,344,224 bp
  • A to G, chromosome 6 at 48,702,454 bp
  • C to T, chromosome 6 at 52,316,761 bp
  • T to C, chromosome 6 at 87,053,805 bp
  • T to C, chromosome 6 at 106,655,536 bp
  • C to A, chromosome 6 at 116,412,549 bp
  • T to C, chromosome 6 at 130,016,684 bp
  • T to C, chromosome 7 at 6,184,027 bp
  • A to G, chromosome 7 at 29,071,915 bp
  • G to A, chromosome 7 at 34,132,638 bp
  • A to C, chromosome 7 at 105,683,697 bp
  • T to C, chromosome 7 at 127,207,766 bp
  • A to G, chromosome 8 at 105,468,292 bp
  • T to C, chromosome 8 at 122,848,501 bp
  • A to G, chromosome 9 at 60,713,243 bp
  • A to G, chromosome 9 at 104,922,507 bp
  • A to T, chromosome 10 at 4,313,822 bp
  • T to C, chromosome 10 at 28,492,997 bp
  • A to G, chromosome 10 at 68,098,278 bp
  • T to C, chromosome 11 at 6,518,009 bp
  • G to T, chromosome 11 at 29,196,290 bp
  • C to T, chromosome 11 at 43,601,508 bp
  • A to T, chromosome 11 at 70,396,635 bp
  • T to C, chromosome 11 at 82,882,967 bp
  • T to C, chromosome 11 at 110,298,204 bp
  • A to G, chromosome 11 at 115,797,426 bp
  • T to C, chromosome 11 at 120,478,376 bp
  • T to A, chromosome 12 at 8,539,117 bp
  • C to T, chromosome 12 at 76,216,759 bp
  • A to C, chromosome 12 at 76,349,134 bp
  • A to G, chromosome 13 at 24,918,616 bp
  • A to G, chromosome 13 at 37,948,765 bp
  • A to G, chromosome 13 at 55,003,588 bp
  • A to G, chromosome 13 at 77,323,649 bp
  • T to A, chromosome 13 at 114,453,709 bp
  • T to A, chromosome 13 at 120,046,820 bp
  • A to G, chromosome 14 at 12,285,444 bp
  • G to A, chromosome 14 at 45,464,932 bp
  • A to G, chromosome 15 at 4,931,373 bp
  • C to T, chromosome 15 at 76,002,995 bp
  • A to G, chromosome 17 at 6,755,900 bp
  • G to A, chromosome 17 at 37,481,522 bp
  • T to C, chromosome 17 at 65,837,773 bp
  • C to T, chromosome 17 at 70,786,820 bp
  • T to C, chromosome 18 at 13,844,176 bp
  • T to A, chromosome 18 at 44,156,444 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068701-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.