Strain Name:
C57BL/6J-MtgxR8858Btlr/Mmmh
Stock Number:
068738-MU
Citation ID:
RRID:MMRRC_068738-MU
Other Names:
R8858 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: 9630007J19Rik, Myo5, MyoVA, Dbv, flail, MVa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C030017F07Rik, C130076O07Rik, Bravo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: D17Rp17e, Mekk4, T-associated sex reversal, D17Rp17, MTK1, MAPKKK4, RP17, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Dnajc17
Name: DnaJ heat shock protein family (Hsp40) member C17
Synonyms: D9Bwg1371e, 1700025B16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69408
Homologene: 49527
Orc2
Name: origin recognition complex, subunit 2
Synonyms: Orc2l
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18393
HGNC: HGNC:8488
Homologene: 4512
Unc13d
Name: unc-13 homolog D
Synonyms: Jinx, 2610108D09Rik, Munc13-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70450
Homologene: 26714
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: hsp-E7I, HSP110, hsp110/105, Hsp105
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15505
Homologene: 21322
Gsdma3
Name: gasdermin A3
Synonyms: Rim3, Dfl, Fgn, Gsdm1l, Bsk, Rco2, Gsdm3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 450219
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: ST8SiaV, Siat8e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225742
Homologene: 8331
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329252
Homologene: 49680
Arl6ip6
Name: ADP-ribosylation factor-like 6 interacting protein 6
Synonyms: 2610529A11Rik, 2310057C01Rik, Aip-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65103
Homologene: 11302
Vasn
Name: vasorin
Synonyms: Slitl2, ATIA, 2610528G05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246154
Homologene: 36929
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: B56/PP2A gamma, 2610043M05Rik, D12Bwg0916e, Band 8A, 2700063L20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11982
Homologene: 56461
Rnase9
Name: ribonuclease, RNase A family, 9 (non-active)
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328401
VEGA: 14
Homologene: 18830
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434377
Homologene: 103820
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: 4832426G23Rik, Myhs-p, Myhsp, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 207792
Homologene: 19490
Or2aj6
Name: olfactory receptor family 2 subfamily AJ member 6
Synonyms: MOR273-5, GA_x54KRFPKG5P-16071018-16070077, MOR273-1, Olfr171
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258960
Homologene: 128058
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404195
VEGA: 19
Homologene: 137231
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: A130097D21Rik, enterokinase, enteropeptidase, Prss7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Nfic
Name: nuclear factor I/C
Synonyms: nuclear factor 1-C2, NF1-C, 1500041O16Rik, 1110019L22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18029
HGNC: HGNC:7786
Homologene: 4088
Gadl1
Name: glutamate decarboxylase-like 1
Synonyms: 1110027M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73748
Homologene: 45812
A430033K04Rik
Name: RIKEN cDNA A430033K04 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243308
Homologene: 65621
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Or4f54
Name: olfactory receptor family 4 subfamily F member 54
Synonyms: GA_x6K02T2Q125-72343713-72344654, MOR245-11, Olfr1278
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258389
Homologene: 74061
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: RPTPlambda, Ptprl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Mex3d
Name: mex3 RNA binding family member D
Synonyms: Rkhd1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237400
Homologene: 16890
Zfp672
Name: zinc finger protein 672
Synonyms: 4930488P06Rik, 4930511N19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319475
Homologene: 23493
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Spata31e4
Name: spermatogenesis associated 31 subfamily E member 4
Synonyms: Gm8765
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 667693
Homologene: 134512
Wdr77
Name: WD repeat domain 77
Synonyms: p44/MEP50, 2610312E17Rik, 2610003I18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70465
Homologene: 11466
Lactb
Name: lactamase, beta
Synonyms: Mrpl56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80907
VEGA: 9
Homologene: 12755
Tnfrsf13b
Name: tumor necrosis factor receptor superfamily, member 13b
Synonyms: Taci, 1200009E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57916
Homologene: 49320
Sorbs3
Name: sorbin and SH3 domain containing 3
Synonyms: SH3P3, vinexin alpha, Sh3d4, vinexin beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20410
VEGA: 14
Homologene: 4218
Gbp11
Name: guanylate binding protein 11
Synonyms: Gm7141
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 634650
Homologene: 128731
Ptpn18
Name: protein tyrosine phosphatase, non-receptor type 18
Synonyms: PTP-K1, Ptpk1, HSCF, FLP1, PTP-HSCF
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19253
HGNC: HGNC:9649
Homologene: 74971
Dennd11
Name: DENN domain containing 11
Synonyms: E330009J07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243780
Homologene: 82355
Ciao2a
Name: cytosolic iron-sulfur assembly component 2A
Synonyms: Fam96a, 5730536A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68250
Homologene: 12252
Ighv1-23
Name: immunoglobulin heavy variable V1-23
Synonyms: immunoglobulin heavy variable V1-23, Ighv1-23
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780884
HGNC: HGNC:5553
Gm32742
Name: predicted gene, 32742
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635385
Homologene: 132734
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,463,115 bp
  • A to T, chromosome 1 at 58,493,698 bp
  • T to C, chromosome 1 at 134,996,111 bp
  • A to G, chromosome 1 at 155,226,218 bp
  • T to C, chromosome 2 at 27,228,290 bp
  • T to C, chromosome 2 at 41,670,815 bp
  • A to G, chromosome 2 at 53,203,006 bp
  • G to A, chromosome 2 at 111,293,158 bp
  • T to C, chromosome 2 at 119,180,964 bp
  • C to A, chromosome 2 at 146,260,365 bp
  • T to C, chromosome 3 at 105,961,662 bp
  • T to C, chromosome 4 at 131,799,514 bp
  • T to C, chromosome 4 at 141,939,028 bp
  • C to A, chromosome 5 at 105,325,526 bp
  • A to G, chromosome 5 at 138,640,076 bp
  • A to T, chromosome 5 at 149,625,111 bp
  • T to C, chromosome 6 at 40,422,735 bp
  • A to G, chromosome 7 at 29,109,213 bp
  • A to G, chromosome 7 at 58,816,223 bp
  • G to T, chromosome 7 at 120,453,104 bp
  • A to G, chromosome 8 at 16,070,304 bp
  • A to G, chromosome 8 at 93,987,442 bp
  • A to G, chromosome 8 at 125,251,042 bp
  • T to C, chromosome 9 at 8,130,269 bp
  • A to G, chromosome 9 at 20,349,107 bp
  • T to A, chromosome 9 at 51,150,956 bp
  • T to C, chromosome 9 at 66,132,542 bp
  • G to T, chromosome 9 at 66,955,900 bp
  • T to C, chromosome 9 at 75,184,683 bp
  • A to T, chromosome 9 at 116,006,601 bp
  • A to T, chromosome 10 at 80,381,383 bp
  • A to T, chromosome 10 at 81,427,131 bp
  • G to A, chromosome 11 at 58,317,319 bp
  • A to G, chromosome 11 at 61,147,537 bp
  • A to G, chromosome 11 at 67,301,994 bp
  • C to A, chromosome 11 at 98,629,869 bp
  • G to T, chromosome 11 at 116,062,792 bp
  • T to A, chromosome 12 at 44,597,771 bp
  • T to A, chromosome 12 at 110,552,895 bp
  • T to A, chromosome 12 at 114,764,463 bp
  • T to C, chromosome 13 at 50,701,387 bp
  • G to A, chromosome 14 at 51,039,309 bp
  • T to C, chromosome 14 at 70,201,401 bp
  • A to G, chromosome 16 at 4,648,969 bp
  • A to G, chromosome 16 at 19,624,359 bp
  • A to G, chromosome 16 at 79,057,609 bp
  • A to C, chromosome 17 at 12,271,872 bp
  • C to T, chromosome 18 at 77,232,815 bp
  • G to A, chromosome 19 at 40,073,783 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8858 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068738-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.