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Strain Name:
C57BL/6J-MtgxR8926Btlr/Mmmh
Stock Number:
068770-MU
Citation ID:
RRID:MMRRC_068770-MU
Other Names:
R8926 (G1)
Major Collection:

Strain Information

Prkar2b
Name: protein kinase, cAMP dependent regulatory, type II beta
Synonyms: Pkarb2, RII(beta), PKARIIbeta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19088
HGNC: HGNC:9392
Homologene: 37666
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81897
Homologene: 68126
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Dclre1c
Name: DNA cross-link repair 1C
Synonyms: 9930121L06Rik, Artemis, Art
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227525
Homologene: 32547
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Helz
Name: helicase with zinc finger domain
Synonyms: 9630002H22Rik, 9430093I07Rik, 3110078M01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,089,706 bp
  • A to T, chromosome 1 at 40,580,768 bp
  • G to C, chromosome 1 at 119,526,676 bp
  • T to A, chromosome 1 at 128,300,411 bp
  • C to T, chromosome 1 at 135,386,214 bp
  • C to T, chromosome 1 at 154,701,334 bp
  • T to C, chromosome 1 at 191,760,008 bp
  • A to T, chromosome 2 at 3,433,790 bp
  • C to A, chromosome 2 at 22,396,263 bp
  • T to G, chromosome 2 at 26,911,545 bp
  • T to A, chromosome 2 at 76,741,391 bp
  • T to A, chromosome 2 at 82,993,583 bp
  • G to A, chromosome 2 at 180,193,990 bp
  • T to G, chromosome 3 at 20,069,159 bp
  • T to A, chromosome 3 at 40,653,709 bp
  • A to T, chromosome 3 at 152,427,892 bp
  • T to G, chromosome 4 at 53,686,493 bp
  • T to A, chromosome 5 at 30,200,448 bp
  • T to C, chromosome 5 at 34,129,425 bp
  • T to A, chromosome 5 at 136,309,550 bp
  • C to T, chromosome 5 at 144,216,962 bp
  • T to G, chromosome 5 at 149,201,891 bp
  • C to T, chromosome 6 at 18,268,004 bp
  • A to T, chromosome 6 at 30,374,888 bp
  • A to G, chromosome 6 at 71,892,480 bp
  • A to G, chromosome 6 at 87,749,187 bp
  • C to A, chromosome 6 at 91,053,452 bp
  • C to T, chromosome 6 at 124,533,366 bp
  • T to C, chromosome 6 at 124,536,363 bp
  • A to G, chromosome 6 at 147,019,488 bp
  • A to G, chromosome 7 at 16,134,269 bp
  • A to T, chromosome 7 at 20,787,949 bp
  • G to A, chromosome 7 at 25,713,069 bp
  • G to A, chromosome 7 at 28,154,444 bp
  • G to A, chromosome 7 at 108,066,306 bp
  • A to T, chromosome 7 at 116,156,988 bp
  • A to T, chromosome 7 at 129,321,487 bp
  • G to A, chromosome 7 at 140,652,200 bp
  • A to G, chromosome 8 at 93,025,213 bp
  • T to G, chromosome 8 at 111,537,511 bp
  • A to T, chromosome 9 at 35,235,436 bp
  • T to C, chromosome 9 at 57,681,078 bp
  • T to A, chromosome 9 at 65,437,132 bp
  • T to A, chromosome 9 at 71,725,253 bp
  • A to T, chromosome 9 at 106,226,014 bp
  • T to A, chromosome 9 at 113,685,425 bp
  • C to T, chromosome 10 at 14,716,691 bp
  • T to C, chromosome 10 at 21,055,083 bp
  • T to G, chromosome 10 at 23,900,689 bp
  • C to T, chromosome 10 at 127,545,802 bp
  • C to A, chromosome 11 at 83,990,741 bp
  • G to T, chromosome 11 at 104,585,746 bp
  • T to G, chromosome 11 at 106,568,404 bp
  • C to A, chromosome 11 at 107,672,683 bp
  • C to A, chromosome 12 at 17,416,870 bp
  • A to G, chromosome 12 at 32,061,081 bp
  • G to A, chromosome 12 at 105,218,710 bp
  • T to A, chromosome 13 at 60,760,920 bp
  • T to C, chromosome 13 at 109,938,091 bp
  • C to A, chromosome 14 at 45,169,314 bp
  • A to G, chromosome 14 at 49,187,602 bp
  • A to G, chromosome 14 at 54,985,076 bp
  • T to A, chromosome 15 at 74,839,238 bp
  • C to T, chromosome 15 at 78,340,549 bp
  • C to T, chromosome 16 at 17,899,698 bp
  • T to A, chromosome 16 at 59,839,299 bp
  • T to A, chromosome 17 at 17,838,528 bp
  • T to A, chromosome 17 at 36,109,734 bp
  • C to A, chromosome 18 at 69,996,073 bp
  • T to C, chromosome 19 at 8,847,984 bp
  • C to A, chromosome 19 at 50,252,658 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8926 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068770-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.