Strain Name:
C57BL/6J-MtgxR8976Btlr/Mmmh
Stock Number:
068810-MU
Citation ID:
RRID:MMRRC_068810-MU
Other Names:
R8976 (G1)
Major Collection:

Strain Information

Olig2
Name: oligodendrocyte transcription factor 2
Synonyms: RK17, Olg-2, Bhlhb1, bHLHe19
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50913
HGNC: HGNC:9398
Homologene: 4241
Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Ssbp4
Name: single stranded DNA binding protein 4
Synonyms: 1210002E11Rik, Ssdp4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76900
Homologene: 41881
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Ski
Name: ski sarcoma viral oncogene homolog (avian)
Synonyms: 2610001A11Rik, 2310012I02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20481
Homologene: 31124
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Trim23
Name: tripartite motif-containing 23
Synonyms: Arfd1, 6330516O20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 81003
HGNC: HGNC:660
Homologene: 1251
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, TFIIIB90, TAF3B1, TFC5, Tfnr, G630013P12Rik, B130055N23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, Astrin, s17, S17, Mastrin, Deepest, D11Bhm180e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: ZF5, Zfp161, b2b1982Clo
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22666
Homologene: 2560
Slc49a3
Name: solute carrier family 49 member 3
Synonyms: 4732482E20Rik, Mfsd7, Mfsd7a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243197
VEGA: 5
Homologene: 49990
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: 1110014E10Rik, D530031C13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Ska3
Name: spindle and kinetochore associated complex subunit 3
Synonyms: F630043A04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219114
VEGA: 14
Homologene: 124284
Iqcb1
Name: IQ calmodulin-binding motif containing 1
Synonyms: 6820449I09Rik, NPHP5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320299
Homologene: 8766
F2
Name: coagulation factor II
Synonyms: prothrombin, Cf-2, Cf2, FII, thrombin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14061
HGNC: HGNC:3535
Homologene: 426
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Ulk3
Name: unc-51-like kinase 3
Synonyms: 1200015E14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71742
VEGA: 9
Homologene: 68482
Cyp2j9
Name: cytochrome P450, family 2, subfamily j, polypeptide 9
Synonyms: 8430417E17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74519
HGNC: HGNC:2634
Homologene: 137388
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22307
Homologene: 129606
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
F12
Name: coagulation factor XII (Hageman factor)
Synonyms: FXII
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 58992
HGNC: HGNC:3530
Homologene: 425
Dnm3
Name: dynamin 3
Synonyms: B230343F03Rik, 9630020E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66898
Homologene: 23123
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217219
Homologene: 19144
Odad3
Name: outer dynein arm docking complex subunit 3
Synonyms: Ccdc151, C330001K17Rik, b2b1885Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77609
VEGA: 9
Homologene: 16533
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Pus1
Name: pseudouridine synthase 1
Synonyms: MPUS1, mPus1p, A730013B20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56361
Homologene: 5931
Mybphl
Name: myosin binding protein H-like
Synonyms: 1110037P11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68753
Homologene: 19221
Or5p73
Name: olfactory receptor family 5 subfamily P member 73
Synonyms: GA_x6K02T2PBJ9-10795522-10796514, MOR204-36, Olfr498
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258304
Homologene: 133600
Or7a38
Name: olfactory receptor family 7 subfamily A member 38
Synonyms: GA_x6K02T03FR9-4826-3919, GA_x6K02T2QGN0-2895081-2894349, MOR185-8, MOR139-7, MOR139-5, EG257869, Olfr233-ps1, Olfr1354
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259163
Homologene: 136441
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Frs3
Name: fibroblast growth factor receptor substrate 3
Synonyms: SNT2, Frs2beta, 4930417B13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 107971
Homologene: 4845
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171200
Homologene: 134034
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231999
Homologene: 32284
Lrrc8d
Name: leucine rich repeat containing 8D
Synonyms: 4930525N13Rik, Lrrc5, 2810473G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231549
Homologene: 10004
Tigd3
Name: tigger transposable element derived 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 332359
VEGA: 19
Homologene: 129795
Or6f2
Name: olfactory receptor family 6 subfamily F member 2
Synonyms: GA_x6K02T2PBJ9-42327937-42328872, MOR104-4, Olfr523
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258511
Homologene: 27191
Or10a4
Name: olfactory receptor family 10 subfamily A member 4
Synonyms: P2, MOR263-5, GA_x6K02T2PBJ9-9470146-9471093, Olfr17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18314
Homologene: 23241
Srl
Name: sarcalumenin
Synonyms: sarcalumenin, sar, 9830004M20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106393
Homologene: 45500
Spa17
Name: sperm autoantigenic protein 17
Synonyms: band 34, Sp17
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20686
VEGA: 9
Homologene: 7951
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: CD122, Il-2Rbeta, IL15Rbeta, IL-2/15Rbeta, IL-15 receptor beta chain, IL-15Rbeta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Ifnlr1
Name: interferon lambda receptor 1
Synonyms: IFNLR1, CRF2-12, Il28ra
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242700
Homologene: 52086
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: E330012B09Rik, Gcap8, Galnt19, Wbscr17
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212996
Homologene: 49707
Keap1
Name: kelch-like ECH-associated protein 1
Synonyms: ring canal protein, INrf2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50868
Homologene: 8184
Surf1
Name: surfeit gene 1
Synonyms: Surf-1, 0610010F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20930
Homologene: 2387
Tmem176b
Name: transmembrane protein 176B
Synonyms: Clast1, Lr8, 1810009M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65963
Homologene: 8521
Or7g22
Name: olfactory receptor family 7 subfamily G member 22
Synonyms: GA_x6K02T2PVTD-12873838-12874776, MOR152-2, Olfr837
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258558
HGNC: HGNC:8466
Homologene: 115507
Prr18
Name: proline rich 18
Synonyms: 9630019K15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320111
VEGA: 17
Homologene: 52195
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,472,010 bp
  • G to A, chromosome 1 at 162,307,936 bp
  • A to T, chromosome 2 at 26,915,755 bp
  • G to A, chromosome 2 at 76,714,766 bp
  • A to G, chromosome 2 at 91,636,393 bp
  • C to T, chromosome 2 at 155,970,122 bp
  • T to C, chromosome 2 at 174,645,286 bp
  • T to A, chromosome 2 at 181,234,693 bp
  • T to A, chromosome 3 at 59,275,908 bp
  • A to C, chromosome 3 at 80,851,056 bp
  • A to G, chromosome 3 at 87,728,014 bp
  • G to A, chromosome 3 at 108,365,018 bp
  • T to C, chromosome 4 at 96,591,162 bp
  • T to A, chromosome 4 at 135,701,339 bp
  • A to G, chromosome 4 at 155,157,954 bp
  • T to A, chromosome 5 at 93,638,118 bp
  • T to A, chromosome 5 at 105,813,091 bp
  • A to C, chromosome 5 at 108,442,031 bp
  • T to A, chromosome 5 at 108,997,613 bp
  • A to G, chromosome 5 at 110,774,923 bp
  • T to G, chromosome 5 at 130,906,705 bp
  • A to T, chromosome 5 at 144,286,307 bp
  • A to G, chromosome 6 at 48,835,666 bp
  • A to T, chromosome 6 at 54,630,536 bp
  • A to G, chromosome 6 at 57,404,734 bp
  • A to T, chromosome 6 at 119,338,157 bp
  • T to C, chromosome 7 at 107,098,259 bp
  • T to A, chromosome 7 at 108,465,423 bp
  • T to C, chromosome 7 at 140,176,972 bp
  • T to C, chromosome 8 at 45,031,295 bp
  • A to T, chromosome 8 at 70,599,686 bp
  • T to A, chromosome 9 at 19,137,845 bp
  • A to C, chromosome 9 at 21,231,367 bp
  • T to A, chromosome 9 at 21,992,038 bp
  • C to T, chromosome 9 at 37,611,958 bp
  • T to A, chromosome 9 at 57,594,937 bp
  • T to A, chromosome 9 at 95,890,766 bp
  • G to A, chromosome 10 at 28,585,673 bp
  • T to C, chromosome 10 at 78,917,584 bp
  • A to G, chromosome 11 at 69,747,211 bp
  • T to C, chromosome 11 at 78,304,587 bp
  • T to C, chromosome 11 at 102,438,625 bp
  • T to A, chromosome 11 at 118,026,840 bp
  • T to A, chromosome 12 at 4,917,923 bp
  • T to A, chromosome 13 at 55,421,964 bp
  • C to A, chromosome 13 at 100,060,899 bp
  • G to T, chromosome 13 at 104,192,037 bp
  • A to T, chromosome 14 at 7,901,882 bp
  • A to T, chromosome 14 at 57,820,394 bp
  • C to T, chromosome 15 at 78,486,481 bp
  • A to G, chromosome 15 at 89,558,178 bp
  • A to T, chromosome 16 at 4,483,030 bp
  • A to G, chromosome 16 at 36,871,643 bp
  • A to G, chromosome 16 at 91,226,475 bp
  • G to T, chromosome 16 at 93,762,081 bp
  • T to C, chromosome 17 at 8,341,215 bp
  • T to C, chromosome 17 at 12,726,772 bp
  • A to T, chromosome 17 at 47,698,621 bp
  • G to A, chromosome 17 at 69,387,757 bp
  • A to G, chromosome 18 at 3,268,088 bp
  • G to A, chromosome 18 at 37,518,343 bp
  • G to A, chromosome 19 at 5,891,825 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8976 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.