Strain Name:
C57BL/6J-MtgxR8994Btlr/Mmmh
Stock Number:
068825-MU
Citation ID:
RRID:MMRRC_068825-MU
Other Names:
R8994 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Med13l
Name: mediator complex subunit 13-like
Synonyms: 9030618F05Rik, Trap240L, Thrap2, 6330591G05Rik, 2210413I17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73274
Homologene: 11292
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75991
Homologene: 18952
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Abcc4
Name: ATP-binding cassette, sub-family C member 4
Synonyms: D630049P08Rik, MRP4, MOAT-B
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Wdr33
Name: WD repeat domain 33
Synonyms: WDC146, 2310011G05Rik, 8430413N20Rik, 2810021O11Rik, 1110001N06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74320
VEGA: 18
Homologene: 56807
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, Gcap14, 2900054P12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, YR-23, D1Bwg0491e, Rw1, Neg, 2610524E03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: Mcmdc1, 9030408O17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Klk12
Name: kallikrein related-peptidase 12
Synonyms: KLK-L5, 2310008B01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69511
HGNC: HGNC:6360
Homologene: 44690
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Nudcd2
Name: NudC domain containing 2
Synonyms: 2700047N05Rik, D11Ertd603e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52653
Homologene: 12094
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68187
Homologene: 32665
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: 1110031M08Rik, Hnrpul2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Timm21
Name: translocase of inner mitochondrial membrane 21
Synonyms: 2700002I20Rik, 1700034H14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67105
VEGA: 18
Homologene: 32211
Rbm48
Name: RNA binding motif protein 48
Synonyms: C030048B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269623
Homologene: 12944
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: IASPP, wa3, NFkB interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Tmem86b
Name: transmembrane protein 86B
Synonyms: C330014O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68255
Homologene: 52159
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Plpp4
Name: phospholipid phosphatase 4
Synonyms: C030048B12Rik, LOC381925, Ppapdc1a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381925
Homologene: 38751
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Kif1a
Name: kinesin family member 1A
Synonyms: ATSV, N-3 kinesin, Kns1, LOC381283, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Prl6a1
Name: prolactin family 6, subfamily a, member 1
Synonyms: PLP-B, Prlpb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19111
Homologene: 49261
Cd300e
Name: CD300E molecule
Synonyms: Trem5, Cd300le, Clm2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217306
Homologene: 18145
Or10p1
Name: olfactory receptor family 10 subfamily P member 1
Synonyms: MOR269-1, Olfr796, GA_x6K02T2PULF-11287099-11286167
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258933
Homologene: 17439
Or5p81
Name: olfactory receptor family 5 subfamily P member 81
Synonyms: Olfr510, MOR204-34, GA_x6K02T2PBJ9-10997715-10998659
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258308
Kcng1
Name: potassium voltage-gated channel, subfamily G, member 1
Synonyms: OTTMUSG00000016048
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241794
HGNC: HGNC:6248
Homologene: 20515
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 434484
Homologene: 128391
Zfp455
Name: zinc finger protein 455
Synonyms: Rslcan-10, 3732412P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218311
Homologene: 110878
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Rigi
Name: RNA sensor RIG-I
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I, Ddx58, 6430573D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, Fars1, 6720478K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: mGK-27, Klk21l, Klk27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16619
Homologene: 68141
Frmd3
Name: FERM domain containing 3
Synonyms: 4.1O, P410, 9430066I12Rik, EPB41L4O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242506
Homologene: 16012
Or51af1
Name: olfactory receptor family 51 subfamily AF member 1
Synonyms: Olfr609, MOR9-1, GA_x6K02T2PBJ9-6207735-6206776
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259086
Homologene: 64952
Or10al7
Name: olfactory receptor family 10 subfamily AL member 7
Synonyms: GA_x6K02T2PSCP-2503741-2502776, Olfr129, MOR263-9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258324
Homologene: 133641
Garin5a
Name: golgi associated RAB2 interactor 5A
Synonyms: 1700021P22Rik, 1700021N13Rik, Fam71e1, 0610007G24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75538
Homologene: 19259
Fpr3
Name: formyl peptide receptor 3
Synonyms: Lxa4r, Fprl1, Fpr-rs1, LXA4-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14294
Fam174a
Name: family with sequence similarity 174, member A
Synonyms: 2310044D20Rik, Tmem157
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67698
Homologene: 12175
Or8c19-ps1
Name: olfactory receptor family 8 subfamily C member 19, pseudogene1
Synonyms: MOR170-7, Olfr897-ps1, GA_x6K02T2PVTD-31999710-32000653
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258473
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,028,540 bp
  • T to C, chromosome 1 at 36,815,457 bp
  • T to A, chromosome 1 at 85,621,882 bp
  • G to A, chromosome 1 at 93,055,735 bp
  • C to A, chromosome 1 at 95,313,964 bp
  • G to T, chromosome 2 at 30,407,875 bp
  • C to T, chromosome 2 at 168,268,848 bp
  • A to T, chromosome 3 at 126,929,822 bp
  • C to A, chromosome 4 at 40,205,941 bp
  • T to C, chromosome 4 at 74,170,748 bp
  • T to C, chromosome 4 at 149,195,482 bp
  • T to A, chromosome 5 at 3,590,795 bp
  • T to A, chromosome 5 at 72,957,641 bp
  • A to C, chromosome 5 at 118,728,161 bp
  • T to A, chromosome 5 at 121,303,566 bp
  • A to G, chromosome 6 at 58,874,343 bp
  • C to A, chromosome 6 at 134,541,693 bp
  • A to G, chromosome 7 at 4,629,707 bp
  • G to T, chromosome 7 at 19,368,770 bp
  • A to C, chromosome 7 at 24,126,065 bp
  • A to T, chromosome 7 at 43,772,061 bp
  • A to G, chromosome 7 at 44,055,712 bp
  • G to T, chromosome 7 at 44,496,918 bp
  • A to T, chromosome 7 at 103,492,593 bp
  • G to A, chromosome 7 at 108,667,962 bp
  • A to G, chromosome 7 at 129,379,433 bp
  • T to C, chromosome 8 at 122,483,090 bp
  • A to T, chromosome 9 at 38,309,285 bp
  • T to C, chromosome 10 at 53,548,524 bp
  • C to A, chromosome 10 at 58,480,069 bp
  • A to T, chromosome 10 at 129,608,136 bp
  • A to G, chromosome 11 at 40,734,035 bp
  • A to T, chromosome 11 at 115,055,522 bp
  • A to T, chromosome 12 at 17,352,716 bp
  • A to G, chromosome 13 at 27,315,434 bp
  • T to A, chromosome 13 at 36,204,866 bp
  • T to C, chromosome 13 at 64,062,881 bp
  • T to C, chromosome 13 at 67,207,414 bp
  • GTT to GT, chromosome 13 at 81,405,338 bp
  • C to A, chromosome 13 at 111,466,850 bp
  • A to T, chromosome 14 at 36,940,119 bp
  • A to C, chromosome 14 at 111,680,795 bp
  • T to A, chromosome 14 at 118,534,144 bp
  • T to C, chromosome 15 at 8,143,161 bp
  • T to C, chromosome 15 at 44,547,103 bp
  • T to A, chromosome 15 at 89,533,213 bp
  • T to A, chromosome 17 at 12,716,650 bp
  • T to C, chromosome 17 at 17,971,079 bp
  • T to A, chromosome 17 at 30,790,833 bp
  • T to C, chromosome 17 at 38,055,329 bp
  • T to C, chromosome 18 at 31,827,406 bp
  • A to G, chromosome 18 at 43,310,477 bp
  • T to C, chromosome 18 at 84,951,364 bp
  • T to C, chromosome 19 at 8,824,986 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8994 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068825-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.