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Strain Name:
C57BL/6J-MtgxR9222Btlr/Mmmh
Stock Number:
069058-MU
Citation ID:
RRID:MMRRC_069058-MU
Other Names:
R9222 (G1)
Major Collection:

Strain Information

Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: Rfv-3, CEM15, Rfv3, Gm20117
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 80287
Homologene: 105420
Fkbp9
Name: FK506 binding protein 9
Synonyms: FKBP60, FKBP63
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27055
HGNC: HGNC:3725
Homologene: 31434
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Luc7l2
Name: LUC7-like 2 (S. cerevisiae)
Synonyms: CGI-59, CGI-74, 4930471C18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192196
Homologene: 56737
Plk4
Name: polo like kinase 4
Synonyms: Sak, Stk18
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20873
Homologene: 7962
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: E230024D05Rik, 9030416H16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71521
Homologene: 22877
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Ccdc191
Name: coiled-coil domain containing 191
Synonyms: 2610015P09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212153
Homologene: 19484
Ift80
Name: intraflagellar transport 80
Synonyms: 4921524P20Rik, Wdr56
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68259
Homologene: 12253
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Dpep2
Name: dipeptidase 2
Synonyms: MBD-2, F630103D06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319446
Homologene: 49703
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Tubgcp2
Name: tubulin, gamma complex component 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74237
Homologene: 55980
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: capsaicin receptor, VR-1, OTRPC1, Vr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193034
Homologene: 12920
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: D430036N24Rik, 9830001H06Rik, Soga1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Fbxw9
Name: F-box and WD-40 domain protein 9
Synonyms: 1110017H11Rik, Fbw9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68628
Homologene: 23598
1700123K08Rik
Name: RIKEN cDNA 1700123K08 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76658
Homologene: 86127
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E21Rik, Myospryn, 2310076E16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Chn1
Name: chimerin 1
Synonyms: 1700112L09Rik, 0710001E19Rik, ARHGAP2, 2900046J01Rik, 0610007I19Rik, alpha1 chimaerin, alpha2 chimaerin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108699
HGNC: HGNC:1943
Homologene: 31056
Slc1a1
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms: MEAAC1, EAAC1, EAAT3, D130048G10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20510
Homologene: 20881
Tbx19
Name: T-box 19
Synonyms: Tpit, D1Ertd754e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83993
Homologene: 3779
Tmem209
Name: transmembrane protein 209
Synonyms: 2700094F01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72649
Homologene: 18021
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Tsbp1
Name: testis expressed basic protein 1
Synonyms: BC051142
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407788
Homologene: 128168
Cryz
Name: crystallin, zeta
Synonyms: quinone reductase, SEZ9, Sez9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12972
HGNC: HGNC:2419
Homologene: 133907
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70918
Homologene: 11653
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83561
Homologene: 12850
Sec11a
Name: SEC11 homolog A, signal peptidase complex subunit
Synonyms: sid2895, 18kDa, 1810012E07Rik, Spc18, Sec11l1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56529
Homologene: 55536
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-a, Slp2, Slp2-d, Slp2-c, Slp2-b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83671
Homologene: 131343
Acte1
Name: actin, epsilon 1
Synonyms: LOC244239, Gm498
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545481
Homologene: 53500
Slc15a5
Name: solute carrier family 15, member 5
Synonyms: 9830102E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 277898
Homologene: 65333
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Dmac2l
Name: distal membrane arm assembly component 2 like
Synonyms: facyor B, 1110015E18Rik, Atp5s
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68055
VEGA: 12
Homologene: 12232
Nfkbiz
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Synonyms: Mail
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80859
Homologene: 12734
Fbxw17
Name: F-box and WD-40 domain protein 17
Synonyms: 1110064L07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109082
Homologene: 82571
Rsph6a
Name: radial spoke head 6 homolog A (Chlamydomonas)
Synonyms: RSP4, Rshl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83434
Homologene: 36476
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Or4b13
Name: olfactory receptor family 4 subfamily B member 13
Synonyms: K20, MOR227-2, GA_x6K02T2Q125-51607674-51606757, Olfr142
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 406186
HGNC: HGNC:8290
Homologene: 45081
Actr5
Name: ARP5 actin-related protein 5
Synonyms: B430109J19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109275
Homologene: 6818
Gstm5
Name: glutathione S-transferase, mu 5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14866
HGNC: HGNC:4635
Homologene: 658
Vmn1r11
Name: vomeronasal 1 receptor 11
Synonyms: V1rc3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113860
Homologene: 128345
Mosmo
Name: modulator of smoothened
Synonyms: BC030336
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233812
Homologene: 16600
Taar7d
Name: trace amine-associated receptor 7D
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 435206
Homologene: 115653
Fut7
Name: fucosyltransferase 7
Synonyms: Fuc-TVII, FTVII, FucT-VII
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14347
HGNC: HGNC:4018
Homologene: 3296
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23801
Homologene: 8013
Oog1
Name: oogenesin 1
Synonyms: c-1, Oog
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 193322
VEGA: 12
Homologene: 103830
Hspb9
Name: heat shock protein, alpha-crystallin-related, B9
Synonyms: 1700007H20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75482
Homologene: 50045
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 153,243,341 bp (GRCm38)
  • C to A, chromosome 1 at 165,139,040 bp (GRCm38)
  • T to C, chromosome 2 at 25,425,179 bp (GRCm38)
  • T to A, chromosome 2 at 73,613,155 bp (GRCm38)
  • C to T, chromosome 2 at 82,985,614 bp (GRCm38)
  • C to T, chromosome 2 at 90,252,476 bp (GRCm38)
  • A to G, chromosome 2 at 131,520,923 bp (GRCm38)
  • A to G, chromosome 2 at 157,039,999 bp (GRCm38)
  • T to C, chromosome 2 at 158,546,772 bp (GRCm38)
  • T to A, chromosome 2 at 158,631,503 bp (GRCm38)
  • T to C, chromosome 2 at 161,560,186 bp (GRCm38)
  • T to A, chromosome 3 at 40,806,555 bp (GRCm38)
  • AC to A, chromosome 3 at 56,090,972 bp (GRCm38)
  • A to G, chromosome 3 at 68,918,561 bp (GRCm38)
  • A to G, chromosome 3 at 107,897,318 bp (GRCm38)
  • T to C, chromosome 3 at 154,611,566 bp (GRCm38)
  • C to T, chromosome 5 at 30,921,797 bp (GRCm38)
  • A to T, chromosome 5 at 37,320,306 bp (GRCm38)
  • T to A, chromosome 5 at 62,671,078 bp (GRCm38)
  • G to A, chromosome 5 at 65,647,938 bp (GRCm38)
  • T to C, chromosome 5 at 66,261,023 bp (GRCm38)
  • G to A, chromosome 5 at 96,657,228 bp (GRCm38)
  • A to G, chromosome 5 at 137,467,201 bp (GRCm38)
  • C to A, chromosome 5 at 138,562,300 bp (GRCm38)
  • G to A, chromosome 6 at 30,506,839 bp (GRCm38)
  • A to T, chromosome 6 at 38,565,698 bp (GRCm38)
  • G to T, chromosome 6 at 56,875,692 bp (GRCm38)
  • A to G, chromosome 6 at 57,138,007 bp (GRCm38)
  • C to G, chromosome 6 at 116,043,088 bp (GRCm38)
  • A to G, chromosome 6 at 137,984,452 bp (GRCm38)
  • A to G, chromosome 6 at 141,492,178 bp (GRCm38)
  • A to G, chromosome 7 at 16,843,774 bp (GRCm38)
  • C to A, chromosome 7 at 19,068,061 bp (GRCm38)
  • G to A, chromosome 7 at 80,915,886 bp (GRCm38)
  • A to G, chromosome 7 at 90,401,425 bp (GRCm38)
  • T to A, chromosome 7 at 120,677,832 bp (GRCm38)
  • T to A, chromosome 7 at 130,626,255 bp (GRCm38)
  • T to C, chromosome 7 at 140,008,052 bp (GRCm38)
  • G to T, chromosome 7 at 143,881,165 bp (GRCm38)
  • T to A, chromosome 8 at 85,062,227 bp (GRCm38)
  • T to A, chromosome 8 at 105,996,384 bp (GRCm38)
  • A to T, chromosome 8 at 128,799,129 bp (GRCm38)
  • A to T, chromosome 9 at 119,781,947 bp (GRCm38)
  • A to C, chromosome 10 at 24,028,226 bp (GRCm38)
  • A to G, chromosome 11 at 69,133,077 bp (GRCm38)
  • T to C, chromosome 11 at 73,250,855 bp (GRCm38)
  • A to G, chromosome 11 at 100,713,943 bp (GRCm38)
  • T to C, chromosome 12 at 69,741,780 bp (GRCm38)
  • A to G, chromosome 12 at 87,606,246 bp (GRCm38)
  • T to A, chromosome 13 at 50,423,331 bp (GRCm38)
  • T to C, chromosome 13 at 93,094,071 bp (GRCm38)
  • A to G, chromosome 15 at 79,899,069 bp (GRCm38)
  • A to G, chromosome 15 at 85,931,270 bp (GRCm38)
  • A to T, chromosome 15 at 98,849,443 bp (GRCm38)
  • A to G, chromosome 16 at 17,358,361 bp (GRCm38)
  • C to T, chromosome 16 at 20,502,632 bp (GRCm38)
  • A to T, chromosome 16 at 29,314,654 bp (GRCm38)
  • T to A, chromosome 16 at 43,905,468 bp (GRCm38)
  • A to T, chromosome 16 at 55,813,984 bp (GRCm38)
  • A to T, chromosome 17 at 34,429,948 bp (GRCm38)
  • A to G, chromosome 17 at 43,628,340 bp (GRCm38)
  • T to C, chromosome 18 at 67,434,187 bp (GRCm38)
  • A to G, chromosome 19 at 28,905,394 bp (GRCm38)
  • G to T, chromosome 19 at 56,843,247 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9222 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069058-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.