Strain Name:
C57BL/6J-MtgxR9593Btlr/Mmmh
Stock Number:
069386-MU
Citation ID:
RRID:MMRRC_069386-MU
Other Names:
R9593 (G1)
Major Collection:

Strain Information

Traf4
Name: TNF receptor associated factor 4
Synonyms: msp2, A530032M13Rik, CART1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22032
Homologene: 3173
Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Zfp710
Name: zinc finger protein 710
Synonyms: 5430400N05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209225
Homologene: 19625
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Rnd1
Name: Rho family GTPase 1
Synonyms: A830014L09Rik, Arhs
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223881
Homologene: 8706
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: Psa, MP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27054
Homologene: 74571
B3galt2
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26878
HGNC: HGNC:917
Homologene: 74512
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: A530025K05Rik, Acac, Acc1, LOC327983, acetyl-CoA carboxylase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: Nip3L, Nix, D14Ertd719e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Mpp3
Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms: Dlgh3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13384
HGNC: HGNC:7221
Homologene: 31065
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217653
Homologene: 10147
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: CED-5, MBC, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Gnb1l
Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Synonyms: ESTM55, Wdvcf, Wdr14, Me49f07
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13972
HGNC: HGNC:4397
Homologene: 41515
Cat
Name: catalase
Synonyms: Cas1, Cs-1, Cas-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
Synonyms: C630048P16Rik, Gabra-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14395
HGNC: HGNC:4076
Homologene: 20217
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Pear1
Name: platelet endothelial aggregation receptor 1
Synonyms: Jedi-1, 3110045G13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73182
Homologene: 12492
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 2610018O07Rik, 8430417G19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 114615
Homologene: 10272
Maz
Name: MYC-associated zinc finger protein (purine-binding transcription factor)
Synonyms: SAF-2, PUR1, Pur-1, SAF-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17188
HGNC: HGNC:6914
Homologene: 106451
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329421
Homologene: 51393
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Ankrd24
Name: ankyrin repeat domain 24
Synonyms: 4631433D01Rik, 5730519E19Rik, D10Bur2e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70615
Homologene: 49885
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Mtrf1
Name: mitochondrial translational release factor 1
Synonyms: A830062K05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211253
VEGA: 14
HGNC: HGNC:7469
Homologene: 20903
St3gal6
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Synonyms: ST3Gal VI, 1700023B24Rik, Siat10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54613
Homologene: 4448
Tyms
Name: thymidylate synthase
Synonyms: TS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22171
Homologene: 834
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52372
Dusp10
Name: dual specificity phosphatase 10
Synonyms: 2610306G15Rik, MKP5, MKP-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63953
HGNC: HGNC:3065
Homologene: 5215
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp4e, 4930406H16Rik, Nalp-epsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Or8c16
Name: olfactory receptor family 8 subfamily C member 16
Synonyms: GA_x6K02T2PVTD-31898993-31899934, Olfr894, MOR170-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258868
Sox13
Name: SRY (sex determining region Y)-box 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20668
Homologene: 4159
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Entrep3
Name: endosomal transmembrane epsin interactor 3
Synonyms: Fam189b, 1110013L07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68521
HGNC: HGNC:1233
Homologene: 4805
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22157
Homologene: 2491
Plekhg2
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms: Clg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101497
Homologene: 16341
Fdx2
Name: ferredoxin 2
Synonyms: B230118G17Rik, Fdx1l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68165
VEGA: 9
Homologene: 31955
Aipl1
Name: aryl hydrocarbon receptor-interacting protein-like 1
Synonyms: A930007I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114230
HGNC: HGNC:359
Homologene: 22806
A130010J15Rik
Name: RIKEN cDNA A130010J15 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319266
Homologene: 17592
Pcdha4
Name: protocadherin alpha 4
Synonyms: Crnr1, Cnr1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12936
HGNC: HGNC:8670
Homologene: 130626
Slfn14
Name: schlafen 14
Synonyms: LOC237890, Slfn14-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237890
Homologene: 19082
Inafm1
Name: InaF motif containing 1
Synonyms: 2610014I16Rik, Prr24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66300
Homologene: 104918
Gm29394
Name: predicted gene 29394
Type: Gene
Species: Mouse
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 127,850,426 bp (GRCm38)
  • G to A, chromosome 1 at 133,388,476 bp (GRCm38)
  • T to A, chromosome 1 at 143,646,866 bp (GRCm38)
  • T to A, chromosome 1 at 184,074,446 bp (GRCm38)
  • T to A, chromosome 1 at 193,174,779 bp (GRCm38)
  • A to G, chromosome 2 at 31,354,730 bp (GRCm38)
  • G to A, chromosome 2 at 70,245,304 bp (GRCm38)
  • T to C, chromosome 2 at 103,455,088 bp (GRCm38)
  • T to C, chromosome 2 at 144,568,644 bp (GRCm38)
  • T to C, chromosome 3 at 36,947,941 bp (GRCm38)
  • G to T, chromosome 3 at 87,751,173 bp (GRCm38)
  • G to A, chromosome 3 at 88,104,350 bp (GRCm38)
  • T to A, chromosome 3 at 89,183,892 bp (GRCm38)
  • A to G, chromosome 3 at 109,934,908 bp (GRCm38)
  • T to C, chromosome 5 at 30,064,112 bp (GRCm38)
  • T to C, chromosome 5 at 70,782,465 bp (GRCm38)
  • C to T, chromosome 5 at 71,008,010 bp (GRCm38)
  • C to A, chromosome 5 at 87,843,135 bp (GRCm38)
  • T to A, chromosome 5 at 103,527,132 bp (GRCm38)
  • C to A, chromosome 5 at 121,286,781 bp (GRCm38)
  • G to C, chromosome 6 at 87,111,857 bp (GRCm38)
  • G to A, chromosome 7 at 16,273,134 bp (GRCm38)
  • T to C, chromosome 7 at 23,320,772 bp (GRCm38)
  • A to T, chromosome 7 at 28,360,285 bp (GRCm38)
  • T to A, chromosome 7 at 80,081,161 bp (GRCm38)
  • A to G, chromosome 7 at 100,882,802 bp (GRCm38)
  • A to G, chromosome 7 at 127,025,752 bp (GRCm38)
  • T to A, chromosome 8 at 40,826,707 bp (GRCm38)
  • A to T, chromosome 9 at 21,067,801 bp (GRCm38)
  • A to G, chromosome 9 at 38,219,572 bp (GRCm38)
  • G to T, chromosome 9 at 111,362,297 bp (GRCm38)
  • G to A, chromosome 9 at 119,486,773 bp (GRCm38)
  • A to G, chromosome 10 at 81,640,064 bp (GRCm38)
  • T to C, chromosome 10 at 86,713,185 bp (GRCm38)
  • T to C, chromosome 10 at 107,688,393 bp (GRCm38)
  • T to C, chromosome 11 at 34,228,607 bp (GRCm38)
  • T to C, chromosome 11 at 72,030,335 bp (GRCm38)
  • T to C, chromosome 11 at 78,165,427 bp (GRCm38)
  • T to A, chromosome 11 at 83,283,907 bp (GRCm38)
  • C to T, chromosome 11 at 84,380,513 bp (GRCm38)
  • T to A, chromosome 11 at 97,258,353 bp (GRCm38)
  • T to A, chromosome 11 at 102,016,680 bp (GRCm38)
  • A to G, chromosome 12 at 65,140,854 bp (GRCm38)
  • T to A, chromosome 13 at 9,654,647 bp (GRCm38)
  • G to A, chromosome 14 at 67,008,765 bp (GRCm38)
  • T to C, chromosome 14 at 79,419,224 bp (GRCm38)
  • A to G, chromosome 15 at 28,236,628 bp (GRCm38)
  • A to G, chromosome 15 at 58,069,326 bp (GRCm38)
  • A to G, chromosome 15 at 98,672,645 bp (GRCm38)
  • C to T, chromosome 16 at 18,544,164 bp (GRCm38)
  • C to A, chromosome 16 at 58,484,773 bp (GRCm38)
  • T to A, chromosome 17 at 23,359,210 bp (GRCm38)
  • C to T, chromosome 17 at 28,353,828 bp (GRCm38)
  • G to A, chromosome 17 at 71,394,833 bp (GRCm38)
  • A to C, chromosome 18 at 36,953,687 bp (GRCm38)
  • A to T, chromosome 18 at 73,739,018 bp (GRCm38)
  • T to A, chromosome 19 at 4,149,498 bp (GRCm38)
  • T to C, chromosome 19 at 21,826,089 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9593 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069386-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.