Strain Name:
C57BL/6J-MtgxR9704Btlr/Mmmh
Stock Number:
069497-MU
Citation ID:
RRID:MMRRC_069497-MU
Other Names:
R9704 (G1)
Major Collection:

Strain Information

Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Ulk2
Name: unc-51 like kinase 2
Synonyms: A830085I22Rik, Unc51.2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29869
Homologene: 5891
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Fgfr-1, Fr1, Hspy, FGFR-I, Eask, Flt-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Epc1
Name: enhancer of polycomb homolog 1
Synonyms: 2400007E14Rik, A930032N02Rik, 5730566F07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13831
Homologene: 32627
Luzp1
Name: leucine zipper protein 1
Synonyms: 2700072H04Rik, Luzp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269593
Homologene: 11545
Dclk2
Name: doublecortin-like kinase 2
Synonyms: 6330415M09Rik, Click-II, Dcamkl2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70762
Homologene: 69431
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Onecut1
Name: one cut domain, family member 1
Synonyms: Hnf6, Hfh12, Oc1, D9Ertd423e, OC-1, HNF6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15379
HGNC: HGNC:8138
Homologene: 3309
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74044
Homologene: 37826
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Tpsb2
Name: tryptase beta 2
Synonyms: MMCP-6, Mcp6, Mcp-6, Mcpt6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17229
VEGA: 17
Homologene: 55729
Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhs-f, MyHC-IIa, MHC2A, Myhsf1, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: brachyphalangy, Bph
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212326
Homologene: 27540
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243659
Homologene: 49545
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320492
Homologene: 14194
Hk3
Name: hexokinase 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212032
HGNC: HGNC:4925
Homologene: 55633
Pp2d1
Name: protein phosphatase 2C-like domain containing 1
Synonyms: 4921523A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110332
VEGA: 17
Homologene: 16981
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Meig1
Name: meiosis expressed gene 1
Synonyms: Meg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104362
Homologene: 56414
Gabrr2
Name: gamma-aminobutyric acid type A receptor subunit rho 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14409
HGNC: HGNC:4091
Homologene: 20471
Srd5a1
Name: steroid 5 alpha-reductase 1
Synonyms: 4930435F02Rik, Srd5a-1, 0610031P22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78925
Homologene: 37426
Nxph2
Name: neurexophilin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18232
HGNC: HGNC:8076
Homologene: 7454
Spag11b
Name: sperm associated antigen 11B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546038
Homologene: 83383
Ighv2-9
Name: immunoglobulin heavy variable 2-9
Synonyms: Gm16700
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 640046
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 11,518,689 bp (GRCm38)
  • G to A, chromosome 1 at 87,503,288 bp (GRCm38)
  • A to G, chromosome 2 at 3,409,299 bp (GRCm38)
  • T to C, chromosome 2 at 23,399,711 bp (GRCm38)
  • G to T, chromosome 2 at 27,005,225 bp (GRCm38)
  • C to T, chromosome 2 at 181,352,112 bp (GRCm38)
  • A to G, chromosome 3 at 86,920,080 bp (GRCm38)
  • T to C, chromosome 3 at 100,952,604 bp (GRCm38)
  • G to A, chromosome 4 at 33,063,305 bp (GRCm38)
  • G to A, chromosome 4 at 43,237,102 bp (GRCm38)
  • T to A, chromosome 4 at 136,541,293 bp (GRCm38)
  • C to A, chromosome 4 at 149,655,382 bp (GRCm38)
  • A to T, chromosome 5 at 74,620,218 bp (GRCm38)
  • A to T, chromosome 5 at 121,310,681 bp (GRCm38)
  • C to A, chromosome 6 at 23,120,888 bp (GRCm38)
  • CTCTTCATGATTTTCTT to CTCTT, chromosome 6 at 131,301,649 bp (GRCm38)
  • T to G, chromosome 7 at 75,147,672 bp (GRCm38)
  • A to G, chromosome 8 at 19,141,458 bp (GRCm38)
  • A to G, chromosome 8 at 25,573,563 bp (GRCm38)
  • G to A, chromosome 8 at 45,342,465 bp (GRCm38)
  • G to A, chromosome 9 at 74,862,976 bp (GRCm38)
  • A to G, chromosome 11 at 61,825,868 bp (GRCm38)
  • A to T, chromosome 11 at 67,180,791 bp (GRCm38)
  • A to C, chromosome 11 at 120,873,705 bp (GRCm38)
  • T to A, chromosome 12 at 113,879,126 bp (GRCm38)
  • T to C, chromosome 13 at 11,722,760 bp (GRCm38)
  • T to A, chromosome 13 at 15,723,473 bp (GRCm38)
  • G to T, chromosome 13 at 48,805,898 bp (GRCm38)
  • A to G, chromosome 13 at 55,012,440 bp (GRCm38)
  • T to A, chromosome 13 at 69,594,967 bp (GRCm38)
  • C to G, chromosome 15 at 28,247,819 bp (GRCm38)
  • A to G, chromosome 17 at 25,366,860 bp (GRCm38)
  • T to C, chromosome 17 at 53,515,879 bp (GRCm38)
  • T to C, chromosome 18 at 6,440,130 bp (GRCm38)
  • C to A, chromosome 19 at 29,298,330 bp (GRCm38)
  • T to C, chromosome 19 at 41,584,059 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9704 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069497-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.