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Strain Name:
C57BL/6J-MtgxR9743Btlr/Mmmh
Stock Number:
069989-MU
Citation ID:
RRID:MMRRC_069989-MU
Other Names:
R9743 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Mkks
Name: McKusick-Kaufman syndrome
Synonyms: 1300013E18Rik, Bbs6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59030
HGNC: HGNC:7108
Homologene: 10318
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, CSB, C130058G22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Taf4
Name: TATA-box binding protein associated factor 4
Synonyms: Taf2c1, TAFII135, TAFII130, Taf4a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228980
Homologene: 55723
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 87,934,128 bp (GRCm38)
  • G to A, chromosome 1 at 130,841,803 bp (GRCm38)
  • T to C, chromosome 1 at 143,647,109 bp (GRCm38)
  • T to C, chromosome 1 at 156,673,533 bp (GRCm38)
  • T to C, chromosome 2 at 26,996,800 bp (GRCm38)
  • G to A, chromosome 2 at 27,005,479 bp (GRCm38)
  • C to T, chromosome 2 at 27,974,493 bp (GRCm38)
  • A to G, chromosome 2 at 31,797,704 bp (GRCm38)
  • A to G, chromosome 2 at 87,107,496 bp (GRCm38)
  • T to C, chromosome 2 at 136,881,072 bp (GRCm38)
  • C to T, chromosome 2 at 179,939,799 bp (GRCm38)
  • A to T, chromosome 3 at 126,940,145 bp (GRCm38)
  • T to C, chromosome 4 at 88,676,693 bp (GRCm38)
  • A to T, chromosome 4 at 134,284,504 bp (GRCm38)
  • G to A, chromosome 4 at 155,860,799 bp (GRCm38)
  • T to C, chromosome 5 at 106,874,259 bp (GRCm38)
  • G to A, chromosome 6 at 42,911,901 bp (GRCm38)
  • A to G, chromosome 6 at 43,202,295 bp (GRCm38)
  • C to A, chromosome 6 at 101,377,717 bp (GRCm38)
  • A to T, chromosome 6 at 123,396,410 bp (GRCm38)
  • T to C, chromosome 7 at 10,170,679 bp (GRCm38)
  • C to A, chromosome 7 at 118,551,229 bp (GRCm38)
  • T to C, chromosome 8 at 28,719,773 bp (GRCm38)
  • T to G, chromosome 9 at 4,464,457 bp (GRCm38)
  • A to G, chromosome 9 at 20,212,544 bp (GRCm38)
  • T to C, chromosome 9 at 20,668,489 bp (GRCm38)
  • T to G, chromosome 10 at 41,922,602 bp (GRCm38)
  • T to C, chromosome 10 at 86,047,909 bp (GRCm38)
  • T to A, chromosome 10 at 107,685,121 bp (GRCm38)
  • A to T, chromosome 11 at 23,656,119 bp (GRCm38)
  • A to G, chromosome 11 at 53,951,749 bp (GRCm38)
  • A to G, chromosome 11 at 77,832,478 bp (GRCm38)
  • T to C, chromosome 11 at 83,648,602 bp (GRCm38)
  • T to C, chromosome 13 at 13,634,738 bp (GRCm38)
  • C to T, chromosome 13 at 24,872,316 bp (GRCm38)
  • A to G, chromosome 13 at 49,551,674 bp (GRCm38)
  • A to G, chromosome 14 at 20,363,343 bp (GRCm38)
  • T to G, chromosome 14 at 32,576,986 bp (GRCm38)
  • T to A, chromosome 14 at 51,049,913 bp (GRCm38)
  • T to C, chromosome 14 at 52,171,482 bp (GRCm38)
  • T to C, chromosome 14 at 59,413,553 bp (GRCm38)
  • G to A, chromosome 15 at 66,689,990 bp (GRCm38)
  • T to C, chromosome 16 at 32,780,824 bp (GRCm38)
  • T to A, chromosome 17 at 19,812,213 bp (GRCm38)
  • T to A, chromosome 17 at 21,723,357 bp (GRCm38)
  • T to C, chromosome 17 at 25,241,700 bp (GRCm38)
  • T to A, chromosome 17 at 47,469,315 bp (GRCm38)
  • T to C, chromosome 17 at 71,273,872 bp (GRCm38)
  • T to A, chromosome 17 at 79,710,379 bp (GRCm38)
  • A to C, chromosome 19 at 29,716,861 bp (GRCm38)
  • T to C, chromosome 19 at 44,942,133 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9743 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069989-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.