Strain Name:
C57BL/6J-MtgxR0552Btlr/Mmmh
Stock Number:
038744-MU
Citation ID:
RRID:MMRRC_038744-MU
Other Names:
R0552 (G1), C57BL/6J-MtgxR0552Btlr
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: AP-2(beta), E130018K07Rik, Tcfap2b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Nmu
Name: neuromedin U
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56183
HGNC: HGNC:7859
Homologene: 4863
Ssbp4
Name: single stranded DNA binding protein 4
Synonyms: Ssdp4, 1210002E11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76900
Homologene: 41881
Plekha1
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms: TAPP1, C920009D07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101476
Homologene: 11001
Hsd17b12
Name: hydroxysteroid (17-beta) dehydrogenase 12
Synonyms: 2610510O05Rik, KIK-I, keratoadhesin, keratonectin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56348
Homologene: 95094
Golga5
Name: golgin A5
Synonyms: Ret-II
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27277
VEGA: 12
HGNC: HGNC:4428
Homologene: 38009
Rufy3
Name: RUN and FYVE domain containing 3
Synonyms: 2810428M05Rik, Rpipx, D5Bwg0860e, 6330416M07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52822
Homologene: 87809
Tango6
Name: transport and golgi organization 6
Synonyms: Tmco7, Tango6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Txlna
Name: taxilin alpha
Synonyms: Txln, IL14, 2600010N21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109658
Homologene: 14062
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Slit2
Name: slit guidance ligand 2
Synonyms: Drad-1, E130320P19Rik, E030015M03Rik, Slil3, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Muc20
Name: mucin 20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224116
Homologene: 17135
Pbrm1
Name: polybromo 1
Synonyms: 2310032M22Rik, 2610016F04Rik, Pb1, BAF180
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Rasgef1b
Name: RasGEF domain family, member 1B
Synonyms: 4732452O09Rik, Gpig4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320292
Homologene: 14860
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Cola-2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Tns1
Name: tensin 1
Synonyms: Tns, E030018G17Rik, E030037J05Rik, 1110018I21Rik, 1200014E20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Mppe1
Name: metallophosphoesterase 1
Synonyms: Pgap5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225651
VEGA: 18
Homologene: 41512
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: Prss7, enterokinase, A130097D21Rik, enteropeptidase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Adam9
Name: ADAM metallopeptidase domain 9
Synonyms: Mltng, MDC9, MDC9, Mltng
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627111
Homologene: 115024
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: 5730435J12Rik, p96, D15Wsu122e, D630005B22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Kbtbd10
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Plxnc1
Name: plexin C1
Synonyms: 2510048K12Rik, CD232, vespr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Zfp563
Name: zinc finger protein 563
Synonyms: Zfp413, zinc finger protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240068
Homologene: 77346
C9
Name: complement component 9
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Ahcyl
Name: adenosylhomocysteinase like
Synonyms: Gm4737
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11615
VEGA: 16
HGNC: HGNC:343
Or5p58
Name: olfactory receptor family 5 subfamily P member 58
Synonyms: GA_x6K02T2PBJ9-10424354-10423383, Olfr482, MOR204-14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258728
Homologene: 133604
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, C030044P22Rik, Melk2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53791
Homologene: 20698
Try4
Name: trypsin 4
Synonyms: 0910001B19Rik, Td
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22074
Homologene: 106639
Klhdc8b
Name: kelch domain containing 8B
Synonyms: 4931406O17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78267
Homologene: 45463
Or10j2
Name: olfactory receptor family 10 subfamily J member 2
Synonyms: GA_x6K02T2R7CC-581296-580364, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-8, MOR267-12P
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258645
HGNC: HGNC:8175
Homologene: 8218
Phyh
Name: phytanoyl-CoA hydroxylase
Synonyms: Lnap1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16922
HGNC: HGNC:8940
Homologene: 4530
Lcn3
Name: lipocalin 3
Synonyms: Vnsp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16820
Homologene: 74958
Or4c10b
Name: olfactory receptor family 4 subfamily C member 10B
Synonyms: GA_x6K02T2Q125-51319458-51320387, Olfr1257, MOR232-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258984
Homologene: 115501
Arsj
Name: arylsulfatase J
Synonyms: 9330196J05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271970
Homologene: 35257
Akr1b10
Name: aldo-keto reductase family 1, member B10
Synonyms: 2310005E10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67861
Homologene: 128412
Spmip4
Name: sperm microtubule inner protein 4
Synonyms: 4921507P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70821
Homologene: 69433
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 19,234,225 bp
  • A to T, chromosome 1 at 73,920,563 bp
  • T to C, chromosome 1 at 173,270,805 bp
  • A to G, chromosome 1 at 182,975,696 bp
  • A to G, chromosome 2 at 4,936,101 bp
  • T to C, chromosome 2 at 25,766,409 bp
  • T to C, chromosome 2 at 52,148,756 bp
  • G to A, chromosome 2 at 69,670,210 bp
  • C to T, chromosome 2 at 89,880,891 bp
  • A to T, chromosome 2 at 94,043,935 bp
  • A to G, chromosome 3 at 126,439,344 bp
  • C to T, chromosome 3 at 144,916,775 bp
  • A to T, chromosome 4 at 129,629,191 bp
  • A to G, chromosome 5 at 16,328,043 bp
  • A to T, chromosome 5 at 48,238,379 bp
  • A to T, chromosome 5 at 76,344,107 bp
  • A to G, chromosome 5 at 88,584,270 bp
  • T to C, chromosome 5 at 99,221,350 bp
  • A to G, chromosome 6 at 4,516,960 bp
  • A to G, chromosome 6 at 34,392,985 bp
  • T to A, chromosome 6 at 41,302,337 bp
  • C to T, chromosome 6 at 50,584,528 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 6 at 142,345,737 bp
  • T to C, chromosome 7 at 44,613,681 bp
  • A to G, chromosome 7 at 81,317,347 bp
  • A to G, chromosome 7 at 108,094,778 bp
  • A to T, chromosome 7 at 127,392,332 bp
  • T to C, chromosome 7 at 130,882,399 bp
  • A to T, chromosome 8 at 24,963,010 bp
  • C to T, chromosome 8 at 54,693,096 bp
  • A to G, chromosome 8 at 70,599,859 bp
  • G to T, chromosome 8 at 106,747,279 bp
  • G to C, chromosome 9 at 108,449,223 bp
  • A to T, chromosome 10 at 94,833,701 bp
  • A to G, chromosome 11 at 30,145,985 bp
  • G to T, chromosome 12 at 55,676,765 bp
  • A to G, chromosome 12 at 75,931,004 bp
  • A to T, chromosome 12 at 102,484,493 bp
  • A to G, chromosome 12 at 112,612,574 bp
  • T to A, chromosome 14 at 31,035,959 bp
  • C to T, chromosome 15 at 6,435,414 bp
  • A to T, chromosome 15 at 6,445,437 bp
  • T to C, chromosome 15 at 44,489,546 bp
  • T to A, chromosome 15 at 99,229,456 bp
  • G to A, chromosome 16 at 32,793,930 bp
  • T to A, chromosome 16 at 46,154,592 bp
  • C to T, chromosome 16 at 79,024,749 bp
  • A to T, chromosome 17 at 18,168,964 bp
  • A to T, chromosome 17 at 33,104,685 bp
  • T to C, chromosome 18 at 61,871,560 bp
  • A to G, chromosome 18 at 67,237,348 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0552 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038744-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.