Strain Name:
C57BL/6J-MtgxR0684Btlr/Mmmh
Stock Number:
038869-MU
Citation ID:
RRID:MMRRC_038869-MU
Other Names:
R0684 (G1), C57BL/6J-MtgxR0684Btlr
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Pigf
Name: phosphatidylinositol glycan anchor biosynthesis, class F
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18701
HGNC: HGNC:8962
Homologene: 31103
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: 4933425K22Rik, Gtar, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214812
Homologene: 72220
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Copz1
Name: coatomer protein complex, subunit zeta 1
Synonyms: nonclathrin coat protein zeta1-COP, 5930435A22Rik, D4Ertd360e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56447
VEGA: 15
HGNC: HGNC:2243
Homologene: 9366
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 5830411K19Rik, 4933425I22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71148
Homologene: 136176
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228790
Homologene: 9098
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: 5033402L14Rik, SNAT2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67760
VEGA: 15
Homologene: 23132
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Wdr12
Name: WD repeat domain 12
Synonyms: Ytm1, Ytm1p, 4933402C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57750
Homologene: 10098
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60510
Homologene: 11062
Clock
Name: clock circadian regulator
Synonyms: 5330400M04Rik, KAT13D, bHLHe8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Tsr1
Name: TSR1 20S rRNA accumulation
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104662
Homologene: 5576
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233410
Homologene: 8759
Muc15
Name: mucin 15
Synonyms: D730046L02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269328
Homologene: 51680
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: TIF2/GRIP-1, Grip1, D1Ertd433e, glucocorticoid receptor-interacting protein 1, TIF2, TIF-2, SRC-2, KAT13C, bHLHe75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59090
Homologene: 32510
Rae1
Name: ribonucleic acid export 1
Synonyms: MNRP41, MNRP, 41, D2Ertd342e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66679
HGNC: HGNC:9828
Homologene: 2676
Efl1
Name: elongation factor like GTPase 1
Synonyms: 4932434J20Rik, 6030468D11Rik, D7Ertd791e, Eftud1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101592
Homologene: 11599
Bsph1
Name: binder of sperm protein homolog 1
Synonyms: LOC330470
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330470
Homologene: 86818
Pate14
Name: prostate and testis expressed 14
Synonyms: LOC235973, Sslp-1, A630095E13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235973
Emid1
Name: EMI domain containing 1
Synonyms: CO-5, Emu1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140703
Homologene: 135639
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218865
Homologene: 41261
Prpsap1
Name: phosphoribosyl pyrophosphate synthetase-associated protein 1
Synonyms: PAP39, 5730409F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67763
HGNC: HGNC:9466
Homologene: 55687
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Ertd410e, D19Wsu12e, b2b2633Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226090
Homologene: 121891
Ecsit
Name: ECSIT signalling integrator
Synonyms: Sitpec
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26940
Homologene: 8080
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: SemD, semaphorin III, sema III, collapsin-1, Semad
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, 2310010P21Rik, DXImx49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223809
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 84544
Homologene: 68489
Or2n1d
Name: olfactory receptor family 2 subfamily N member 1D
Synonyms: GA_x6K02T2PSCP-2779375-2780313, MOR256-7, Olfr136
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258803
Homologene: 119758
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: Ib, wl, agil
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: OAT-PG, BC026439
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210463
Homologene: 18166
Zfp955b
Name: zinc finger protein 955B
Synonyms: C430039G02Rik, A430003O12Rik, Gm4455
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043468
VEGA: 17
Homologene: 104925
Atxn1l
Name: ataxin 1-like
Synonyms: C330011L24Rik, ENSMUSG00000069895, Boat, D8Ertd587e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52335
Homologene: 19471
Or52n2b
Name: olfactory receptor family 52 subfamily N member 2B
Synonyms: GA_x6K02T2PBJ9-7546146-7545166, MOR34-2, MOR34-11, Olfr667
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259062
Homologene: 121559
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13097
Homologene: 117948
Or10a5
Name: olfactory receptor family 10 subfamily A member 5
Synonyms: GA_x6K02T2PBJ9-9415724-9416677, MOR263-1, P3, Olfr713
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259036
Homologene: 17470
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11498
Homologene: 86950
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: 2610209N15Rik, dehydrogenase/reductase (SDR family) member 13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208967
Homologene: 32609
Bdh2
Name: 3-hydroxybutyrate dehydrogenase, type 2
Synonyms: 1810026B04Rik, Dhrs6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69772
Homologene: 134268
Tgoln1
Name: trans-golgi network protein
Synonyms: TGN38A, TGN38, Ttgn1, D6Ertd384e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22134
Homologene: 137224
Zfp94
Name: zinc finger protein 94
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22756
Homologene: 86846
Bcl2l12
Name: BCL2 like 12
Synonyms: Bcl-L12, Bcl2-L12, 2810475P17Rik, 5430429M05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75736
Homologene: 12619
Adora2b
Name: adenosine A2b receptor
Synonyms: A2b, A2BR, AA2BR, A2b, Rs, A2BAR, ARA2B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11541
HGNC: HGNC:264
Homologene: 20167
Zfp3
Name: zinc finger protein 3
Synonyms: Fnp-1, Zfp-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193043
Homologene: 27406
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Syce3
Name: synaptonemal complex central element protein 3
Synonyms: 1700007E06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75459
Homologene: 85810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 13,224,651 bp
  • C to T, chromosome 1 at 60,089,366 bp
  • A to T, chromosome 1 at 71,595,809 bp
  • A to G, chromosome 2 at 21,211,666 bp
  • A to G, chromosome 2 at 110,733,815 bp
  • G to A, chromosome 2 at 153,397,522 bp
  • G to A, chromosome 2 at 173,005,164 bp
  • A to G, chromosome 3 at 135,291,013 bp
  • A to G, chromosome 4 at 103,139,434 bp
  • G to A, chromosome 5 at 13,556,527 bp
  • A to G, chromosome 5 at 76,245,518 bp
  • T to C, chromosome 5 at 90,263,998 bp
  • A to C, chromosome 6 at 72,615,991 bp
  • T to A, chromosome 7 at 13,473,063 bp
  • A to T, chromosome 7 at 24,303,070 bp
  • T to A, chromosome 7 at 44,996,601 bp
  • A to G, chromosome 7 at 46,783,469 bp
  • A to G, chromosome 7 at 81,037,875 bp
  • A to G, chromosome 7 at 82,651,886 bp
  • T to A, chromosome 7 at 104,916,634 bp
  • A to T, chromosome 7 at 107,036,682 bp
  • T to A, chromosome 7 at 107,425,136 bp
  • A to T, chromosome 8 at 109,732,384 bp
  • T to C, chromosome 9 at 22,076,500 bp
  • C to T, chromosome 9 at 36,637,880 bp
  • T to A, chromosome 9 at 65,731,201 bp
  • G to T, chromosome 10 at 28,483,298 bp
  • A to G, chromosome 10 at 80,156,502 bp
  • T to C, chromosome 11 at 5,143,866 bp
  • C to T, chromosome 11 at 62,249,169 bp
  • T to A, chromosome 11 at 70,771,569 bp
  • T to A, chromosome 11 at 74,907,941 bp
  • G to T, chromosome 11 at 78,036,963 bp
  • A to T, chromosome 11 at 116,471,491 bp
  • A to T, chromosome 12 at 81,419,654 bp
  • T to C, chromosome 13 at 64,089,068 bp
  • T to C, chromosome 14 at 21,668,781 bp
  • T to C, chromosome 14 at 30,031,613 bp
  • T to C, chromosome 14 at 60,023,144 bp
  • T to C, chromosome 15 at 57,263,362 bp
  • A to T, chromosome 15 at 82,617,550 bp
  • A to G, chromosome 15 at 89,390,445 bp
  • A to G, chromosome 15 at 91,841,467 bp
  • A to T, chromosome 15 at 96,695,287 bp
  • A to G, chromosome 15 at 103,296,531 bp
  • T to C, chromosome 16 at 46,117,790 bp
  • A to G, chromosome 17 at 33,302,973 bp
  • A to G, chromosome 17 at 38,335,844 bp
  • T to A, chromosome 17 at 73,943,891 bp
  • A to T, chromosome 17 at 87,020,495 bp
  • A to G, chromosome 19 at 29,632,541 bp
  • T to C, chromosome 19 at 39,391,056 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0684 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038869-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.