Strain Name:
C57BL/6J-MtgxR0959Btlr/Mmmh
Stock Number:
039088-MU
Citation ID:
RRID:MMRRC_039088-MU
Other Names:
R0959 (G1), C57BL/6J-MtgxR0959Btlr
Major Collection:

Strain Information

Slc26a5
Name: solute carrier family 26, member 5
Synonyms: prestin, Pres
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80979
HGNC: HGNC:9359
Homologene: 69472
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Mtg2
Name: mitochondrial ribosome associated GTPase 2
Synonyms: 2900056P18Rik, D2Bwg0647e, Gtpbp5, 1810011P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52856
Homologene: 9233
Scrib
Name: scribbled planar cell polarity
Synonyms: Crc, Scrb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Arl5b
Name: ADP-ribosylation factor-like 5B
Synonyms: 4930587A11Rik, Arl8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75869
Homologene: 101695
Med13l
Name: mediator complex subunit 13-like
Synonyms: 9030618F05Rik, Trap240L, Thrap2, 6330591G05Rik, 2210413I17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Epc1
Name: enhancer of polycomb homolog 1
Synonyms: 2400007E14Rik, A930032N02Rik, 5730566F07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13831
Homologene: 32627
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72103
Homologene: 49753
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: WSTF, Wbscr9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Nsrp1
Name: nuclear speckle regulatory protein 1
Synonyms: Ccdc55, NSpr70
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237859
Homologene: 134095
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: Nkcc1, mBSC2, sodium/potassium/chloride cotransporters, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000060893, ENSMUSG00000073653
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: p193, PH5P, Adprtl1, E230037B21Rik, C030027K23Rik, VPARP, VAULT3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Gfod1
Name: glucose-fructose oxidoreductase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328232
VEGA: 13
Homologene: 49581
Ccdc60
Name: coiled-coil domain containing 60
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269693
Homologene: 18624
Slc39a11
Name: solute carrier family 39 (metal ion transporter), member 11
Synonyms: 1810074D23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69806
Homologene: 12331
Thra
Name: thyroid hormone receptor alpha
Synonyms: Thra2, T3Ralpha, TR alpha 2, Thra1, Rvr, Erba, TR alpha 1, 6430529J03Rik, c-erbAalpha, Nr1a1, T3R[a]
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Riok1
Name: RIO kinase 1
Synonyms: 5430416A05Rik, 3110046C13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71340
VEGA: 13
Homologene: 6950
Dhx37
Name: DEAH-box helicase 37
Synonyms: LOC208144, LOC381671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208144
Homologene: 6641
Tmprss4
Name: transmembrane protease, serine 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214523
Homologene: 80930
Uncx
Name: UNC homeobox
Synonyms: Uncx4.1, Chx4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22255
Homologene: 56598
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Creb3
Name: cAMP responsive element binding protein 3
Synonyms: Luman, LZIP-2, LZIP-1, LZIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12913
HGNC: HGNC:2347
Homologene: 31375
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Gm7361
Name: predicted gene 7361
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 664837
Homologene: 69402
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Gbp5
Name: guanylate binding protein 5
Synonyms: 5330409J06Rik, Gbp5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229898
Homologene: 14183
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: Saps2, 1110033O10Rik, Pp6r2, B230107H12Rik, 8430411H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244234
Homologene: 133218
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040766
Homologene: 85300
4932441B19Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Izumo1
Name: izumo sperm-egg fusion 1
Synonyms: 1700058F15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73456
Homologene: 77701
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: ether a go-go related, LQT, ERG1, Lqt2, merg1b, M-erg, merg1a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Or2a56
Name: olfactory receptor family 2 subfamily A member 56
Synonyms: Olfr444, MOR261-2, GA_x6K02T2P3E9-4602571-4601639
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258650
Homologene: 88438
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17837
HGNC: HGNC:9750
Homologene: 136663
Rchy1
Name: ring finger and CHY zinc finger domain containing 1
Synonyms: Zfp363, 6720407C15Rik, PRO1996, Pirh2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68098
Homologene: 22894
Asap2
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms: LOC385250, Ddef2, 6530401G17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211914
HGNC: HGNC:2721
Homologene: 2888
Shc4
Name: SHC (Src homology 2 domain containing) family, member 4
Synonyms: 6230417E10Rik, 9930029B02Rik, LOC271849
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271849
Homologene: 19567
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: D430033C21Rik, MDC-L, Dtgn1, C130072N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Xkr4
Name: X-linked Kx blood group related 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 497097
Homologene: 45848
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: Gm447, LOC242997
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503884
Homologene: 65264
Timd5
Name: T cell immunoglobulin and mucin domain containing 5
Synonyms: Gm12169
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 210535
Homologene: 130033
Xylb
Name: xylulokinase homolog (H. influenzae)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102448
VEGA: 9
Homologene: 3746
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330502
Homologene: 51177
Rpusd4
Name: RNA pseudouridylate synthase domain containing 4
Synonyms: 2410001E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71989
Homologene: 32794
Mfsd9
Name: major facilitator superfamily domain containing 9
Synonyms: 4931419K03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211798
Homologene: 13100
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Zpbp2
Name: zona pellucida binding protein 2
Synonyms: 1700017D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69376
Homologene: 18892
Tada1
Name: transcriptional adaptor 1
Synonyms: Tada1l, 2900026B15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27878
Homologene: 41793
Ube2r2
Name: ubiquitin-conjugating enzyme E2R 2
Synonyms: 1200003M11Rik, Ubc3b, Cdc34b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67615
Homologene: 3210
Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms: Gwt1, 2610044A17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70325
Homologene: 6243
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 3,216,674 bp
  • G to T, chromosome 1 at 40,784,362 bp
  • A to T, chromosome 1 at 51,797,087 bp
  • A to T, chromosome 1 at 71,031,346 bp
  • GCCC to GC, chromosome 1 at 88,232,257 bp
  • A to G, chromosome 1 at 166,388,629 bp
  • T to A, chromosome 2 at 15,073,131 bp
  • T to C, chromosome 2 at 41,268,354 bp
  • T to A, chromosome 2 at 76,795,096 bp
  • C to T, chromosome 2 at 125,678,687 bp
  • T to G, chromosome 2 at 180,083,428 bp
  • C to T, chromosome 3 at 142,503,124 bp
  • A to G, chromosome 4 at 41,174,066 bp
  • T to C, chromosome 4 at 43,563,509 bp
  • A to G, chromosome 5 at 21,816,961 bp
  • A to C, chromosome 5 at 22,227,628 bp
  • C to T, chromosome 5 at 24,322,672 bp
  • A to T, chromosome 5 at 26,262,053 bp
  • A to T, chromosome 5 at 52,385,155 bp
  • A to G, chromosome 5 at 91,957,617 bp
  • A to G, chromosome 5 at 116,180,811 bp
  • A to T, chromosome 5 at 118,754,285 bp
  • T to G, chromosome 5 at 125,423,432 bp
  • T to G, chromosome 5 at 135,244,222 bp
  • A to T, chromosome 5 at 139,546,687 bp
  • T to A, chromosome 6 at 28,884,971 bp
  • G to T, chromosome 6 at 42,955,752 bp
  • T to A, chromosome 6 at 48,988,632 bp
  • G to A, chromosome 6 at 87,646,083 bp
  • C to T, chromosome 6 at 112,477,177 bp
  • G to A, chromosome 6 at 122,085,495 bp
  • A to G, chromosome 7 at 30,056,451 bp
  • A to G, chromosome 7 at 45,624,991 bp
  • A to G, chromosome 7 at 140,294,791 bp
  • A to G, chromosome 8 at 93,068,147 bp
  • T to A, chromosome 9 at 35,272,633 bp
  • T to C, chromosome 9 at 45,180,647 bp
  • T to C, chromosome 9 at 107,931,235 bp
  • C to A, chromosome 9 at 119,380,025 bp
  • C to G, chromosome 10 at 127,742,306 bp
  • C to A, chromosome 10 at 127,743,062 bp
  • A to T, chromosome 11 at 46,536,420 bp
  • G to A, chromosome 11 at 77,046,459 bp
  • G to A, chromosome 11 at 84,878,207 bp
  • G to A, chromosome 11 at 98,557,625 bp
  • A to G, chromosome 11 at 98,753,629 bp
  • G to T, chromosome 11 at 113,464,073 bp
  • A to G, chromosome 11 at 119,452,581 bp
  • T to C, chromosome 12 at 21,247,319 bp
  • G to A, chromosome 13 at 38,057,173 bp
  • A to T, chromosome 13 at 43,303,429 bp
  • C to T, chromosome 13 at 65,036,315 bp
  • G to A, chromosome 13 at 100,154,878 bp
  • T to A, chromosome 13 at 100,154,911 bp
  • T to C, chromosome 14 at 56,648,119 bp
  • G to A, chromosome 14 at 68,607,938 bp
  • A to T, chromosome 15 at 66,708,010 bp
  • G to C, chromosome 15 at 76,051,461 bp
  • G to A, chromosome 15 at 89,274,176 bp
  • A to G, chromosome 17 at 19,523,524 bp
  • T to C, chromosome 18 at 6,453,657 bp
  • T to A, chromosome 18 at 57,904,378 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0959 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039088-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.