Strain Name:
C57BL/6J-MtgxR1621Btlr/Mmmh
Stock Number:
039658-MU
Citation ID:
RRID:MMRRC_039658-MU
Other Names:
R1621 (G1), C57BL/6J-MtgxR1621Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Cd36
Name: CD36 molecule
Synonyms: Scarb3, FAT, fatty acid translocase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Psen2
Name: presenilin 2
Synonyms: Ad4h, ALG-3, PS-2, PS2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Fbxo36
Name: F-box protein 36
Synonyms: D1Ertd757e, 2410002G19Rik, 1110020F21Rik, 0610008D19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66153
Homologene: 11927
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: Mlk3, 2610017K16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Ets2
Name: E26 avian leukemia oncogene 2, 3' domain
Synonyms: Ets-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23872
HGNC: HGNC:3489
Homologene: 3838
G3bp2
Name: G3BP stress granule assembly factor 2
Synonyms: E430034L04Rik, G3BP2, G3BP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23881
Homologene: 137244
Nop14
Name: NOP14 nucleolar protein
Synonyms: Nol14, 2610033H07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75416
Homologene: 41773
Golga3
Name: golgin A3
Synonyms: 5430416E01Rik, G1-499-14, repro27, Mea-2, Mea2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Hs3st3a1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Synonyms: 3Ost3a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15478
HGNC: HGNC:5196
Homologene: 88735
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21975
Homologene: 3394
Cdc7
Name: cell division cycle 7
Synonyms: Cdc7, Cdc7l1, muCdc7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12545
HGNC: HGNC:1745
Homologene: 31166
Slc39a6
Name: solute carrier family 39 (metal ion transporter), member 6
Synonyms: Zip6, Ermelin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106957
Homologene: 8199
Chrm5
Name: cholinergic receptor, muscarinic 5
Synonyms: M5R, muscarinic acetylcholine receptor 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213788
HGNC: HGNC:1954
Homologene: 22697
Snx7
Name: sorting nexin 7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76561
Homologene: 22941
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Prl6a1
Name: prolactin family 6, subfamily a, member 1
Synonyms: PLP-B, Prlpb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19111
Homologene: 49261
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
A630091E08Rik
Name: RIKEN cDNA A630091E08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Slc25a48
Name: solute carrier family 25, member 48
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328258
Homologene: 27065
Lipn
Name: lipase, family member N
Synonyms: Lipl4, 2210418G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70166
Homologene: 66969
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, D12Bwg0831e, neurexin III alpha, 9330112C09Rik, neurexin III beta, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Ctns
Name: cystinosis, nephropathic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83429
HGNC: HGNC:2518
Homologene: 3625
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Actl6b
Name: actin-like 6B
Synonyms: Baf53b, Actl6, ArpNa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83766
HGNC: HGNC:160
Homologene: 81844
Palm3
Name: paralemmin 3
Synonyms: 4432412L15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74337
Homologene: 53493
Irgm2
Name: immunity-related GTPase family M member 2
Synonyms: Iigp2, Gtpi
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54396
Homologene: 78363
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Brdt
Name: bromodomain, testis-specific
Synonyms: Fsrg3, 7420412D09Rik, Brd6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114642
HGNC: HGNC:1105
Homologene: 21064
Or2z9
Name: olfactory receptor family 2 subfamily Z member 9
Synonyms: Olfr373, GA_x6K02T2NUPS-231686-232630, MOR282-2, MOR282-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258532
Homologene: 17287
Khdc1a
Name: KH domain containing 1A
Synonyms: Ndg1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 368204
Homologene: 134524
Pou2af1
Name: POU domain, class 2, associating factor 1
Synonyms: OBF-1, OBF.1, OCAB, BOB.1, OCA-B, Bob1, Bob-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18985
VEGA: 9
HGNC: HGNC:9211
Homologene: 4543
Arpc5l
Name: actin related protein 2/3 complex, subunit 5-like
Synonyms: 2010015J01Rik, ARC16-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74192
Homologene: 36463
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: OATP-E, Slc21a12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108115
Homologene: 9482
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 21,350,872 bp
  • T to A, chromosome 1 at 24,301,266 bp
  • T to A, chromosome 1 at 84,839,874 bp
  • A to T, chromosome 1 at 180,229,465 bp
  • T to C, chromosome 2 at 39,013,901 bp
  • G to T, chromosome 2 at 112,479,837 bp
  • A to T, chromosome 2 at 180,471,132 bp
  • T to C, chromosome 3 at 117,837,156 bp
  • T to A, chromosome 4 at 139,451,231 bp
  • C to T, chromosome 5 at 17,796,991 bp
  • A to T, chromosome 5 at 34,644,094 bp
  • A to G, chromosome 5 at 43,901,524 bp
  • G to A, chromosome 5 at 89,721,701 bp
  • A to T, chromosome 5 at 92,056,278 bp
  • A to G, chromosome 5 at 106,965,054 bp
  • T to A, chromosome 5 at 107,358,822 bp
  • G to A, chromosome 5 at 110,187,328 bp
  • A to G, chromosome 5 at 137,565,779 bp
  • T to C, chromosome 7 at 98,562,846 bp
  • A to G, chromosome 8 at 72,100,129 bp
  • G to A, chromosome 8 at 84,030,022 bp
  • A to G, chromosome 8 at 109,499,538 bp
  • C to T, chromosome 9 at 51,232,860 bp
  • A to G, chromosome 9 at 109,106,805 bp
  • A to G, chromosome 10 at 12,713,283 bp
  • A to G, chromosome 10 at 88,762,871 bp
  • T to C, chromosome 11 at 58,220,538 bp
  • A to T, chromosome 11 at 60,750,607 bp
  • G to T, chromosome 11 at 64,436,223 bp
  • A to G, chromosome 11 at 73,188,472 bp
  • A to G, chromosome 11 at 115,785,845 bp
  • T to C, chromosome 12 at 70,191,092 bp
  • A to G, chromosome 12 at 88,795,710 bp
  • C to T, chromosome 13 at 27,318,010 bp
  • T to C, chromosome 13 at 49,461,568 bp
  • T to A, chromosome 13 at 56,470,470 bp
  • A to G, chromosome 16 at 95,709,869 bp
  • G to A, chromosome 17 at 74,670,250 bp
  • T to C, chromosome 18 at 24,600,889 bp
  • T to A, chromosome 18 at 25,022,867 bp
  • A to G, chromosome 19 at 5,690,806 bp
  • A to G, chromosome 19 at 34,068,713 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1621 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039658-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.