Strain Name:
C57BL/6J-MtgxR2878Btlr/Mmmh
Stock Number:
040466-MU
Citation ID:
RRID:MMRRC_040466-MU
Other Names:
R2878 (G1), C57BL/6J-MtgxR2878Btlr
Major Collection:

Strain Information

Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms: GLT1, MGLT1, Eaat2, 1700091C19Rik, GLT-1, 2900019G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20511
Homologene: 3075
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Rbm6
Name: RNA binding motif protein 6
Synonyms: NY-LU-12, g16, Def-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19654
HGNC: HGNC:9903
Homologene: 31336
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72103
Homologene: 49753
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24128
Homologene: 6927
Palb2
Name: partner and localizer of BRCA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233826
Homologene: 11652
Camkmt
Name: calmodulin-lysine N-methyltransferase
Synonyms: 1700106N22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73582
VEGA: 17
Homologene: 11704
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, C030004M05Rik, 2410024A21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320806
Homologene: 6238
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C130057E09Rik, C030046E11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226089
Homologene: 13806
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98970
Homologene: 122246
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: NFAT4, NFATx, D8Ertd281e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Amph
Name: amphiphysin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Dync1li2
Name: dynein, cytoplasmic 1 light intermediate chain 2
Synonyms: LIC2, Dncli2, Dnclic2, Dlic2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234663
HGNC: HGNC:2966
Homologene: 4474
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52708
VEGA: 12
Homologene: 10918
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: LOC385628, 2210409B11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70144
Homologene: 13111
Dact2
Name: dishevelled-binding antagonist of beta-catenin 2
Synonyms: 2900084M21Rik, dapper2, Frd2, Dpr2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240025
VEGA: 17
Homologene: 18237
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: NMDAR1, NR1, Nmdar, M100174, GluRzeta1, Rgsc174
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Fussel18, Corl2, Gm7348
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: HZF-3, RNR-1, Nurr1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms: p52, NF kappaB2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18034
VEGA: 19
HGNC: HGNC:7795
Homologene: 1873
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Kcns1
Name: K+ voltage-gated channel, subfamily S, 1
Synonyms: Kv9.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16538
HGNC: HGNC:6300
Homologene: 20517
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Zcchc9
Name: zinc finger, CCHC domain containing 9
Synonyms: 1810019C21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69085
Homologene: 12999
Nebl
Name: nebulette
Synonyms: Lnebl, 1200007O21Rik, A630080F05Rik, D830029A09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74103
Homologene: 128431
Capn2
Name: calpain 2
Synonyms: m-calpain, Capa-2, Capa2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Vmn2r56
Name: vomeronasal 2, receptor 56
Synonyms: EG629079
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629079
Homologene: 104040
Cd53
Name: CD53 antigen
Synonyms: Ox-44, Tspan25
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12508
HGNC: HGNC:1686
Homologene: 20152
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208994
Homologene: 19478
Rem2
Name: rad and gem related GTP binding protein 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140743
Homologene: 11222
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Akr1c20
Name: aldo-keto reductase family 1, member C20
Synonyms: 2610528B18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 116852
Spopfm1
Name: speckle-type BTB/POZ protein family member 1
Synonyms: Gm4778
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212727
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Fbxw13
Name: F-box and WD-40 domain protein 13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211305
Homologene: 110776
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
Itpripl1
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 1
Synonyms: 1700041B20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73338
Homologene: 77641
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13086
Homologene: 85917
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235612
Homologene: 110776
Shcbp1l
Name: Shc SH2-domain binding protein 1-like
Synonyms: 1700012A16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71836
Homologene: 12800
Or5b106
Name: olfactory receptor family 5 subfamily B member 106
Synonyms: GA_x6K02T2RE5P-3473421-3472498, MOR202-17, Olfr1459
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258684
HGNC: HGNC:8324
Homologene: 115532
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Arhgap27
Name: Rho GTPase activating protein 27
Synonyms: 2310069I04Rik, 5730442P18Rik, Sh3d20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544817
Homologene: 45715
CAAA01083517.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Slc15a1
Name: solute carrier family 15 (oligopeptide transporter), member 1
Synonyms: PECT1, PEPT1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56643
VEGA: 14
Homologene: 38006
Naa80
Name: N(alpha)-acetyltransferase 80, NatH catalytic subunit
Synonyms: Nat6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56441
Homologene: 36325
Fbxo48
Name: F-box protein 48
Synonyms: A630050E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319701
Homologene: 18541
Gm17546
Name: predicted gene, 17546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102634389
VEGA: 15
Trem2
Name: triggering receptor expressed on myeloid cells 2
Synonyms: Trem2c, Trem2b, Trem2a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83433
Homologene: 10352
Wdr45
Name: WD repeat domain 45
Synonyms: Sfc19, C79260, JM5, DXImx38e, Wdrx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54636
Homologene: 48498
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,348,139 bp
  • TGTATTCCAGGCG to TG, chromosome 1 at 66,671,576 bp
  • T to A, chromosome 1 at 127,823,793 bp
  • T to C, chromosome 1 at 139,501,747 bp
  • A to T, chromosome 1 at 153,437,518 bp
  • T to A, chromosome 1 at 182,517,233 bp
  • A to G, chromosome 1 at 183,397,835 bp
  • C to A, chromosome 2 at 17,434,929 bp
  • A to G, chromosome 2 at 25,297,629 bp
  • G to A, chromosome 2 at 31,838,666 bp
  • A to G, chromosome 2 at 57,110,291 bp
  • G to A, chromosome 2 at 65,688,371 bp
  • T to C, chromosome 2 at 76,737,065 bp
  • A to T, chromosome 2 at 93,859,410 bp
  • T to A, chromosome 2 at 102,761,167 bp
  • A to G, chromosome 2 at 127,141,614 bp
  • C to A, chromosome 2 at 147,040,806 bp
  • A to G, chromosome 2 at 164,164,762 bp
  • G to T, chromosome 3 at 94,266,480 bp
  • T to C, chromosome 3 at 106,767,416 bp
  • G to A, chromosome 6 at 87,668,427 bp
  • T to G, chromosome 6 at 125,863,518 bp
  • A to C, chromosome 7 at 12,711,027 bp
  • G to A, chromosome 7 at 26,312,187 bp
  • A to G, chromosome 7 at 122,114,429 bp
  • A to G, chromosome 8 at 3,432,759 bp
  • A to C, chromosome 8 at 104,429,415 bp
  • C to A, chromosome 8 at 106,092,144 bp
  • A to G, chromosome 9 at 76,490,810 bp
  • A to T, chromosome 9 at 107,583,168 bp
  • T to C, chromosome 9 at 107,852,450 bp
  • A to G, chromosome 9 at 109,181,466 bp
  • A to T, chromosome 9 at 109,485,970 bp
  • T to C, chromosome 9 at 121,260,039 bp
  • C to T, chromosome 11 at 9,291,889 bp
  • A to G, chromosome 11 at 16,953,382 bp
  • T to C, chromosome 11 at 59,056,188 bp
  • A to G, chromosome 11 at 103,339,446 bp
  • A to T, chromosome 12 at 64,472,574 bp
  • A to C, chromosome 12 at 84,331,637 bp
  • A to T, chromosome 12 at 105,664,009 bp
  • G to A, chromosome 13 at 4,507,775 bp
  • G to A, chromosome 13 at 19,104,267 bp
  • A to T, chromosome 13 at 91,801,029 bp
  • A to G, chromosome 13 at 97,153,249 bp
  • A to G, chromosome 14 at 54,476,362 bp
  • A to G, chromosome 14 at 54,759,686 bp
  • T to A, chromosome 14 at 121,465,933 bp
  • A to T, chromosome 15 at 95,829,924 bp
  • G to T, chromosome 16 at 32,961,753 bp
  • A to G, chromosome 16 at 56,750,454 bp
  • T to C, chromosome 17 at 12,264,067 bp
  • A to T, chromosome 17 at 14,195,914 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to G, chromosome 17 at 48,351,113 bp
  • T to A, chromosome 17 at 83,410,174 bp
  • T to C, chromosome 17 at 85,431,551 bp
  • G to T, chromosome 18 at 76,860,724 bp
  • A to G, chromosome 19 at 13,146,407 bp
  • A to G, chromosome 19 at 29,602,330 bp
  • G to A, chromosome 19 at 46,307,441 bp
  • C to T, chromosome X at 7,727,372 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2878 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040466-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.