Strain Name:
C57BL/6J-MtgxR2915Btlr/Mmmh
Stock Number:
040502-MU
Citation ID:
RRID:MMRRC_040502-MU
Other Names:
R2915 (G1), C57BL/6J-MtgxR2915Btlr
Major Collection:

Strain Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: TRP1, TRP-1, Oca3, isa, Tyrp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Gdnf
Name: glial cell line derived neurotrophic factor
Synonyms: glial cell line-derived neurotrophic factor
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14573
VEGA: 15
HGNC: HGNC:4232
Homologene: 433
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Spred2
Name: sprouty-related EVH1 domain containing 2
Synonyms: Spred-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114716
Homologene: 24918
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109331
Homologene: 5571
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: 2810431N21Rik, PEPP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Sgk1
Name: serum/glucocorticoid regulated kinase 1
Synonyms: Sgk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20393
Homologene: 48364
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: Narg2, B230343B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93697
Homologene: 11618
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Dmkn
Name: dermokine
Synonyms: 1110014F24Rik, Dmkn, sk30, cI-36, dermokine, sk89
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73712
Homologene: 136295
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101568
Homologene: 9509
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Pax1
Name: paired box 1
Synonyms: wt, hbs, hunchback, wavy tail, Pax-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: 9430031J16Rik, Jr6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241134
Homologene: 18239
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140579
Homologene: 44338
Ssu2
Name: ssu-2 homolog
Synonyms: D630042P16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243612
Homologene: 136556
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: C030021G16Rik, Gabrb-2, C030002O17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
C330019G07Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Prss1
Name: serine protease 1 (trypsin 1)
Synonyms: PRSS1, Try-1, Try1, Trygn16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114228
Homologene: 88408
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76795
Homologene: 28106
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: LOC243645, LOC381812, Efcab4b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381812
Homologene: 41883
Or8g19
Name: olfactory receptor family 8 subfamily G member 19
Synonyms: MTPCR56, MOR171-6, GA_x6K02T2KYVW-1037-120, GA_x6K02T2PVTD-32841223-32842158, Olfr242, Olfr27
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258826
VEGA: 9
HGNC: HGNC:8484
Homologene: 110610
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Pcdhb12
Name: protocadherin beta 12
Synonyms: PcdhbL, Pcdh3, Pcdhb5F
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Otulin
Name: OTU deubiquitinase with linear linkage specificity
Synonyms: m7-1Sapc, gumby, m3Sapc, Fam105b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 432940
VEGA: 15
Homologene: 106591
Or5m8
Name: olfactory receptor family 5 subfamily M member 8
Synonyms: GA_x6K02T2Q125-47470765-47471775, Olfr1031, MOR200-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257916
Homologene: 73973
Vmn1r90
Name: vomeronasal 1 receptor 90
Synonyms: B430211C08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 627280
Homologene: 122945
Aif1
Name: allograft inflammatory factor 1
Synonyms: D17H6S50E, Iba1, G1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11629
HGNC: HGNC:352
Homologene: 1226
Otop2
Name: otopetrin 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237987
Homologene: 27803
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 252875
Homologene: 10371
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Or5t9
Name: olfactory receptor family 5 subfamily T member 9
Synonyms: Olfr1094, GA_x6K02T2Q125-48321457-48322449, MOR179-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258362
Homologene: 133609
Or4d6
Name: olfactory receptor family 4 subfamily D member 6
Synonyms: GA_x6K02T2RE5P-2468394-2467450, MOR239-5, Olfr1428
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258673
Homologene: 17339
Or4f14
Name: olfactory receptor family 4 subfamily F member 14
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15, Olfr1306
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258023
Homologene: 128383
B3gnt6
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Synonyms: Core3, Core-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272411
Homologene: 16339
Dusp13b
Name: dual specificity phosphatase 13B
Synonyms: LOC382853, Dusp13, TS-DSP6, LMW-DSP6, TMDP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27389
Homologene: 121602
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: NMDAR2D, GluRepsilon4, GluN2D, NR2D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Gprin2
Name: G protein regulated inducer of neurite outgrowth 2
Synonyms: C130040D06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 432839
VEGA: 14
Homologene: 40975
AC123686.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Six2
Name: sine oculis-related homeobox 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20472
Homologene: 56518
AC140409.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm20470
Name: predicted gene 20470
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,169,853 bp
  • C to G, chromosome 1 at 45,413,496 bp
  • C to T, chromosome 1 at 81,087,471 bp
  • A to G, chromosome 2 at 29,172,324 bp
  • T to A, chromosome 2 at 85,992,045 bp
  • T to C, chromosome 2 at 86,829,226 bp
  • G to T, chromosome 2 at 111,912,719 bp
  • A to G, chromosome 2 at 113,833,508 bp
  • A to G, chromosome 2 at 147,368,428 bp
  • A to G, chromosome 2 at 165,297,653 bp
  • A to G, chromosome 4 at 49,638,769 bp
  • A to G, chromosome 4 at 80,837,455 bp
  • A to T, chromosome 5 at 32,829,768 bp
  • T to C, chromosome 5 at 143,289,577 bp
  • C to T, chromosome 6 at 8,214,935 bp
  • A to T, chromosome 6 at 41,462,611 bp
  • T to C, chromosome 6 at 41,614,238 bp
  • A to T, chromosome 6 at 112,377,605 bp
  • A to G, chromosome 6 at 127,611,505 bp
  • A to G, chromosome 6 at 140,589,199 bp
  • T to C, chromosome 7 at 14,586,711 bp
  • A to G, chromosome 7 at 30,765,316 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • T to C, chromosome 7 at 45,833,357 bp
  • T to C, chromosome 7 at 98,193,593 bp
  • T to A, chromosome 7 at 118,210,879 bp
  • G to T, chromosome 9 at 39,144,466 bp
  • A to G, chromosome 9 at 40,670,787 bp
  • A to G, chromosome 9 at 69,410,840 bp
  • A to G, chromosome 10 at 7,760,934 bp
  • C to T, chromosome 10 at 21,996,601 bp
  • T to C, chromosome 11 at 19,998,215 bp
  • T to A, chromosome 11 at 42,591,907 bp
  • T to A, chromosome 11 at 50,149,736 bp
  • G to A, chromosome 11 at 72,910,326 bp
  • G to A, chromosome 11 at 115,329,146 bp
  • G to A, chromosome 12 at 112,040,461 bp
  • T to A, chromosome 14 at 21,740,137 bp
  • C to T, chromosome 14 at 34,195,081 bp
  • G to T, chromosome 14 at 55,064,557 bp
  • T to A, chromosome 15 at 7,815,649 bp
  • T to C, chromosome 15 at 10,486,642 bp
  • A to G, chromosome 15 at 27,619,630 bp
  • G to A, chromosome 17 at 35,172,151 bp
  • T to A, chromosome 17 at 56,104,389 bp
  • A to G, chromosome 17 at 85,685,188 bp
  • A to C, chromosome 18 at 7,926,131 bp
  • A to T, chromosome 18 at 37,437,640 bp
  • A to G, chromosome 18 at 70,522,700 bp
  • G to A, chromosome 19 at 12,108,625 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2915 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040502-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.