Strain Name:
C57BL/6J-MtgxR2919Btlr/Mmmh
Stock Number:
040504-MU
Citation ID:
RRID:MMRRC_040504-MU
Other Names:
R2919 (G1), C57BL/6J-MtgxR2919Btlr
Major Collection:

Strain Information

Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Sdf2
Name: stromal cell derived factor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20316
Homologene: 5045
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC386488, LOC333789, B3bp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333789
Homologene: 32396
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76501
Homologene: 8584
Cdc45
Name: cell division cycle 45
Synonyms: Cdc45l
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12544
HGNC: HGNC:1739
Homologene: 2616
Slc39a4
Name: solute carrier family 39 (zinc transporter), member 4
Synonyms: 1600025H15Rik, AWMS2, zip4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72027
VEGA: 15
Homologene: 15638
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, sam3, Fgfr-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Pfkp
Name: phosphofructokinase, platelet
Synonyms: 9330125N24Rik, PFK-C, 1200015H23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56421
HGNC: HGNC:8878
Homologene: 20579
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: 9630025B04Rik, MPP9, 4930548D04Rik, B930097C17Rik, MPP-9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Tmem107
Name: transmembrane protein 107
Synonyms: 1110004B13Rik, 2810049P21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66910
Homologene: 12052
Syk
Name: spleen tyrosine kinase
Synonyms: Sykb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20963
Homologene: 2390
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230119
Homologene: 8913
Mmrn2
Name: multimerin 2
Synonyms: EndoGlyx-1, Emilin3, ENDOGLYX1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Stradb
Name: STE20-related kinase adaptor beta
Synonyms: Als2cr2, D1Ucla2, PRO1038
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227154
Homologene: 10237
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Ccp4, EG244071, Nna1-l1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244071
Homologene: 17552
Slc13a5
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms: NaC2/NaCT, Nact, Indy, mINDY
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237831
Homologene: 21941
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Kif1a
Name: kinesin family member 1A
Synonyms: ATSV, N-3 kinesin, Kns1, LOC381283, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241514
Homologene: 18461
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Atg9b
Name: autophagy related 9B
Synonyms: Nos3as, LOC213948, Apg9l2, eONE
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213948
Homologene: 72638
Taar2
Name: trace amine-associated receptor 2
Synonyms: Gpr58
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209512
HGNC: HGNC:4514
Homologene: 110760
4921528O07Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Parp3
Name: poly (ADP-ribose) polymerase family, member 3
Synonyms: Adprt3, PARP-3, A930002C11Rik, Adprtl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235587
HGNC: HGNC:273
Homologene: 4005
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Tmem184c
Name: transmembrane protein 184C
Synonyms: 8430433H16Rik, Tmem34
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234463
Homologene: 32403
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Meak7
Name: MTOR associated protein, eak-7 homolog
Synonyms: 4632415K11Rik, Tldc1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74347
Homologene: 32494
Als2cl
Name: ALS2 C-terminal like
Synonyms: D930044G19Rik, mRn.49018
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235633
Homologene: 17152
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243659
Homologene: 49545
Or52b1
Name: olfactory receptor family 52 subfamily B member 1
Synonyms: Olfr690, MOR31-2, GA_x6K02T2PBJ9-7959171-7958224
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56860
Homologene: 10653
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: Tmbim1b, Lfg5, 4930511M11Rik, 4930500J03Rik, 4930403J02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75010
Homologene: 81927
Sult1d1
Name: sulfotransferase family 1D, member 1
Synonyms: tyrosine-ester sulfotransferase, 5033411P13Rik, Sultn
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53315
Homologene: 124464
Sgk2
Name: serum/glucocorticoid regulated kinase 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27219
Homologene: 8446
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Xin, Cmya1, mXin alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22238
Homologene: 137225
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: Kst1, 2010013B02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233836
Homologene: 14184
Edem2
Name: ER degradation enhancer, mannosidase alpha-like 2
Synonyms: 9530090G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108687
Homologene: 10075
Gm5884
Name: predicted pseudogene 5884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545878
Slc38a3
Name: solute carrier family 38, member 3
Synonyms: 0610012J02Rik, D9Ucla2, Snat3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76257
Homologene: 4983
Cd1d2
Name: CD1d2 antigen
Synonyms: CD1.2, Cd1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12480
HGNC: HGNC:1637
2310002L09Rik
Name: RIKEN cDNA 2310002L09 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71886
Homologene: 36448
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: uPFK-2, E330010H22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Pla2g4d
Name: phospholipase A2, group IVD
Synonyms: Pla2delta, 2610311B01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78390
Homologene: 52252
Slfnl1
Name: schlafen like 1
Synonyms: 4933406A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194219
Homologene: 44913
Hdac1-ps
Name: histone deacetylase 1, pseudogene
Synonyms: Gm10093, EG15181
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15181
VEGA: 17
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23801
Homologene: 8013
Oxgr1
Name: oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms: Gpr80, Cysltr3, LOC239283, P2Y15, Gpr99
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239283
VEGA: 14
HGNC: HGNC:4531
Homologene: 25878
Or5g23
Name: olfactory receptor family 5 subfamily G member 23
Synonyms: MOR175-9, Olfr1000, GA_x6K02T2Q125-47087719-47086775
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257899
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,992,669 bp
  • A to G, chromosome 1 at 93,046,742 bp
  • A to G, chromosome 1 at 130,189,850 bp
  • A to C, chromosome 1 at 163,056,772 bp
  • C to T, chromosome 2 at 11,484,327 bp
  • A to C, chromosome 2 at 41,770,899 bp
  • A to G, chromosome 2 at 82,235,816 bp
  • G to A, chromosome 2 at 85,608,410 bp
  • A to G, chromosome 2 at 91,490,730 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • T to C, chromosome 2 at 120,281,627 bp
  • T to C, chromosome 2 at 155,709,027 bp
  • T to G, chromosome 2 at 160,967,880 bp
  • T to G, chromosome 2 at 162,999,195 bp
  • C to A, chromosome 2 at 162,999,205 bp
  • C to G, chromosome 3 at 86,987,680 bp
  • A to G, chromosome 4 at 32,645,343 bp
  • T to C, chromosome 4 at 44,994,790 bp
  • A to T, chromosome 4 at 73,950,608 bp
  • G to T, chromosome 4 at 120,533,078 bp
  • G to A, chromosome 5 at 3,673,188 bp
  • T to A, chromosome 5 at 24,391,544 bp
  • A to G, chromosome 5 at 33,733,940 bp
  • G to A, chromosome 5 at 65,807,098 bp
  • A to G, chromosome 5 at 87,125,407 bp
  • A to G, chromosome 5 at 87,559,755 bp
  • G to A, chromosome 5 at 124,261,006 bp
  • A to G, chromosome 6 at 128,645,058 bp
  • T to A, chromosome 6 at 131,313,004 bp
  • G to A, chromosome 7 at 76,414,658 bp
  • C to T, chromosome 7 at 105,329,860 bp
  • GGTGC to G, chromosome 7 at 123,239,372 bp
  • A to T, chromosome 8 at 77,604,647 bp
  • C to A, chromosome 8 at 81,985,329 bp
  • G to A, chromosome 8 at 119,768,317 bp
  • C to T, chromosome 9 at 20,642,213 bp
  • T to A, chromosome 9 at 106,473,725 bp
  • A to T, chromosome 9 at 107,657,687 bp
  • A to T, chromosome 9 at 110,897,499 bp
  • T to C, chromosome 9 at 120,018,701 bp
  • T to A, chromosome 10 at 23,941,556 bp
  • T to C, chromosome 10 at 50,909,815 bp
  • T to C, chromosome 11 at 69,071,421 bp
  • C to T, chromosome 11 at 69,142,923 bp
  • T to C, chromosome 11 at 72,247,791 bp
  • C to T, chromosome 11 at 78,054,887 bp
  • G to C, chromosome 11 at 78,254,854 bp
  • T to C, chromosome 12 at 109,591,148 bp
  • C to T, chromosome 13 at 6,593,243 bp
  • C to T, chromosome 13 at 52,611,121 bp
  • T to C, chromosome 14 at 34,402,922 bp
  • T to A, chromosome 14 at 120,022,809 bp
  • A to G, chromosome 15 at 76,616,670 bp
  • A to G, chromosome 16 at 18,808,793 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to G, chromosome 17 at 78,492,846 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2919 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040504-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.