Strain Name:
C57BL/6J-MtgxR4638Btlr/Mmmh
Stock Number:
041900-MU
Citation ID:
RRID:MMRRC_041900-MU
Other Names:
R4638 (G1), C57BL/6J-MtgxR4638Btlr
Major Collection:

Strain Information

Park7
Name: Parkinson disease (autosomal recessive, early onset) 7
Synonyms: DJ-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57320
Homologene: 38295
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 171286
Homologene: 11628
Nek7
Name: NIMA (never in mitosis gene a)-related expressed kinase 7
Synonyms: 2810460C19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59125
Homologene: 69340
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215303
Homologene: 48706
Coro7
Name: coronin 7
Synonyms: 0610011B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78885
Homologene: 11573
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Abcg8
Name: ATP binding cassette subfamily G member 8
Synonyms: 1300003C16Rik, Sterolin-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67470
Homologene: 23361
Cebpa
Name: CCAAT/enhancer binding protein alpha
Synonyms: C/ebpalpha, Cebp, C/EBP alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12606
HGNC: HGNC:1833
Homologene: 3211
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: 1300019C06Rik, Narg1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66897
Homologene: 134838
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78912
Homologene: 2340
Sympk
Name: symplekin
Synonyms: 4632415H16Rik, 1500016F02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68188
Homologene: 37969
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: 2010309L07Rik, vp165, IRAP, 4732490P18Rik, gp160
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: PGAP1, 5033403E17Rik, D230012E17Rik, 9030223K07Rik, oto
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241062
Homologene: 41605
Tmem81
Name: transmembrane protein 81
Synonyms: 4930429O20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74626
Homologene: 12579
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: BC016201, Cngb1, Cngb1b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66661
Homologene: 38254
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: E330028L06Rik, DPD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, sy, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mouse
Chromosome: 2
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Wsu12e, b2b2633Clo, D19Ertd410e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226090
Homologene: 121891
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: TIE, D430008P04Rik, tie-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21846
Homologene: 3957
Pth1r
Name: parathyroid hormone 1 receptor
Synonyms: PTH1R, PPR, PTH/PTHrP receptor, PTH-related peptide receptor, Pthr1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19228
HGNC: HGNC:9608
Homologene: 267
Krba1
Name: KRAB-A domain containing 1
Synonyms: A930040G15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77827
Homologene: 15880
Kin
Name: Kin17 DNA and RNA binding protein
Synonyms: antigenic determinant of rec-A protein, Kin17
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16588
HGNC: HGNC:6327
Homologene: 8196
Or2ag17
Name: olfactory receptor family 2 subfamily AG member 17
Synonyms: MOR283-10P, GA_x6K02T2PBJ9-9168355-9167405, Olfr699
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258180
Homologene: 79391
Or12e7
Name: olfactory receptor family 12 subfamily E member 7
Synonyms: Olfr1126, MOR264-5, GA_x6K02T2Q125-48959068-48960012
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258834
Homologene: 133659
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Zfp773
Name: zinc finger protein 773
Synonyms: 2810409K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76373
Homologene: 137393
Slc7a10
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
Synonyms: Asc-1, D7Bwg0847e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53896
Homologene: 56767
Tmem198
Name: transmembrane protein 198
Synonyms: Tmem198-1, Tmem198a, A230078I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319998
Homologene: 44245
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp1, Lsh, Ity1, Ity, Nramp, host resistance locus Bcg/Ity/Lsh, Bcg, ity
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18173
Homologene: 73884
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
B4galt7
Name: beta-1,4-galactosyltransferase 7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218271
HGNC: HGNC:930
Homologene: 5248
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,525,412 bp
  • G to A, chromosome 1 at 74,375,278 bp
  • G to T, chromosome 1 at 75,479,707 bp
  • A to G, chromosome 1 at 132,508,205 bp
  • A to T, chromosome 1 at 138,544,300 bp
  • T to A, chromosome 1 at 193,356,359 bp
  • A to G, chromosome 2 at 10,090,359 bp
  • A to G, chromosome 2 at 26,365,302 bp
  • T to C, chromosome 2 at 65,099,237 bp
  • A to T, chromosome 2 at 76,822,477 bp
  • T to C, chromosome 2 at 87,457,983 bp
  • G to C, chromosome 2 at 98,664,007 bp
  • T to C, chromosome 2 at 180,190,413 bp
  • A to T, chromosome 3 at 119,266,077 bp
  • C to T, chromosome 4 at 118,483,842 bp
  • G to A, chromosome 4 at 150,907,099 bp
  • C to A, chromosome 5 at 14,680,433 bp
  • A to G, chromosome 5 at 76,990,295 bp
  • T to A, chromosome 6 at 48,409,751 bp
  • C to G, chromosome 6 at 142,354,741 bp
  • T to A, chromosome 7 at 7,135,336 bp
  • G to T, chromosome 7 at 19,043,460 bp
  • A to G, chromosome 7 at 35,120,262 bp
  • A to G, chromosome 7 at 35,197,930 bp
  • A to T, chromosome 7 at 106,790,998 bp
  • T to C, chromosome 7 at 118,195,926 bp
  • G to A, chromosome 8 at 95,266,019 bp
  • A to G, chromosome 9 at 110,727,073 bp
  • C to T, chromosome 10 at 88,954,697 bp
  • A to G, chromosome 11 at 96,957,474 bp
  • T to C, chromosome 13 at 13,696,794 bp
  • T to C, chromosome 13 at 55,600,146 bp
  • C to A, chromosome 14 at 79,340,033 bp
  • A to T, chromosome 16 at 4,632,287 bp
  • T to G, chromosome 16 at 33,590,323 bp
  • G to A, chromosome 17 at 17,575,307 bp
  • G to A, chromosome 17 at 24,506,628 bp
  • A to G, chromosome 17 at 84,691,941 bp
  • G to A, chromosome 18 at 37,817,278 bp
  • A to G, chromosome 18 at 58,010,304 bp
  • A to G, chromosome 19 at 29,639,959 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4638 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041900-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.