Strain Name:
C57BL/6J-MtgxR5080Btlr/Mmmh
Stock Number:
042669-MU
Citation ID:
RRID:MMRRC_042669-MU
Other Names:
R5080 (G1), C57BL/6J-MtgxR5080Btlr
Major Collection:

Strain Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Zbtb7c
Name: zinc finger and BTB domain containing 7C
Synonyms: Zbtb36, B230208J24Rik, Kr-pok
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 207259
VEGA: 18
Homologene: 17070
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Plcg2
Name: phospholipase C, gamma 2
Synonyms: PLCgamma2, Plcg-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Serpini1
Name: serine (or cysteine) peptidase inhibitor, clade I, member 1
Synonyms: Spi17, Neuroserpin, Ns, PI12
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20713
HGNC: HGNC:8943
Homologene: 21045
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70767
Homologene: 3447
Wdr37
Name: WD repeat domain 37
Synonyms: 3110035P10Rik, 4933417A01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 207615
Homologene: 40914
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74015
Homologene: 22869
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Strip2
Name: striatin interacting protein 2
Synonyms: Fam40b, Myoscape, D330017J20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320609
Homologene: 66198
Dpep2
Name: dipeptidase 2
Synonyms: F630103D06Rik, MBD-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319446
Homologene: 49703
Dcaf6
Name: DDB1 and CUL4 associated factor 6
Synonyms: NRIP, 1200006M05Rik, Iqwd1, PC326
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74106
Homologene: 10199
Wasf3
Name: WASP family, member 3
Synonyms: Wave3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245880
Homologene: 68527
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Acod1
Name: aconitate decarboxylase 1
Synonyms: Irg1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16365
Homologene: 35405
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: 1110062M20Rik, ORP-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Tns1
Name: tensin 1
Synonyms: Tns, E030018G17Rik, E030037J05Rik, 1110018I21Rik, 1200014E20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Zkscan4
Name: zinc finger with KRAB and SCAN domains 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544922
Homologene: 128718
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Ces1d
Name: carboxylesterase 1D
Synonyms: TGH, Ces3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104158
HGNC: HGNC:1863
Homologene: 35606
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Noxo1
Name: NADPH oxidase organizer 1
Synonyms: 2310034C04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71893
Homologene: 12418
Stard6
Name: StAR related lipid transfer domain containing 6
Synonyms: 4833424I06Rik, 1700011K09Rik, 4933429L05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170461
Homologene: 12578
Tmed3
Name: transmembrane p24 trafficking protein 3
Synonyms: 1200002G13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66111
Homologene: 7213
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: MOR172-1, GA_x6K02T2Q125-47777498-47778436, Olfr1052
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259012
Homologene: 79679
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5830484A20Rik, Ifi75, 5031415C07Rik, 52kDa, Ipr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: A430041B07Rik, Fam179b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Or2y1b
Name: olfactory receptor family 2 subfamily Y member 1B
Synonyms: Olfr10, MOR256-55, GA_x6K02T2QP88-6117098-6116163, L45
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18307
Homologene: 81347
Lce1e
Name: late cornified envelope 1E
Synonyms: 1110031B11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68694
Tomm34
Name: translocase of outer mitochondrial membrane 34
Synonyms: 2610100K07Rik, TOM34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67145
Homologene: 4956
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215928
Homologene: 129849
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: Fim2, CD115, Fms, Fim-2, M-CSFR, CSF-1R, Csfmr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Frg2f1
Name: FSHD region gene 2 family member 1
Synonyms: AA415398
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433752
Homologene: 86332
Rilpl2
Name: Rab interacting lysosomal protein-like 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80291
Homologene: 12723
Gm20939
Name: predicted gene, 20939
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100044193
VEGA: 17
Rpl15-ps6
Name: ribosomal protein L15, pseudogene 6
Synonyms: Gm10020
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100039748
VEGA: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 46,182,380 bp
  • C to A, chromosome 1 at 60,150,613 bp
  • G to T, chromosome 1 at 73,952,940 bp
  • G to T, chromosome 1 at 85,596,055 bp
  • T to C, chromosome 1 at 165,420,121 bp
  • T to C, chromosome 1 at 172,284,445 bp
  • T to A, chromosome 1 at 173,473,848 bp
  • T to C, chromosome 2 at 76,524,085 bp
  • G to A, chromosome 2 at 86,297,914 bp
  • T to A, chromosome 2 at 130,970,124 bp
  • G to A, chromosome 2 at 164,070,896 bp
  • A to T, chromosome 2 at 180,207,200 bp
  • T to C, chromosome 3 at 75,616,660 bp
  • C to T, chromosome 3 at 92,707,830 bp
  • T to A, chromosome 3 at 95,833,797 bp
  • T to C, chromosome 3 at 116,902,936 bp
  • T to C, chromosome 4 at 119,531,033 bp
  • T to C, chromosome 5 at 16,362,396 bp
  • T to A, chromosome 5 at 72,353,851 bp
  • T to A, chromosome 5 at 123,762,586 bp
  • T to C, chromosome 5 at 124,469,813 bp
  • C to T, chromosome 5 at 146,461,097 bp
  • T to A, chromosome 6 at 29,945,593 bp
  • T to A, chromosome 7 at 116,348,274 bp
  • G to A, chromosome 8 at 71,714,014 bp
  • T to C, chromosome 8 at 93,181,547 bp
  • G to A, chromosome 8 at 105,989,250 bp
  • A to G, chromosome 8 at 117,590,003 bp
  • G to T, chromosome 9 at 15,999,338 bp
  • G to A, chromosome 9 at 89,699,772 bp
  • G to A, chromosome 9 at 111,389,221 bp
  • T to A, chromosome 10 at 39,970,574 bp
  • G to T, chromosome 11 at 49,318,087 bp
  • T to C, chromosome 12 at 64,983,403 bp
  • T to C, chromosome 12 at 84,803,864 bp
  • C to T, chromosome 12 at 118,198,830 bp
  • A to T, chromosome 13 at 8,847,674 bp
  • A to G, chromosome 13 at 21,481,328 bp
  • A to T, chromosome 14 at 55,772,375 bp
  • A to G, chromosome 14 at 84,533,310 bp
  • G to A, chromosome 14 at 103,049,308 bp
  • C to A, chromosome 15 at 12,842,143 bp
  • A to G, chromosome 15 at 52,478,050 bp
  • T to A, chromosome 17 at 24,699,357 bp
  • T to C, chromosome 17 at 94,876,991 bp
  • T to C, chromosome 18 at 61,124,301 bp
  • A to T, chromosome 18 at 70,496,222 bp
  • A to C, chromosome 18 at 76,137,342 bp
  • A to T, chromosome 19 at 4,012,566 bp
  • T to A, chromosome 19 at 4,915,080 bp
  • A to T, chromosome 19 at 57,373,281 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042669-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.