Strain Name:
C57BL/6J-MtgxR5106Btlr/Mmmh
Stock Number:
042694-MU
Citation ID:
RRID:MMRRC_042694-MU
Other Names:
R5106 (G1), C57BL/6J-MtgxR5106Btlr
Major Collection:

Strain Information

Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
Synonyms: 2410004D02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71978
VEGA: 14
HGNC: HGNC:9304
Homologene: 2035
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPzeta, DSD-1-PG, phosphacan, RPTPz, Ptprz, Ptpz, Rptpbeta, PTPbeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Rgs7
Name: regulator of G protein signaling 7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 24012
Homologene: 2193
Ctcf
Name: CCCTC-binding factor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13018
Homologene: 4786
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Macroh2a1
Name: macroH2A.1 histone
Synonyms: MACROH2A1.2, H2afy, H2AF12M, mH2a1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Nudt5
Name: nudix hydrolase 5
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53893
HGNC: HGNC:8052
Homologene: 5388
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4b, 1300012C07Rik, Nedd4-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Trit1
Name: tRNA isopentenyltransferase 1
Synonyms: 2310075G14Rik, MOD5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66966
Homologene: 7010
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A330106J01Rik, A930009A08Rik, Gpr48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107515
Homologene: 10226
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68014
Homologene: 32381
Cenpf
Name: centromere protein F
Synonyms: mitosin, Lek1, 6530404A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Wrap53
Name: WD repeat containing, antisense to Trp53
Synonyms: Wdr79
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216853
Homologene: 9995
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3a, Stxbp3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20912
Homologene: 5260
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Slc39a2
Name: solute carrier family 39 (zinc transporter), member 2
Synonyms: F730005G13Rik, zip2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 214922
Homologene: 40957
Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Synonyms: Grl1, GR, Grl-1, glucocorticoid receptor
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14815
HGNC: HGNC:7978
Homologene: 30960
Smu1
Name: smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
Synonyms: SMU-1, 2600001O03Rik, 2610203K23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74255
Homologene: 10079
Map2k3
Name: mitogen-activated protein kinase kinase 3
Synonyms: MKK3, Prkmk3, MAP kinase kinase 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26397
HGNC: HGNC:6843
Homologene: 56430
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 3200002M13Rik, 1110028I06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70355
Homologene: 11099
C1qtnf2
Name: C1q and tumor necrosis factor related protein 2
Synonyms: CTRP2, 1810033K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69183
Homologene: 12899
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: 9430025M21Rik, C730009O10Rik, Lpd, lamellipodin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77300
Homologene: 71030
Gnl2
Name: guanine nucleotide binding protein nucleolar 2
Synonyms: Ngp-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230737
Homologene: 6858
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: 2310058B18Rik, 1810045E08Rik, MCCalpha, MCCA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Zfp791
Name: zinc finger protein 791
Synonyms: EG244556
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244556
Homologene: 27420
Or6c202
Name: olfactory receptor family 6 subfamily C member 202
Synonyms: Olfr771, MOR114-8, GA_x6K02T2PULF-10846420-10845467
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258540
Homologene: 74047
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Pcid2
Name: PCI domain containing 2
Synonyms: A730042J05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234069
Homologene: 10168
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: A430110N23Rik, s5d-srcrb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269855
Homologene: 77555
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Fdps
Name: farnesyl diphosphate synthetase
Synonyms: Fdpsl1, 6030492I17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110196
HGNC: HGNC:3631
Homologene: 1519
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102193
Homologene: 41193
Thoc5
Name: THO complex 5
Synonyms: 1700060C24Rik, Fmip, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Slc25a54
Name: solute carrier family 25, member 54
Synonyms: SCaMC-1like, 4930443G12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74686
Homologene: 82464
G6pd2
Name: glucose-6-phosphate dehydrogenase 2
Synonyms: Gpd2, G6pdx-ps1, Gpd-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14380
HGNC: HGNC:4057
Cope
Name: coatomer protein complex, subunit epsilon
Synonyms: 1110005D17Rik, Cope1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 59042
HGNC: HGNC:2234
Homologene: 5254
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: Nope, 9330155G14Rik, WI-16786, WI-18508
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Acd
Name: adrenocortical dysplasia
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 497652
Homologene: 23391
Or9k2b
Name: olfactory receptor family 9 subfamily K member 2B
Synonyms: GA_x6K02T2PULF-11851623-11850682, MOR210-2, Olfr826
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258671
Homologene: 121503
Gtf2a1l
Name: general transcription factor IIA, 1-like
Synonyms: Alf, 1700011N16Rik, Gtf2a1lf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71828
Homologene: 86732
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: Gm21505, A330103J02Rik, PSD93, Chapsyn-110, B330007M19Rik, B230218P12Rik, Dlgh2, LOC382816
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Gdap1
Name: ganglioside-induced differentiation-associated-protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14545
Homologene: 40713
Pomk
Name: protein-O-mannose kinase
Synonyms: 4930444A02Rik, Sgk196
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74653
Homologene: 12580
Rnf183
Name: ring finger protein 183
Synonyms: 5830442J12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76072
Homologene: 44917
Llcfc1
Name: LLLL and CFNLAS motif containing 1
Synonyms: 1700034O15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76606
Homologene: 81932
Cideb
Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
Synonyms: CIDE-B, DFFA-like B, 1110030C18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12684
HGNC: HGNC:1977
Homologene: 7666
Tmem221
Name: transmembrane protein 221
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434325
Homologene: 110174
Vmn2r38
Name: vomeronasal 2, receptor 38
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434110
Homologene: 113703
Gm6401
Name: predicted gene 6401
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 115486427
Rpl3l
Name: ribosomal protein L3-like
Synonyms: 1110057H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66211
Homologene: 68434
Or5d46
Name: olfactory receptor family 5 subfamily D member 46
Synonyms: Olfr1176, MOR174-5, GA_x6K02T2Q125-49824309-49825256
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258767
1700094J05Rik
Name: RIKEN cDNA 1700094J05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67523
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: Dnl1ll, G4.8, Dnase1ll, 2310005K03Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Or2ag20
Name: olfactory receptor family 2 subfamily AG member 20
Synonyms: GA_x6K02T2PBJ9-9247095-9248042, MOR283-12P, Olfr704
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257902
Homologene: 79345
Gm13734
Name: predicted gene 13734
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
A530083I20Rik
Name: RIKEN cDNA A530083I20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 17,146,953 bp
  • T to C, chromosome 1 at 60,533,300 bp
  • A to G, chromosome 1 at 175,076,850 bp
  • A to T, chromosome 1 at 189,683,808 bp
  • C to T, chromosome 2 at 5,854,829 bp
  • A to G, chromosome 2 at 87,135,999 bp
  • T to C, chromosome 2 at 88,340,110 bp
  • A to T, chromosome 2 at 109,997,595 bp
  • T to A, chromosome 3 at 35,972,564 bp
  • C to A, chromosome 3 at 89,099,403 bp
  • T to C, chromosome 3 at 108,794,927 bp
  • G to T, chromosome 3 at 109,112,864 bp
  • A to T, chromosome 4 at 40,743,104 bp
  • C to G, chromosome 4 at 62,428,228 bp
  • G to A, chromosome 4 at 116,099,764 bp
  • T to C, chromosome 4 at 123,054,313 bp
  • T to C, chromosome 4 at 125,053,536 bp
  • T to A, chromosome 4 at 147,584,155 bp
  • C to T, chromosome 5 at 61,810,352 bp
  • A to G, chromosome 6 at 23,000,028 bp
  • A to G, chromosome 6 at 41,685,376 bp
  • T to A, chromosome 7 at 4,936,665 bp
  • C to A, chromosome 7 at 9,075,170 bp
  • T to C, chromosome 7 at 92,442,686 bp
  • T to C, chromosome 7 at 96,843,149 bp
  • T to A, chromosome 7 at 106,865,388 bp
  • A to T, chromosome 8 at 13,079,648 bp
  • T to C, chromosome 8 at 25,986,376 bp
  • C to A, chromosome 8 at 70,310,447 bp
  • A to G, chromosome 8 at 71,555,878 bp
  • T to A, chromosome 8 at 85,110,630 bp
  • T to C, chromosome 8 at 105,681,498 bp
  • T to A, chromosome 8 at 105,694,006 bp
  • A to G, chromosome 8 at 120,088,009 bp
  • A to C, chromosome 9 at 64,153,584 bp
  • T to C, chromosome 9 at 65,124,701 bp
  • T to C, chromosome 9 at 122,896,133 bp
  • A to T, chromosome 10 at 76,401,444 bp
  • T to C, chromosome 10 at 129,160,237 bp
  • A to T, chromosome 10 at 130,180,308 bp
  • T to C, chromosome 11 at 4,910,630 bp
  • T to C, chromosome 11 at 35,612,367 bp
  • G to A, chromosome 11 at 43,486,053 bp
  • A to G, chromosome 11 at 60,941,882 bp
  • T to A, chromosome 11 at 69,562,462 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • A to G, chromosome 13 at 56,088,293 bp
  • A to G, chromosome 14 at 41,965,506 bp
  • A to G, chromosome 14 at 51,895,531 bp
  • T to C, chromosome 14 at 55,754,525 bp
  • A to T, chromosome 14 at 64,027,946 bp
  • T to C, chromosome 14 at 67,023,097 bp
  • G to T, chromosome 15 at 10,551,550 bp
  • T to C, chromosome 17 at 20,279,133 bp
  • T to A, chromosome 17 at 21,026,761 bp
  • A to G, chromosome 17 at 24,732,437 bp
  • T to C, chromosome 17 at 49,476,461 bp
  • A to G, chromosome 17 at 88,694,645 bp
  • A to C, chromosome 18 at 39,486,601 bp
  • C to T, chromosome 18 at 65,193,305 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5106 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042694-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.