Strain Name:
C57BL/6J-MtgxR5291Btlr/Mmmh
Stock Number:
042874-MU
Citation ID:
RRID:MMRRC_042874-MU
Other Names:
R5291 (G1), C57BL/6J-MtgxR5291Btlr
Major Collection:

Strain Information

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Prss12
Name: serine protease 12 neurotrypsin (motopsin)
Synonyms: motopsin, Bssp-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20116
Homologene: 133143
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, CNRasGEF, nRapGEP, RA-GEF-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Atp6v1e1
Name: ATPase, H+ transporting, lysosomal V1 subunit E1
Synonyms: lysosomal 31kDa, 2410029D23Rik, Atp6e2, H+ ATPase subunit E, D6Ertd385e, H(+)-ATPase E-like protein, Atp6v1e, E2, Atp6e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11973
HGNC: HGNC:857
Homologene: 1282
Terf1
Name: telomeric repeat binding factor 1
Synonyms: Trf1, Trbf1, Pin2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21749
Homologene: 7570
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: Bat2l2, 9630039I18Rik, 1810043M20Rik, Bat2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2900036C23Rik, 2810413I22Rik, 2410152H17Rik, 6030449K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Prmt3
Name: protein arginine N-methyltransferase 3
Synonyms: 2410018A17Rik, 2010005E20Rik, Hrmt1l3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71974
Homologene: 24255
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Rnf216
Name: ring finger protein 216
Synonyms: F830018F18Rik, UIP83, Ubce7ip1, 2810055G22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108086
Homologene: 19442
Tdrd3
Name: tudor domain containing 3
Synonyms: 4732418C03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219249
Homologene: 12771
Wdr26
Name: WD repeat domain 26
Synonyms: Gid7, 1600024A01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226757
Homologene: 11857
Fndc3b
Name: fibronectin type III domain containing 3B
Synonyms: 1600019O04Rik, fad104
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72007
Homologene: 11244
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: MNCb-2616, Sfrs4, SRp75, 5730499P16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57317
Homologene: 25624
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: TZK, ZAP-70, Srk
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)
Synonyms: IGnTC, 5330430K10Rik, IGnTA, IGnTB, IGnT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Cntrl
Name: centriolin
Synonyms: Cep110, b2b1468Clo, IB3/5, Ma2a8, 6720467O09Rik, Cep1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Pax3/7bp, 1810007M14Rik, Gcfc1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67367
Homologene: 9604
Herpud2
Name: HERPUD family member 2
Synonyms: 5031400M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80517
VEGA: 9
Homologene: 10756
Spats2
Name: spermatogenesis associated, serine-rich 2
Synonyms: Scr59, 59kDa, 2700012F11Rik, p59scr
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72572
VEGA: 15
Homologene: 11314
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Gata4
Name: GATA binding protein 4
Synonyms: Gata-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14463
HGNC: HGNC:4173
Homologene: 1551
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Lcn5
Name: lipocalin 5
Synonyms: MEP10, Erabp, mE-RABP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13863
Homologene: 7305
Slc35b2
Name: solute carrier family 35, member B2
Synonyms: 1110003M08Rik, PAPST1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73836
VEGA: 17
Homologene: 24504
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC, SREC-I
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380713
Homologene: 2741
Spag16
Name: sperm associated antigen 16
Synonyms: 4921511D23Rik, 4930585K05Rik, 4930524F24Rik, Pf20, Wdr29
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66722
Homologene: 11572
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Txlnb
Name: taxilin beta
Synonyms: 2310001N14Rik, Mdp77
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 378431
Homologene: 44534
Ptpre
Name: protein tyrosine phosphatase receptor type E
Synonyms: RPTPepsilon, PTPe, PTPepsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140577
Homologene: 8967
Or4c12
Name: olfactory receptor family 4 subfamily C member 12
Synonyms: Olfr1259, GA_x6K02T2Q125-51376062-51375133, MOR232-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258338
Homologene: 128115
Dlgap1
Name: DLG associated protein 1
Synonyms: 4933422O14Rik, GKAP/SAPAP, D17Bwg0511e, SAPAP1, DAP-1 beta, Gkap, Sapap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Ceacam1
Name: CEA cell adhesion molecule 1
Synonyms: MHVR1, Bgp1, Cea1, Hv2, C-CAM, Cea7, Cea-7, CD66a, Mhv-1, Cea-1, Bgp, Hv-2, mmCGM1, mCEA1, mmCGM2, Cc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26365
Homologene: 128630
Spred3
Name: sprouty-related EVH1 domain containing 3
Synonyms: Spred-3, D130060H24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101809
Homologene: 28061
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Or5k17
Name: olfactory receptor family 5 subfamily K member 17
Synonyms: GA_x54KRFPKG5P-55145984-55145034, MOR184-4, Olfr181
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259001
Homologene: 74112
Qsox2
Name: quiescin Q6 sulfhydryl oxidase 2
Synonyms: Qscn6l1, QSOX2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227638
Homologene: 65608
Cyp2j13
Name: cytochrome P450, family 2, subfamily j, polypeptide 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230459
HGNC: HGNC:2634
Homologene: 138297
Bend7
Name: BEN domain containing 7
Synonyms: E130319B15Rik, 1110017O21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209645
Homologene: 17660
Acot5
Name: acyl-CoA thioesterase 5
Synonyms: PTE-Ic
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217698
Homologene: 77351
Ugt1a7c
Name: UDP glucuronosyltransferase 1 family, polypeptide A7C
Synonyms: A10'
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394432
Homologene: 136043
F830104G03Rik
Name: RIKEN cDNA F830104G03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Or5d44
Name: olfactory receptor family 5 subfamily D member 44
Synonyms: Olfr1174-ps, GA_x6K02T2Q125-49796506-49795568, Olfr1174, MOR174-18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 546769
HGNC: HGNC:8336
Homologene: 77381
Gm26558
Name: predicted gene, 26558
Type: Gene
Species: Mouse
Chromosome: 2
Ighv1-73
Name: immunoglobulin heavy variable 1-73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668577
Gm10373
Name: predicted gene 10373
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100038728
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,819,086 bp
  • T to A, chromosome 1 at 36,771,962 bp
  • C to T, chromosome 1 at 69,870,348 bp
  • A to T, chromosome 1 at 88,095,509 bp
  • A to G, chromosome 1 at 93,295,724 bp
  • C to A, chromosome 1 at 162,705,582 bp
  • A to G, chromosome 1 at 181,187,696 bp
  • G to A, chromosome 2 at 4,763,241 bp
  • A to T, chromosome 2 at 25,661,098 bp
  • A to T, chromosome 2 at 26,217,698 bp
  • A to C, chromosome 2 at 35,134,060 bp
  • T to C, chromosome 2 at 40,903,003 bp
  • G to A, chromosome 2 at 70,661,529 bp
  • G to T, chromosome 2 at 88,310,836 bp
  • A to T, chromosome 2 at 89,943,436 bp
  • A to G, chromosome 2 at 181,352,095 bp
  • C to A, chromosome 3 at 27,642,995 bp
  • TTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTT to TTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTT, chromosome 3 at 56,890,413 bp
  • A to T, chromosome 3 at 79,070,059 bp
  • T to C, chromosome 3 at 123,505,463 bp
  • A to G, chromosome 4 at 32,823,446 bp
  • T to C, chromosome 4 at 96,068,329 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • T to A, chromosome 4 at 131,886,306 bp
  • T to C, chromosome 4 at 134,073,427 bp
  • C to A, chromosome 4 at 141,488,079 bp
  • G to T, chromosome 4 at 143,895,667 bp
  • A to G, chromosome 4 at 145,062,569 bp
  • A to G, chromosome 5 at 86,835,688 bp
  • A to G, chromosome 5 at 143,090,212 bp
  • T to A, chromosome 6 at 31,490,481 bp
  • T to A, chromosome 6 at 104,726,135 bp
  • C to A, chromosome 6 at 120,818,333 bp
  • T to A, chromosome 7 at 10,047,825 bp
  • T to A, chromosome 7 at 25,471,831 bp
  • T to A, chromosome 7 at 29,115,598 bp
  • T to A, chromosome 7 at 29,167,830 bp
  • T to A, chromosome 7 at 49,779,879 bp
  • G to A, chromosome 7 at 135,678,301 bp
  • T to G, chromosome 9 at 21,478,907 bp
  • T to C, chromosome 9 at 22,628,997 bp
  • C to T, chromosome 9 at 25,124,960 bp
  • A to G, chromosome 9 at 82,945,883 bp
  • A to T, chromosome 10 at 17,799,396 bp
  • G to A, chromosome 10 at 120,086,969 bp
  • A to G, chromosome 10 at 127,593,878 bp
  • T to C, chromosome 11 at 75,524,074 bp
  • T to G, chromosome 12 at 84,073,519 bp
  • A to G, chromosome 12 at 115,790,827 bp
  • A to G, chromosome 13 at 40,918,792 bp
  • A to C, chromosome 14 at 63,240,599 bp
  • A to T, chromosome 14 at 87,505,798 bp
  • A to G, chromosome 15 at 43,431,202 bp
  • T to A, chromosome 15 at 76,174,011 bp
  • G to T, chromosome 15 at 99,178,541 bp
  • T to A, chromosome 16 at 56,186,179 bp
  • T to C, chromosome 16 at 58,926,401 bp
  • C to T, chromosome 16 at 91,044,352 bp
  • T to C, chromosome 17 at 45,566,498 bp
  • A to G, chromosome 17 at 70,718,210 bp
  • A to G, chromosome 18 at 60,957,164 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5291 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042874-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.