Strain Name:
C57BL/6J-MtgxR5428Btlr/Mmmh
Stock Number:
042994-MU
Citation ID:
RRID:MMRRC_042994-MU
Other Names:
R5428 (G1), C57BL/6J-MtgxR5428Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, KHS, 4432415E19Rik, GCKR
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, rcw, Grm1, Gprc1a, nmf373, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Orc1
Name: origin recognition complex, subunit 1
Synonyms: Orc1l, MmORC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Foxp1
Name: forkhead box P1
Synonyms: 3110052D19Rik, 4932443N09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108655
HGNC: HGNC:3823
Homologene: 13092
Ylpm1
Name: YLP motif containing 1
Synonyms: Zap3, A930013E17Rik, ZAP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Abll, Arg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Nacc1
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: Btbd14b, 4930511N13Rik, Nac1, 2010001H03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66830
VEGA: 8
Homologene: 12042
Gtse1
Name: G two S phase expressed protein 1
Synonyms: Gtse-1, B99
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Skil
Name: SKI-like
Synonyms: SnoN, Skir, sno-dE3, SnoN2, 9130011J04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20482
Homologene: 3948
Fry
Name: FRY microtubule binding protein
Synonyms: 9330186A19Rik, cg003
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: Mypt1, 5730577I22Rik, D10Ertd625e, 1200015F06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Eif4h
Name: eukaryotic translation initiation factor 4H
Synonyms: Wscr1, E430026L18Rik, Wbscr1, D5Ertd355e, Eif4h
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22384
Homologene: 32536
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: BIG1, P200, ARFGEP1, D730028O18Rik, D130059B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: 1500017M13Rik, DNJ3, PRO3015, HIRIP4, 2010206B19Rik, mDj3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56445
Homologene: 21193
Ctnnd1
Name: catenin delta 1
Synonyms: Catns, Ctnnd, catenin (cadherin associated protein), delta 1, p120-catenin, P120
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Emc4
Name: ER membrane protein complex subunit 4
Synonyms: 2610318K02Rik, Tmem85
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68032
Homologene: 5879
Kctd17
Name: potassium channel tetramerisation domain containing 17
Synonyms: 2900008M13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72844
Homologene: 23468
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: EGF-TM7 receptor, 1110033N21Rik, Etl, Eltd1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Zfy1
Name: zinc finger protein 1, Y-linked
Synonyms: Zfy-1
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22767
Homologene: 56456
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana2, Mana-2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217351
Homologene: 23137
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270118
Homologene: 134147
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK, ASK1, Mekk5, 7420452D20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Colgalt1
Name: collagen beta(1-O)galactosyltransferase 1
Synonyms: Glt25d1, 2810024B22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234407
Homologene: 23465
Lrrc74b
Name: leucine rich repeat containing 74B
Synonyms: 4930451C15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74685
Homologene: 25894
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Sharpin
Name: SHANK-associated RH domain interacting protein
Synonyms: cpdm, SIPL1, 0610041B22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106025
Homologene: 11918
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Myt1l
Name: myelin transcription factor 1-like
Synonyms: Pmng1, C630034G21Rik, 2900093J19Rik, Png-1, 2900046C06Rik, Nztf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Vmn1r53
Name: vomeronasal 1 receptor 53
Synonyms: VN5, V1rb3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113853
Homologene: 113975
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, placenta-specific 3, PLAC3, PAPP-A2, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Sntb1
Name: syntrophin, basic 1
Synonyms: 59-1 DAP, beta1-Syntrophin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20649
Homologene: 9618
Gm6104
Name: predicted gene 6104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 619829
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: Wdr8, DD57, 5330425N03Rik, 2610044M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 59002
Homologene: 9857
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
Adra1d
Name: adrenergic receptor, alpha 1d
Synonyms: Adra-1, alpha1D-AR, Gpcr8, Adra1, Adra1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11550
HGNC: HGNC:280
Homologene: 551
Slc22a18
Name: solute carrier family 22 (organic cation transporter), member 18
Synonyms: Impt1, BWSCR1A, IMPT1, TSSC5, Slc22a1l, Orctl2, BWR1A, p45-BWR1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18400
Homologene: 1918
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382407
VEGA: 10
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: 2410012C07Rik, very-kind, VKIND, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: COX1, Cox-1, cyclooxygenase 1, Cox-3, Pghs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Arl14epl
Name: ADP-ribosylation factor-like 14 effector protein-like
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381142
VEGA: 18
Homologene: 85362
Ppp1r26
Name: protein phosphatase 1, regulatory subunit 26
Synonyms: LOC241289
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241289
Homologene: 49400
4921524L21Rik
Name: RIKEN cDNA 4921524L21 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70901
VEGA: 18
Homologene: 78009
Rap2a
Name: RAS related protein 2a
Synonyms: 5830461H18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76108
HGNC: HGNC:9861
Homologene: 10875
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Defa30
Name: defensin, alpha, 30
Synonyms: Gm15284
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100038927
Homologene: 113382
Tbc1d24
Name: TBC1 domain family, member 24
Synonyms: C530046L02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224617
Homologene: 27469
Aipl1
Name: aryl hydrocarbon receptor-interacting protein-like 1
Synonyms: A930007I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114230
HGNC: HGNC:359
Homologene: 22806
Tomm5
Name: translocase of outer mitochondrial membrane 5
Synonyms: 1110019J04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68512
Homologene: 104342
Gja10
Name: gap junction protein, alpha 10
Synonyms: Cx59, connexin-57, Cx-57, Cx57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14610
Homologene: 7733
Rcvrn
Name: recoverin
Synonyms: guanylate cyclase activator, S-modulin, cancer associated retinopathy protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19674
HGNC: HGNC:9937
Homologene: 2177
Gm27047
Name: predicted gene, 27047
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 102636949
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 4,880,345 bp
  • C to A, chromosome 1 at 10,160,835 bp
  • T to C, chromosome 1 at 156,642,111 bp
  • T to C, chromosome 1 at 158,814,785 bp
  • A to G, chromosome 2 at 28,450,626 bp
  • A to G, chromosome 2 at 36,245,268 bp
  • T to C, chromosome 2 at 76,761,104 bp
  • A to T, chromosome 2 at 76,885,136 bp
  • C to T, chromosome 2 at 84,616,789 bp
  • A to G, chromosome 2 at 112,367,355 bp
  • A to G, chromosome 2 at 131,561,403 bp
  • C to T, chromosome 2 at 146,334,494 bp
  • T to A, chromosome 3 at 31,097,498 bp
  • G to A, chromosome 3 at 151,542,686 bp
  • C to T, chromosome 4 at 3,905,538 bp
  • T to A, chromosome 4 at 32,601,169 bp
  • A to T, chromosome 4 at 45,106,689 bp
  • T to A, chromosome 4 at 108,599,940 bp
  • A to G, chromosome 4 at 123,384,868 bp
  • G to A, chromosome 4 at 154,145,274 bp
  • T to C, chromosome 5 at 134,625,379 bp
  • T to G, chromosome 5 at 150,405,359 bp
  • T to C, chromosome 6 at 90,223,413 bp
  • A to G, chromosome 6 at 99,016,631 bp
  • A to G, chromosome 6 at 130,630,564 bp
  • T to C, chromosome 7 at 83,612,547 bp
  • C to T, chromosome 7 at 128,704,524 bp
  • A to G, chromosome 7 at 139,908,962 bp
  • G to T, chromosome 7 at 143,479,345 bp
  • A to G, chromosome 8 at 21,135,403 bp
  • A to G, chromosome 8 at 70,784,733 bp
  • G to T, chromosome 8 at 71,622,776 bp
  • T to C, chromosome 8 at 84,676,154 bp
  • A to T, chromosome 8 at 85,540,175 bp
  • A to G, chromosome 9 at 13,705,895 bp
  • T to A, chromosome 10 at 10,719,563 bp
  • T to C, chromosome 10 at 12,693,431 bp
  • C to T, chromosome 10 at 20,023,653 bp
  • T to C, chromosome 10 at 41,464,788 bp
  • A to C, chromosome 10 at 83,574,522 bp
  • G to A, chromosome 10 at 99,445,147 bp
  • G to A, chromosome 10 at 108,253,347 bp
  • A to G, chromosome 11 at 67,700,049 bp
  • T to A, chromosome 11 at 72,030,487 bp
  • A to G, chromosome 11 at 117,700,762 bp
  • G to A, chromosome 12 at 29,832,332 bp
  • A to G, chromosome 12 at 57,689,834 bp
  • T to C, chromosome 12 at 69,838,013 bp
  • T to C, chromosome 12 at 85,030,229 bp
  • A to G, chromosome 14 at 98,169,269 bp
  • T to A, chromosome 14 at 120,478,994 bp
  • T to C, chromosome 15 at 8,330,296 bp
  • C to G, chromosome 15 at 55,642,795 bp
  • C to A, chromosome 15 at 76,350,666 bp
  • T to A, chromosome 15 at 78,428,782 bp
  • A to C, chromosome 15 at 85,862,139 bp
  • T to C, chromosome 16 at 17,558,261 bp
  • T to C, chromosome 16 at 90,991,518 bp
  • A to T, chromosome 17 at 24,181,772 bp
  • A to G, chromosome 17 at 64,712,300 bp
  • G to C, chromosome 18 at 6,635,918 bp
  • A to T, chromosome 18 at 46,926,320 bp
  • T to G, chromosome Y at 726,205 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5428 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042994-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.