Strain Name:
C57BL/6J-MtgxR5556Btlr/Mmmh
Stock Number:
043113-MU
Citation ID:
RRID:MMRRC_043113-MU
Other Names:
R5556 (G1), C57BL/6J-MtgxR5556Btlr
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: Acra-4, alpha4 nAChR, alpha4-nAChR, Acra4, a4 nicotinic receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, 6430591O13Rik, neurexin II alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: Cdc2l1, CDK11-p58, CDK11-p46, PITSLRE proteins, CDK11-p110, Cdc2l2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Adck2
Name: aarF domain containing kinase 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57869
Homologene: 49103
Aco2
Name: aconitase 2, mitochondrial
Synonyms: Irp1, Aco-2, Aco3, D10Wsu183e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11429
HGNC: HGNC:118
Homologene: 856
Prtg
Name: protogenin
Synonyms: Igdcc5, A230098A12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 4930429A22Rik, 8030493P09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208718
Homologene: 62417
Cast
Name: calpastatin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Xdh
Name: xanthine dehydrogenase
Synonyms: XO, Xox1, Xor, Xox-1, xanthine oxidase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Nsmaf
Name: neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms: factor associated with N-SMase activation, Fan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18201
HGNC: HGNC:8017
Homologene: 2652
Ska2
Name: spindle and kinetochore associated complex subunit 2
Synonyms: 1110001A07Rik, Fam33a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66140
Homologene: 11926
Panx1
Name: pannexin 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 55991
HGNC: HGNC:8599
Homologene: 49416
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Cd164l2
Name: CD164 sialomucin-like 2
Synonyms: 2310047N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69655
Homologene: 19231
Zfp334
Name: zinc finger protein 334
Synonyms: D2Ertd535e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228876
Homologene: 23076
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234076
Homologene: 32376
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: wmfl, Flk-2, Flk2, Flt-3, CD135
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Evi-1, Jbo, ZNFPR1B1, D630039M04Rik, Prdm3, Mds1, Evi1, MDS1-EVI1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Zfpl1
Name: zinc finger like protein 1
Synonyms: 1500015B20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 81909
Homologene: 4935
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Dnai7
Name: dynein axonemal intermediate chain 7
Synonyms: A230084G12Rik, Casc1, Las1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320662
Homologene: 41242
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Klhl42
Name: kelch-like 42
Synonyms: Klhdc5, C230080I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232539
Homologene: 45842
Or2j3
Name: olfactory receptor family 2 subfamily J member 3
Synonyms: MOR256-18, Olfr137, GA_x6K02T2PSCP-2749525-2748587
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258481
Homologene: 128084
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Dennd4b
Name: DENN domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229541
Homologene: 28281
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235441
Homologene: 4766
Disp3
Name: dispatched RND transporter family member 3
Synonyms: Ptchd2, G630052C06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242748
Homologene: 25712
Cst7
Name: cystatin F (leukocystatin)
Synonyms: Leukocystatin, cystatin-like metastasis-associated protein, CMAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13011
HGNC: HGNC:2479
Homologene: 37832
Ptprr
Name: protein tyrosine phosphatase receptor type R
Synonyms: PTPBR7, RPTPRR, PTP-SL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Tspan10
Name: tetraspanin 10
Synonyms: Ocsp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208634
Homologene: 49972
Cherp
Name: calcium homeostasis endoplasmic reticulum protein
Synonyms: DAN16, SCAF6, 5730408I11Rik, D8Wsu96e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 27967
Homologene: 4656
Decr1
Name: 2,4-dienoyl CoA reductase 1, mitochondrial
Synonyms: Decr, Nadph, 1200012F07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67460
HGNC: HGNC:2753
Homologene: 68178
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 5730518J08Rik, 2810429B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66646
Homologene: 12005
Fibp
Name: fibroblast growth factor (acidic) intracellular binding protein
Synonyms: 2010005N21Rik, 2010004G08Rik, 3010027N18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58249
VEGA: 19
HGNC: HGNC:3705
Homologene: 3106
Pcdhb6
Name: protocadherin beta 6
Synonyms: PcdhbF, Pcdhb5B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93877
HGNC: HGNC:8690
Homologene: 62177
Entrep2
Name: endosomal transmembrane epsin interactor 2
Synonyms: 5730507A09Rik, Fam189a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70638
Homologene: 77705
Or9r7
Name: olfactory receptor family 9 subfamily R member 7
Synonyms: MOR210-3, GA_x6K02T2PULF-11797746-11796799, Olfr824
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258669
Homologene: 45026
Sh3d21
Name: SH3 domain containing 21
Synonyms: 1700029G01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66938
Homologene: 12057
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228536
Homologene: 8976
Gm4204
Name: predicted gene 4204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100043064
Cndp2
Name: CNDP dipeptidase 2
Synonyms: Dip-2, Pep1, 0610010E05Rik, Cn2, Pep-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66054
VEGA: 18
Homologene: 10085
Mepe
Name: matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms: OF45
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94111
Homologene: 10623
Rbpjl
Name: recombination signal binding protein for immunoglobulin kappa J region-like
Synonyms: RBP-L, RBP-J kappa-like, Rbpsuhl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19668
Homologene: 7512
Gm15931
Name: predicted gene 15931
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 112136069
Trgc4
Name: T cell receptor gamma, constant 4
Synonyms: Tcrg-C4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107576
Ear-ps2
Name: eosinophil-associated, ribonuclease A family, pseudogene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93743
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 66,706,466 bp
  • T to C, chromosome 1 at 86,973,404 bp
  • C to A, chromosome 1 at 105,693,167 bp
  • G to A, chromosome 1 at 127,834,547 bp
  • T to C, chromosome 1 at 135,233,195 bp
  • T to C, chromosome 2 at 66,324,797 bp
  • T to A, chromosome 2 at 118,916,270 bp
  • A to T, chromosome 2 at 150,570,568 bp
  • A to G, chromosome 2 at 164,408,062 bp
  • T to C, chromosome 2 at 165,380,584 bp
  • A to G, chromosome 2 at 181,033,980 bp
  • A to G, chromosome 3 at 30,238,100 bp
  • G to A, chromosome 3 at 90,268,368 bp
  • C to T, chromosome 4 at 6,398,621 bp
  • C to T, chromosome 4 at 15,919,244 bp
  • T to C, chromosome 4 at 98,944,735 bp
  • T to C, chromosome 4 at 126,162,236 bp
  • T to A, chromosome 4 at 133,223,705 bp
  • C to T, chromosome 4 at 148,258,157 bp
  • C to T, chromosome 4 at 155,634,147 bp
  • G to A, chromosome 5 at 104,338,212 bp
  • T to A, chromosome 5 at 147,332,997 bp
  • T to G, chromosome 6 at 17,534,176 bp
  • T to C, chromosome 6 at 39,583,935 bp
  • T to A, chromosome 6 at 112,739,078 bp
  • T to A, chromosome 6 at 113,147,502 bp
  • C to A, chromosome 6 at 145,175,280 bp
  • C to A, chromosome 6 at 147,108,112 bp
  • A to T, chromosome 7 at 4,274,204 bp
  • A to G, chromosome 7 at 44,344,315 bp
  • A to G, chromosome 7 at 64,856,209 bp
  • G to A, chromosome 7 at 116,164,149 bp
  • T to A, chromosome 7 at 130,674,606 bp
  • G to A, chromosome 8 at 13,294,870 bp
  • C to G, chromosome 8 at 72,467,980 bp
  • G to A, chromosome 8 at 95,108,459 bp
  • T to C, chromosome 8 at 104,967,442 bp
  • A to G, chromosome 9 at 15,007,633 bp
  • G to A, chromosome 9 at 66,544,021 bp
  • T to C, chromosome 9 at 72,851,704 bp
  • A to G, chromosome 10 at 116,251,149 bp
  • A to T, chromosome 10 at 130,126,859 bp
  • A to T, chromosome 11 at 9,258,546 bp
  • T to A, chromosome 11 at 72,175,200 bp
  • A to G, chromosome 11 at 86,327,838 bp
  • G to T, chromosome 11 at 87,121,993 bp
  • A to T, chromosome 11 at 120,444,715 bp
  • T to G, chromosome 12 at 38,127,364 bp
  • A to T, chromosome 12 at 85,268,493 bp
  • A to T, chromosome 13 at 19,352,307 bp
  • A to G, chromosome 13 at 74,695,889 bp
  • G to A, chromosome 14 at 44,047,060 bp
  • T to C, chromosome 15 at 81,889,319 bp
  • T to A, chromosome 17 at 38,305,073 bp
  • T to C, chromosome 17 at 71,752,425 bp
  • G to T, chromosome 17 at 73,897,764 bp
  • T to A, chromosome 18 at 37,334,389 bp
  • A to G, chromosome 18 at 84,672,124 bp
  • T to A, chromosome 19 at 5,464,199 bp
  • C to T, chromosome 19 at 6,082,442 bp
  • C to A, chromosome 19 at 6,490,091 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5556 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043113-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.