Strain Name:
C57BL/6J-MtgxR5759Btlr/Mmmh
Stock Number:
043361-MU
Citation ID:
RRID:MMRRC_043361-MU
Other Names:
R5759 (G1)
Major Collection:

Strain Information

Slc35a1
Name: solute carrier family 35 (CMP-sialic acid transporter), member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24060
Homologene: 38181
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, Mcmd, P1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Exoc6
Name: exocyst complex component 6
Synonyms: hbd, Sec15, Sec15l1, 4833405E05Rik, msec15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Mmp20
Name: matrix metallopeptidase 20 (enamelysin)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30800
VEGA: 9
HGNC: HGNC:7167
Homologene: 21001
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: AF529169, DD1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209743
Homologene: 17782
Mfsd5
Name: major facilitator superfamily domain containing 5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106073
VEGA: 15
Homologene: 69517
Septin9
Name: septin 9
Synonyms: Sept9, PNUTL4, MSF1, Sint1, Msf, SL3-3 integration site 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Tcf25
Name: transcription factor 25 (basic helix-loop-helix)
Synonyms: 1100001J13Rik, 1810041K11Rik, D8Ertd325e, Nulp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66855
Homologene: 5701
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Ndfip2
Name: Nedd4 family interacting protein 2
Synonyms: 0710001O20Rik, 9130207N19Rik, N4wbp5a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76273
Homologene: 12636
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: Myst3, 9930021N24Rik, Zfp220, MOZ
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235048
Homologene: 138456
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Emp2
Name: epithelial membrane protein 2
Synonyms: Xmp
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13731
HGNC: HGNC:3334
Homologene: 1089
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Or8b1c
Name: olfactory receptor family 8 subfamily B member 1C
Synonyms: GA_x6K02T2PVTD-32165709-32166641, Olfr905, MOR167-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71096
Homologene: 56834
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102634333
Homologene: 131709
Trim34b
Name: tripartite motif-containing 34B
Synonyms: Gm15134, Trim34-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434218
Homologene: 128238
Ifi30
Name: interferon gamma inducible protein 30
Synonyms: IP30, lysosomal thio reductase IP30 precursor, GILT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65972
VEGA: 8
HGNC: HGNC:5398
Homologene: 38171
Or7e175
Name: olfactory receptor family 7 subfamily E member 175
Synonyms: Olfr869, MOR145-6, GA_x6K02T2PVTD-13878275-13879204
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258550
HGNC: HGNC:8396
Homologene: 138312
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: Glu5R, mGluR5, Gprc1e, 6430542K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Phf19
Name: PHD finger protein 19
Synonyms: 3321402G02Rik, 3110009G19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74016
Homologene: 12524
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: METH-1, ADAM-TS1, METH1, ADAMTS-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Or7e170
Name: olfactory receptor family 7 subfamily E member 170
Synonyms: GA_x6K02T2PVTD-13624132-13623212, Olfr862, MOR146-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258555
Homologene: 115540
Mybphl
Name: myosin binding protein H-like
Synonyms: 1110037P11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68753
Homologene: 19221
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: Mitsugumin 56, Mg56, 1110011D13Rik, Gup1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: Pyk1, Ack, ACK1, activated p21cdc42Hs kinase, P21cdc42Hs kinase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 51789
Homologene: 4224
Ing2
Name: inhibitor of growth family, member 2
Synonyms: Ing1l, P33ING2, ING2, 2810011M06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69260
HGNC: HGNC:6063
Homologene: 20388
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71325
Homologene: 84625
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545136
VEGA: 15
Homologene: 69502
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Tmem106b
Name: transmembrane protein 106B
Synonyms: 2310036D22Rik, 5830455K21Rik, 6430519M21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71900
Homologene: 56806
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Zfp1010
Name: zinc finger protein 1010
Synonyms: Gm14409
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 115489547
Arf2
Name: ADP-ribosylation factor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11841
Homologene: 56086
Trib1
Name: tribbles pseudokinase 1
Synonyms: Trb1, A530090O15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211770
Homologene: 75216
Trib3
Name: tribbles pseudokinase 3
Synonyms: Ifld2, Trb3, Nipk, SKIP3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228775
Homologene: 10902
BC100451
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 8,414,270 bp
  • CT to CTT, chromosome 1 at 20,808,748 bp
  • A to G, chromosome 1 at 46,277,120 bp
  • G to A, chromosome 1 at 46,615,367 bp
  • T to G, chromosome 2 at 34,897,123 bp
  • T to C, chromosome 2 at 91,162,075 bp
  • A to T, chromosome 2 at 152,343,295 bp
  • C to T, chromosome 2 at 160,983,762 bp
  • A to T, chromosome 2 at 177,264,972 bp
  • C to G, chromosome 3 at 93,471,556 bp
  • T to C, chromosome 3 at 108,374,754 bp
  • T to C, chromosome 3 at 138,068,658 bp
  • C to A, chromosome 4 at 34,675,032 bp
  • T to C, chromosome 5 at 96,709,916 bp
  • A to G, chromosome 6 at 13,075,042 bp
  • A to G, chromosome 7 at 10,047,978 bp
  • A to C, chromosome 7 at 88,026,600 bp
  • T to C, chromosome 7 at 104,331,433 bp
  • T to A, chromosome 7 at 105,764,176 bp
  • T to G, chromosome 8 at 22,938,012 bp
  • G to T, chromosome 8 at 47,669,005 bp
  • A to G, chromosome 8 at 70,766,544 bp
  • C to A, chromosome 8 at 111,890,210 bp
  • A to G, chromosome 8 at 122,507,655 bp
  • A to G, chromosome 8 at 123,381,457 bp
  • T to A, chromosome 9 at 7,628,377 bp
  • A to G, chromosome 9 at 19,884,188 bp
  • T to A, chromosome 9 at 20,137,932 bp
  • T to C, chromosome 9 at 22,249,661 bp
  • T to A, chromosome 9 at 38,473,535 bp
  • T to C, chromosome 9 at 54,375,508 bp
  • A to T, chromosome 9 at 89,601,072 bp
  • A to G, chromosome 9 at 95,874,402 bp
  • A to G, chromosome 9 at 121,788,277 bp
  • G to T, chromosome 9 at 122,853,146 bp
  • G to A, chromosome 11 at 103,983,633 bp
  • A to G, chromosome 11 at 117,352,268 bp
  • T to C, chromosome 11 at 118,333,646 bp
  • T to A, chromosome 14 at 105,302,316 bp
  • G to A, chromosome 15 at 59,654,501 bp
  • T to G, chromosome 15 at 99,279,717 bp
  • G to A, chromosome 15 at 102,281,078 bp
  • T to A, chromosome 16 at 10,284,510 bp
  • C to T, chromosome 16 at 32,680,664 bp
  • A to G, chromosome 16 at 85,798,048 bp
  • T to C, chromosome 18 at 34,497,435 bp
  • C to T, chromosome 19 at 37,573,741 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5759 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043361-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.