Strain Name:
C57BL/6J-MtgxR6208Btlr/Mmmh
Stock Number:
044342-MU
Citation ID:
RRID:MMRRC_044342-MU
Other Names:
R6208 (G1)
Major Collection:

Strain Information

Npc2
Name: NPC intracellular cholesterol transporter 2
Synonyms: HE1, 2700012J19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67963
VEGA: 12
Homologene: 4697
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Pou5f1
Name: POU domain, class 5, transcription factor 1
Synonyms: Oct4, Oct3/4, Oct-3/4, Otf4, Otf3, Oct-3, Otf3g, Otf3-rs7, Otf-4, Otf-3, Oct-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18999
Homologene: 8422
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, 2610511G22Rik, 6030460N08Rik, TRIP230, GMAP-210
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Snupn
Name: snurportin 1
Synonyms: 0610031A09Rik, Rnut1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66069
Homologene: 4166
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, Vam6, mVam6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269338
Homologene: 41025
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Rpusd1
Name: RNA pseudouridylate synthase domain containing 1
Synonyms: 2310051D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106707
VEGA: 17
Homologene: 12424
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Npnt
Name: nephronectin
Synonyms: POEM, 1110009H02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: vzg-1, LPA1, Kdt2, Gpcr26, Edg2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14745
HGNC: HGNC:3166
Homologene: 1072
Pard6a
Name: par-6 family cell polarity regulator alpha
Synonyms: Par6c, PAR6alpha, TAX40, Tip-40, 0710008C04Rik, 2610010A15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56513
Homologene: 9661
Rnd2
Name: Rho family GTPase 2
Synonyms: Arhn, Rohn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Cux2
Name: cut-like homeobox 2
Synonyms: Cux-2, Cux2, ENSMUSG00000072641, Cutl2, 1700051K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Hp1bp3
Name: heterochromatin protein 1, binding protein 3
Synonyms: Hp1bp74
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15441
Homologene: 7774
Tcea3
Name: transcription elongation factor A (SII), 3
Synonyms: S-II, SII-K1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21401
Homologene: 20684
Actl6a
Name: actin-like 6A
Synonyms: Actl6, Baf53a, 2810432C06Rik, ARP4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56456
Homologene: 55811
Srpra
Name: signal recognition particle receptor alpha
Synonyms: 1300011P19Rik, D11Mgi27, Srpr
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67398
Homologene: 2364
Xxylt1
Name: xyloside xylosyltransferase 1
Synonyms: AI480653
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268880
Homologene: 17610
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: 145kDa, SF3b150, SF3b145, SAP145, SF3b1, B230398H18Rik, 2810441F20Rik, 2610311M13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Phf21b
Name: PHD finger protein 21B
Synonyms: A730032D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271305
Homologene: 78154
Asap3
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms: UPLC1, 9430088F20Rik, Ddefl1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230837
Homologene: 41190
Scn2b
Name: sodium channel, voltage-gated, type II, beta
Synonyms: LOC214238, 2810451E09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72821
VEGA: 9
Homologene: 3373
Psmd5
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Synonyms: 1500032A03Rik, S5b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66998
HGNC: HGNC:9563
Homologene: 37999
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ttc38
Name: tetratricopeptide repeat domain 38
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239570
Homologene: 41208
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Vmn1r193
Name: vomeronasal 1 receptor 193
Synonyms: V1ri9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171259
Homologene: 110880
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77352
Homologene: 52328
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 328505
Homologene: 106613
Tead2
Name: TEA domain family member 2
Synonyms: TEF-4, TEAD-2, Etdf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21677
Homologene: 19662
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269209
Homologene: 49432
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3alpha, nesprin-3, nesprin-3beta, 4831426I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, D5Kng1, Gm1040
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433864
Homologene: 39776
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Optc
Name: opticin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Bsg
Name: basigin
Synonyms: neurothelin, CD147, 5A11/Basigin, EMMPRIN, HT-7, gp 42
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12215
HGNC: HGNC:1116
Homologene: 1308
Apol11a
Name: apolipoprotein L 11a
Synonyms: EG626615
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626615
VEGA: 15
HGNC: HGNC:618
Homologene: 129975
Slc43a1
Name: solute carrier family 43, member 1
Synonyms: PB39, 2610016F07Rik, Pov1, Lat3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72401
HGNC: HGNC:9225
Homologene: 2688
Lrrc61
Name: leucine rich repeat containing 61
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243371
Homologene: 41538
Thap7
Name: THAP domain containing 7
Synonyms: 1810004B07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69009
Homologene: 12293
Sprr2h
Name: small proline-rich protein 2H
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20762
Lce1d
Name: late cornified envelope 1D
Synonyms: 2310037L11Rik, Sprrl7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69611
Defa25
Name: defensin, alpha, 25
Synonyms: Defcr25
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13236
Homologene: 113382
Pcdhga4
Name: protocadherin gamma subfamily A, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93712
HGNC: HGNC:8702
Homologene: 81866
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d1a, Fam75d3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Gm20830
Name: predicted gene, 20830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 108168638
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,431,590 bp
  • A to T, chromosome 1 at 74,611,432 bp
  • T to C, chromosome 1 at 133,904,999 bp
  • C to T, chromosome 1 at 156,392,856 bp
  • T to A, chromosome 1 at 173,857,422 bp
  • A to T, chromosome 2 at 34,867,011 bp
  • A to G, chromosome 2 at 59,924,806 bp
  • A to G, chromosome 2 at 84,856,840 bp
  • A to T, chromosome 2 at 120,333,416 bp
  • A to T, chromosome 3 at 32,711,894 bp
  • T to C, chromosome 3 at 92,386,909 bp
  • G to A, chromosome 3 at 92,686,005 bp
  • A to G, chromosome 3 at 132,950,013 bp
  • G to A, chromosome 4 at 58,504,630 bp
  • A to G, chromosome 4 at 111,984,876 bp
  • A to G, chromosome 4 at 136,241,197 bp
  • A to T, chromosome 4 at 136,248,049 bp
  • A to G, chromosome 4 at 138,217,170 bp
  • G to T, chromosome 4 at 139,354,271 bp
  • A to T, chromosome 5 at 29,449,619 bp
  • G to A, chromosome 5 at 121,860,822 bp
  • C to T, chromosome 6 at 48,568,905 bp
  • G to T, chromosome 6 at 119,446,512 bp
  • A to G, chromosome 6 at 142,357,456 bp
  • G to T, chromosome 7 at 45,218,102 bp
  • A to G, chromosome 7 at 49,564,103 bp
  • A to G, chromosome 8 at 21,085,181 bp
  • T to C, chromosome 8 at 45,027,613 bp
  • T to C, chromosome 8 at 105,702,234 bp
  • A to G, chromosome 9 at 35,215,995 bp
  • A to G, chromosome 9 at 45,118,030 bp
  • A to T, chromosome 9 at 48,393,378 bp
  • T to A, chromosome 9 at 56,982,963 bp
  • A to G, chromosome 9 at 70,376,605 bp
  • A to T, chromosome 10 at 10,719,946 bp
  • A to G, chromosome 10 at 34,394,586 bp
  • T to A, chromosome 10 at 76,615,057 bp
  • T to C, chromosome 10 at 79,708,838 bp
  • G to A, chromosome 11 at 59,067,648 bp
  • G to T, chromosome 11 at 78,023,591 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • C to A, chromosome 11 at 119,281,171 bp
  • G to T, chromosome 12 at 84,757,145 bp
  • T to A, chromosome 12 at 101,898,895 bp
  • A to G, chromosome 12 at 104,943,363 bp
  • T to C, chromosome 13 at 11,895,220 bp
  • T to A, chromosome 13 at 22,218,968 bp
  • C to A, chromosome 13 at 59,700,564 bp
  • T to C, chromosome 14 at 9,573,435 bp
  • T to G, chromosome 14 at 103,295,228 bp
  • C to T, chromosome 15 at 77,517,041 bp
  • T to A, chromosome 15 at 84,795,116 bp
  • T to A, chromosome 15 at 85,841,497 bp
  • T to C, chromosome 16 at 17,528,436 bp
  • A to G, chromosome 16 at 31,007,808 bp
  • T to C, chromosome 17 at 20,268,329 bp
  • A to T, chromosome 17 at 25,730,378 bp
  • T to C, chromosome 17 at 35,510,460 bp
  • T to A, chromosome 18 at 37,686,709 bp
  • A to T, chromosome 19 at 5,275,098 bp
  • T to G, chromosome Y at 6,916,792 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6208 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044342-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.